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Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis.
Altern Ther Health Med 2010 Mar-Apr; 16(2):32-40AT

Abstract

OBJECTIVE

To review efficacy studies of antioxidant and antiinflammatory dietary supplements used to manage osteoarthritis (OA) and rheumatoid arthritis (RA) and make conclusions about their place in therapy. Glucosamine, chondroitin, and methyl sulfonyl methane were excluded.

DATA SOURCES

A literature search was conducted using MEDLINE (1996 through January 2009), EMBASE, Cochrane Library, Natural Medicines Comprehensive Database, and Natural Standard, with bibliographic review of relevant articles. Cited studies from before our search range were included if they represented the only published human data available. Search words included "antioxidant," "antiinflammatory," "cat's claw," "ginger," "fish oil," "omega-3," "turmeric," "vitamin E," "vitamin C," "Baikal skullcap," "barberry," "Chinese goldthread," "green tea," "Indian holy basil," "hu zhang,""oregano," and"rosemary."

STUDY SELECTION AND DATA EXTRACTION

Efficacy studies published in English were included provided they evaluated the dietary supplements in patients with OA or RA.

DATA SYNTHESIS

Our search strategy yielded 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study) in addition to one meta-analysis and one review article.

CONCLUSIONS

Three studies support cat's claw alone or in combination for OA, and two studies support omega-3 fatty acids for the treatment of RA. We cannot recommend use of vitamin E alone; vitamins A, C, and E in combination; ginger; turmeric; or Zyflamend (New Chapter, Brattleboro, Vermont) for the treatment of OA or RA or omega-3 fatty acids for OA. Whether any of these supplements can be effectively and safely recommended to reduce nonsteroidal antiinflammatory drug or steroid usage is unclear and requires more high-quality research.

Authors+Show Affiliations

Bethesda North Hospital Pharmacy, Cincinnati, Ohio, USA. drcathy@rxintegrativesolutions.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20232616

Citation

Rosenbaum, Cathy Creger, et al. "Antioxidants and Antiinflammatory Dietary Supplements for Osteoarthritis and Rheumatoid Arthritis." Alternative Therapies in Health and Medicine, vol. 16, no. 2, 2010, pp. 32-40.
Rosenbaum CC, O'Mathúna DP, Chavez M, et al. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern Ther Health Med. 2010;16(2):32-40.
Rosenbaum, C. C., O'Mathúna, D. P., Chavez, M., & Shields, K. (2010). Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Alternative Therapies in Health and Medicine, 16(2), pp. 32-40.
Rosenbaum CC, et al. Antioxidants and Antiinflammatory Dietary Supplements for Osteoarthritis and Rheumatoid Arthritis. Altern Ther Health Med. 2010;16(2):32-40. PubMed PMID: 20232616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. AU - Rosenbaum,Cathy Creger, AU - O'Mathúna,Dónal P, AU - Chavez,Mary, AU - Shields,Kelly, PY - 2010/3/18/entrez PY - 2010/3/18/pubmed PY - 2010/4/21/medline SP - 32 EP - 40 JF - Alternative therapies in health and medicine JO - Altern Ther Health Med VL - 16 IS - 2 N2 - OBJECTIVE: To review efficacy studies of antioxidant and antiinflammatory dietary supplements used to manage osteoarthritis (OA) and rheumatoid arthritis (RA) and make conclusions about their place in therapy. Glucosamine, chondroitin, and methyl sulfonyl methane were excluded. DATA SOURCES: A literature search was conducted using MEDLINE (1996 through January 2009), EMBASE, Cochrane Library, Natural Medicines Comprehensive Database, and Natural Standard, with bibliographic review of relevant articles. Cited studies from before our search range were included if they represented the only published human data available. Search words included "antioxidant," "antiinflammatory," "cat's claw," "ginger," "fish oil," "omega-3," "turmeric," "vitamin E," "vitamin C," "Baikal skullcap," "barberry," "Chinese goldthread," "green tea," "Indian holy basil," "hu zhang,""oregano," and"rosemary." STUDY SELECTION AND DATA EXTRACTION: Efficacy studies published in English were included provided they evaluated the dietary supplements in patients with OA or RA. DATA SYNTHESIS: Our search strategy yielded 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study) in addition to one meta-analysis and one review article. CONCLUSIONS: Three studies support cat's claw alone or in combination for OA, and two studies support omega-3 fatty acids for the treatment of RA. We cannot recommend use of vitamin E alone; vitamins A, C, and E in combination; ginger; turmeric; or Zyflamend (New Chapter, Brattleboro, Vermont) for the treatment of OA or RA or omega-3 fatty acids for OA. Whether any of these supplements can be effectively and safely recommended to reduce nonsteroidal antiinflammatory drug or steroid usage is unclear and requires more high-quality research. SN - 1078-6791 UR - https://www.unboundmedicine.com/medline/citation/20232616/Antioxidants_and_antiinflammatory_dietary_supplements_for_osteoarthritis_and_rheumatoid_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -