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Inhaled fluticasone propionate reduces postoperative sore throat, cough, and hoarseness.
Anesth Analg. 2010 Oct; 111(4):895-8.A&A

Abstract

BACKGROUND

Sore throat is a common complication after surgery. Postoperative cough and hoarseness can also be distressing to patients. We sought to determine the effect of an inhaler steroid on sore throat, cough, and hoarseness during the first 24 hours of the postoperative period.

METHODS

We enrolled 120 women with ASA physical status I or II and term singleton pregnancy who were scheduled for elective cesarean delivery under general anesthesia. Patients were randomized into 2 groups: in the sitting position, group F patients received 500 μg inhaled fluticasone propionate via a spacer device during 2 deep inspirations, after arrival in the operating room, and group C had no treatment. The patients were interviewed by a blinded investigator for postoperative sore throat, cough, and hoarseness at 1 and 24 hours after surgery.

RESULTS

There were no significant differences in age, height, weight, body mass index, duration of surgery, intubation, and grade of laryngeal exposure between the 2 groups. The incidence of sore throat, cough, and hoarseness was significantly lower in group F (3.33%, 3.33%, and 3.33%) compared with the control group (36.67%, 18.33%, and 35%) (P < 0.05 for all comparisons), not only in the first postoperative hour but also 24 hours after surgery (13.33%, 13.33%, and 25% in group F vs 40%, 41.67%, and 50% in the control group). The incidence of moderate and severe hoarseness in group F at the first hour was significantly less than the control group (P < 0.05).

CONCLUSIONS

Inhaled fluticasone propionate decreases the incidence and severity of postoperative sore throat, cough, and hoarseness in patients undergoing cesarean delivery under general anesthesia.

Authors+Show Affiliations

Roointan-Arash Hospital, Tehranpars, Tehran, Iran. nfaridi@sina.tums.ac.irNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20237046

Citation

Tazeh-Kand, Nasrin Faridi, et al. "Inhaled Fluticasone Propionate Reduces Postoperative Sore Throat, Cough, and Hoarseness." Anesthesia and Analgesia, vol. 111, no. 4, 2010, pp. 895-8.
Tazeh-Kand NF, Eslami B, Mohammadian K. Inhaled fluticasone propionate reduces postoperative sore throat, cough, and hoarseness. Anesth Analg. 2010;111(4):895-8.
Tazeh-Kand, N. F., Eslami, B., & Mohammadian, K. (2010). Inhaled fluticasone propionate reduces postoperative sore throat, cough, and hoarseness. Anesthesia and Analgesia, 111(4), 895-8. https://doi.org/10.1213/ANE.0b013e3181c8a5a2
Tazeh-Kand NF, Eslami B, Mohammadian K. Inhaled Fluticasone Propionate Reduces Postoperative Sore Throat, Cough, and Hoarseness. Anesth Analg. 2010;111(4):895-8. PubMed PMID: 20237046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhaled fluticasone propionate reduces postoperative sore throat, cough, and hoarseness. AU - Tazeh-Kand,Nasrin Faridi, AU - Eslami,Bita, AU - Mohammadian,Khadijeh, Y1 - 2010/03/17/ PY - 2010/3/19/entrez PY - 2010/3/20/pubmed PY - 2010/10/12/medline SP - 895 EP - 8 JF - Anesthesia and analgesia JO - Anesth Analg VL - 111 IS - 4 N2 - BACKGROUND: Sore throat is a common complication after surgery. Postoperative cough and hoarseness can also be distressing to patients. We sought to determine the effect of an inhaler steroid on sore throat, cough, and hoarseness during the first 24 hours of the postoperative period. METHODS: We enrolled 120 women with ASA physical status I or II and term singleton pregnancy who were scheduled for elective cesarean delivery under general anesthesia. Patients were randomized into 2 groups: in the sitting position, group F patients received 500 μg inhaled fluticasone propionate via a spacer device during 2 deep inspirations, after arrival in the operating room, and group C had no treatment. The patients were interviewed by a blinded investigator for postoperative sore throat, cough, and hoarseness at 1 and 24 hours after surgery. RESULTS: There were no significant differences in age, height, weight, body mass index, duration of surgery, intubation, and grade of laryngeal exposure between the 2 groups. The incidence of sore throat, cough, and hoarseness was significantly lower in group F (3.33%, 3.33%, and 3.33%) compared with the control group (36.67%, 18.33%, and 35%) (P < 0.05 for all comparisons), not only in the first postoperative hour but also 24 hours after surgery (13.33%, 13.33%, and 25% in group F vs 40%, 41.67%, and 50% in the control group). The incidence of moderate and severe hoarseness in group F at the first hour was significantly less than the control group (P < 0.05). CONCLUSIONS: Inhaled fluticasone propionate decreases the incidence and severity of postoperative sore throat, cough, and hoarseness in patients undergoing cesarean delivery under general anesthesia. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/20237046/Inhaled_fluticasone_propionate_reduces_postoperative_sore_throat_cough_and_hoarseness_ L2 - https://doi.org/10.1213/ANE.0b013e3181c8a5a2 DB - PRIME DP - Unbound Medicine ER -