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Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract.

Abstract

BACKGROUND

Grass pollen allergy is one of the most common allergies worldwide, and patients often show sensitization to an array of phylogenetically related species.

OBJECTIVE

To determine the effect of specific immunotherapy (SIT) with Phleum pratense extract on induction of the immune response to a mixture composed of 5 grass pollen extracts.

METHODS

Forty-six adult patients suffering from rhinitis and sensitized to a mix of grass pollen allergen extracts were randomized 3:1 to receive a short course of SIT with P. pratense or to an open control group without SIT. At baseline and after 3-4 months, we evaluated levels of specific immunoglobulin (Ig) E and IgG4, as well as the immediate and delayed cutaneous responses to the grass mix and P. pratense. IgG4 to Lolium perenne was also determined.

RESULTS

Levels of IgE and IgG4 to grass mix and P. pratense increased significantly during treatment (P<.001). However, this increase was only significantly higher in the SIT group than in the control group for IgG4 (P<.001). The levels of IgG4 to Phl p 5 and Lol p 5 were highly correlated (r=0.99, P<.001). The immediate and delayed cutaneous responses were significantly diminished to both extracts after SIT (P<.001).

CONCLUSIONS

Patients with rhinoconjunctivitis diagnosed using skin prick testing with a grass mix allergen extract and treated with a short course of SIT based on a single species P. pratense allergen extract are able to develop an immune response that targets not only the immunizing species, but also the grass mix allergen extract.

Authors+Show Affiliations

Allergy Department, Hospital Clínico Universitario San Carlos, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

20232769

Citation

Martínez-Cócera, C, et al. "Immunotherapy With a Phleum Pratense Allergen Extract Induces an Immune Response to a Grass-mix Allergen Extract." Journal of Investigational Allergology & Clinical Immunology, vol. 20, no. 1, 2010, pp. 13-9.
Martínez-Cócera C, Sastre J, Cimarra M, et al. Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract. J Investig Allergol Clin Immunol. 2010;20(1):13-9.
Martínez-Cócera, C., Sastre, J., Cimarra, M., Quirce, S., Fernández-Rivas, M., Enríquez-Matas, A., Rodríguez-Alvarez, M., & Martín, S. (2010). Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract. Journal of Investigational Allergology & Clinical Immunology, 20(1), 13-9.
Martínez-Cócera C, et al. Immunotherapy With a Phleum Pratense Allergen Extract Induces an Immune Response to a Grass-mix Allergen Extract. J Investig Allergol Clin Immunol. 2010;20(1):13-9. PubMed PMID: 20232769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunotherapy with a Phleum pratense allergen extract induces an immune response to a grass-mix allergen extract. AU - Martínez-Cócera,C, AU - Sastre,J, AU - Cimarra,M, AU - Quirce,S, AU - Fernández-Rivas,M, AU - Enríquez-Matas,A, AU - Rodríguez-Alvarez,M, AU - Martín,S, PY - 2010/3/18/entrez PY - 2010/3/18/pubmed PY - 2010/4/9/medline SP - 13 EP - 9 JF - Journal of investigational allergology & clinical immunology JO - J Investig Allergol Clin Immunol VL - 20 IS - 1 N2 - BACKGROUND: Grass pollen allergy is one of the most common allergies worldwide, and patients often show sensitization to an array of phylogenetically related species. OBJECTIVE: To determine the effect of specific immunotherapy (SIT) with Phleum pratense extract on induction of the immune response to a mixture composed of 5 grass pollen extracts. METHODS: Forty-six adult patients suffering from rhinitis and sensitized to a mix of grass pollen allergen extracts were randomized 3:1 to receive a short course of SIT with P. pratense or to an open control group without SIT. At baseline and after 3-4 months, we evaluated levels of specific immunoglobulin (Ig) E and IgG4, as well as the immediate and delayed cutaneous responses to the grass mix and P. pratense. IgG4 to Lolium perenne was also determined. RESULTS: Levels of IgE and IgG4 to grass mix and P. pratense increased significantly during treatment (P<.001). However, this increase was only significantly higher in the SIT group than in the control group for IgG4 (P<.001). The levels of IgG4 to Phl p 5 and Lol p 5 were highly correlated (r=0.99, P<.001). The immediate and delayed cutaneous responses were significantly diminished to both extracts after SIT (P<.001). CONCLUSIONS: Patients with rhinoconjunctivitis diagnosed using skin prick testing with a grass mix allergen extract and treated with a short course of SIT based on a single species P. pratense allergen extract are able to develop an immune response that targets not only the immunizing species, but also the grass mix allergen extract. SN - 1018-9068 UR - https://www.unboundmedicine.com/medline/citation/20232769/Immunotherapy_with_a_Phleum_pratense_allergen_extract_induces_an_immune_response_to_a_grass_mix_allergen_extract_ L2 - http://www.jiaci.org/issues/vol20issue1/vol20issue01-3.htm DB - PRIME DP - Unbound Medicine ER -