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The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population.
BMC Public Health. 2010 Mar 17; 10:139.BP

Abstract

BACKGROUND

Different populations have diverse patterns of relationships between Impaired Fasting Glucose (IFG) and obesity and lipid markers, it is important to investigate the characteristics of associations between IFG and other related risk factors including body mass index (BMI), waist circumstance (WC), serum lipids and blood pressure (BP) in a Chinese population.

METHODS

This was a case-control study of 648 IFG subjects and 1,296 controls derived from a large-scale, community-based, cross-sectional survey of 10,867 participants. Each subject received a face-to-face interview, physical examination, and blood tests, including fasting blood glucose and lipids. Student's t-test, Chi-square test, Spearman correlation and multiple logistic regressions were used for the statistical analyses.

RESULTS

Fasting plasma glucose (FPG) was positively correlated with BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), and total cholesterol (TC), and was negatively correlated with high density lipoprotein-cholesterol (HDL-C) (all p < 0.05). BMI was more strongly correlated with IFG than with WC. The correlation coefficient of FPG was remarkably higher with TG (0.244) than with TC (0.134) and HDL-C (-0.192). TG was an important predictor of IFG, with odds ratios of 1.76 (95%CI: 1.31-2.36) for subjects with borderline high TG level (1.70 mmol/l < or = TG < 2.26 mmol/l) and 3.13 (95% CI: 2.50-3.91) for those with higher TG level (TG > or = 2.26 mmol/l), when comparing to subjects with TG < 1.70 mmol/l. There was a significant dose-response relationship between the number of abnormal variables and increased risk of IFG.

CONCLUSIONS

In this Chinese population, both BMI and WC were important predictors of IFG. Abnormal TG as a lipid marker was more strongly associated with IFG than were TC and HDL-C. These factors should be taken into consideration simultaneously for prevention of IFG.

Authors+Show Affiliations

Department of Disease Control and Prevention, Wuxi Center for Disease Prevention and Control, Wuxi 214023, Jiangsu, China. dr_yunqian@yahoo.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20233452

Citation

Qian, Yun, et al. "The Characteristics of Impaired Fasting Glucose Associated With Obesity and Dyslipidaemia in a Chinese Population." BMC Public Health, vol. 10, 2010, p. 139.
Qian Y, Lin Y, Zhang T, et al. The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population. BMC Public Health. 2010;10:139.
Qian, Y., Lin, Y., Zhang, T., Bai, J., Chen, F., Zhang, Y., Luo, S., & Shen, H. (2010). The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population. BMC Public Health, 10, 139. https://doi.org/10.1186/1471-2458-10-139
Qian Y, et al. The Characteristics of Impaired Fasting Glucose Associated With Obesity and Dyslipidaemia in a Chinese Population. BMC Public Health. 2010 Mar 17;10:139. PubMed PMID: 20233452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population. AU - Qian,Yun, AU - Lin,Yudi, AU - Zhang,Tiemei, AU - Bai,Jianling, AU - Chen,Feng, AU - Zhang,Yi, AU - Luo,Senlin, AU - Shen,Hongbing, Y1 - 2010/03/17/ PY - 2009/09/04/received PY - 2010/03/17/accepted PY - 2010/3/18/entrez PY - 2010/3/18/pubmed PY - 2011/9/15/medline SP - 139 EP - 139 JF - BMC public health JO - BMC Public Health VL - 10 N2 - BACKGROUND: Different populations have diverse patterns of relationships between Impaired Fasting Glucose (IFG) and obesity and lipid markers, it is important to investigate the characteristics of associations between IFG and other related risk factors including body mass index (BMI), waist circumstance (WC), serum lipids and blood pressure (BP) in a Chinese population. METHODS: This was a case-control study of 648 IFG subjects and 1,296 controls derived from a large-scale, community-based, cross-sectional survey of 10,867 participants. Each subject received a face-to-face interview, physical examination, and blood tests, including fasting blood glucose and lipids. Student's t-test, Chi-square test, Spearman correlation and multiple logistic regressions were used for the statistical analyses. RESULTS: Fasting plasma glucose (FPG) was positively correlated with BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), and total cholesterol (TC), and was negatively correlated with high density lipoprotein-cholesterol (HDL-C) (all p < 0.05). BMI was more strongly correlated with IFG than with WC. The correlation coefficient of FPG was remarkably higher with TG (0.244) than with TC (0.134) and HDL-C (-0.192). TG was an important predictor of IFG, with odds ratios of 1.76 (95%CI: 1.31-2.36) for subjects with borderline high TG level (1.70 mmol/l < or = TG < 2.26 mmol/l) and 3.13 (95% CI: 2.50-3.91) for those with higher TG level (TG > or = 2.26 mmol/l), when comparing to subjects with TG < 1.70 mmol/l. There was a significant dose-response relationship between the number of abnormal variables and increased risk of IFG. CONCLUSIONS: In this Chinese population, both BMI and WC were important predictors of IFG. Abnormal TG as a lipid marker was more strongly associated with IFG than were TC and HDL-C. These factors should be taken into consideration simultaneously for prevention of IFG. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/20233452/The_characteristics_of_impaired_fasting_glucose_associated_with_obesity_and_dyslipidaemia_in_a_Chinese_population_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-10-139 DB - PRIME DP - Unbound Medicine ER -