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Immunogenicity of standard dose Edmonston-Zagreb measles vaccine in highland Papua New Guinean children from four months of age.
J Trop Med Hyg. 1991 Apr; 94(2):88-91.JT

Abstract

A small-scale trial was carried out at Tari in the Southern Highlands Province of Papua New Guinea to determine the effectiveness of a standard subcutaneous dose of Edmonston-Zagreb measles vaccine (Institute of Immunology, Zagreb) administered to children at less than 8 months of age. Specific antibody levels were measured before and 7-11 weeks after vaccination using an ELISA system. Paired sera from 41 children vaccinated at 4-7 months of age and from 18 children vaccinated routinely at 8-29 months of age were available for comparison. No child 6 months of age or older had detectable maternal antibodies and all of these seroconverted. Post-vaccination titres in 12 children aged 6-7 months were not significantly different from those in older children and 1 year later, post-vaccination titres were still high. In Papua New Guinea, and perhaps in other developing countries, it may prove appropriate and acceptable to vaccinate with Edmonston-Zagreb measles vaccine at 6 months of age without recourse to augmentation of dose from that currently recommended in older children.

Authors+Show Affiliations

Papua New Guinea Institute of Medical Research, Tari.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2023293

Citation

Rogers, S, et al. "Immunogenicity of Standard Dose Edmonston-Zagreb Measles Vaccine in Highland Papua New Guinean Children From Four Months of Age." The Journal of Tropical Medicine and Hygiene, vol. 94, no. 2, 1991, pp. 88-91.
Rogers S, Sanders RC, Alpers MP. Immunogenicity of standard dose Edmonston-Zagreb measles vaccine in highland Papua New Guinean children from four months of age. J Trop Med Hyg. 1991;94(2):88-91.
Rogers, S., Sanders, R. C., & Alpers, M. P. (1991). Immunogenicity of standard dose Edmonston-Zagreb measles vaccine in highland Papua New Guinean children from four months of age. The Journal of Tropical Medicine and Hygiene, 94(2), 88-91.
Rogers S, Sanders RC, Alpers MP. Immunogenicity of Standard Dose Edmonston-Zagreb Measles Vaccine in Highland Papua New Guinean Children From Four Months of Age. J Trop Med Hyg. 1991;94(2):88-91. PubMed PMID: 2023293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of standard dose Edmonston-Zagreb measles vaccine in highland Papua New Guinean children from four months of age. AU - Rogers,S, AU - Sanders,R C, AU - Alpers,M P, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 88 EP - 91 JF - The Journal of tropical medicine and hygiene JO - J Trop Med Hyg VL - 94 IS - 2 N2 - A small-scale trial was carried out at Tari in the Southern Highlands Province of Papua New Guinea to determine the effectiveness of a standard subcutaneous dose of Edmonston-Zagreb measles vaccine (Institute of Immunology, Zagreb) administered to children at less than 8 months of age. Specific antibody levels were measured before and 7-11 weeks after vaccination using an ELISA system. Paired sera from 41 children vaccinated at 4-7 months of age and from 18 children vaccinated routinely at 8-29 months of age were available for comparison. No child 6 months of age or older had detectable maternal antibodies and all of these seroconverted. Post-vaccination titres in 12 children aged 6-7 months were not significantly different from those in older children and 1 year later, post-vaccination titres were still high. In Papua New Guinea, and perhaps in other developing countries, it may prove appropriate and acceptable to vaccinate with Edmonston-Zagreb measles vaccine at 6 months of age without recourse to augmentation of dose from that currently recommended in older children. SN - 0022-5304 UR - https://www.unboundmedicine.com/medline/citation/2023293/Immunogenicity_of_standard_dose_Edmonston_Zagreb_measles_vaccine_in_highland_Papua_New_Guinean_children_from_four_months_of_age_ L2 - https://www.diseaseinfosearch.org/result/4535 DB - PRIME DP - Unbound Medicine ER -