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Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects.
Alcohol Clin Exp Res 1991; 15(1):94-101AC

Abstract

Response differences following administration of alcohol between adult males with a positive (FHP) versus negative (FHN) family history of alcoholism have been demonstrated in previous research and are thought to be related to risk for developing alcoholism. If this is so, the pharmacological breadth of addiction risk conferred by a positive family alcoholism history might be studied by determining whether FHP subjects show different responses than FHN to drug classes other than alcohol. We have previously reported on the acute effects of ethanol as compared with secobarbital in FHP and FHN subjects and found that FHP subjects showed greater sensitivity across a variety of subjective measures than FHN subjects for both drug classes. The data reported here are based on an extended data collection period of 3 to 18 hr postingestion, following completion of the acute laboratory portion of the study. Specifically, in the present study, dose-effect timecourse functions for a variety of physiological (heart rate, blood pressure, and breath alcohol level), subjective (analog mood, drug effect, and withdrawal, Subjective High Assessment Scale (SHAS], and psychomotor measures (Digit Symbol Substitution Test and numeric recall) were examined in FHP and FHN college-aged males for secobarbital (0, 100, 200 mg daily) and ethanol (1 g/kg daily). FHP and FHN subjects were matched on light-to-moderate drinking patterns, anthropometric dimensions, age, years of schooling, and drug use. FHP subjects reported more extended intoxication and greater withdrawal effects following both ethanol and the high dose of secobarbital than did FHN subjects.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2024739

Citation

McCaul, M E., et al. "Alcohol and Secobarbital Effects as a Function of Familial Alcoholism: Extended Intoxication and Increased Withdrawal Effects." Alcoholism, Clinical and Experimental Research, vol. 15, no. 1, 1991, pp. 94-101.
McCaul ME, Turkkan JS, Svikis DS, et al. Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects. Alcohol Clin Exp Res. 1991;15(1):94-101.
McCaul, M. E., Turkkan, J. S., Svikis, D. S., & Bigelow, G. E. (1991). Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects. Alcoholism, Clinical and Experimental Research, 15(1), pp. 94-101.
McCaul ME, et al. Alcohol and Secobarbital Effects as a Function of Familial Alcoholism: Extended Intoxication and Increased Withdrawal Effects. Alcohol Clin Exp Res. 1991;15(1):94-101. PubMed PMID: 2024739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects. AU - McCaul,M E, AU - Turkkan,J S, AU - Svikis,D S, AU - Bigelow,G E, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 94 EP - 101 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 15 IS - 1 N2 - Response differences following administration of alcohol between adult males with a positive (FHP) versus negative (FHN) family history of alcoholism have been demonstrated in previous research and are thought to be related to risk for developing alcoholism. If this is so, the pharmacological breadth of addiction risk conferred by a positive family alcoholism history might be studied by determining whether FHP subjects show different responses than FHN to drug classes other than alcohol. We have previously reported on the acute effects of ethanol as compared with secobarbital in FHP and FHN subjects and found that FHP subjects showed greater sensitivity across a variety of subjective measures than FHN subjects for both drug classes. The data reported here are based on an extended data collection period of 3 to 18 hr postingestion, following completion of the acute laboratory portion of the study. Specifically, in the present study, dose-effect timecourse functions for a variety of physiological (heart rate, blood pressure, and breath alcohol level), subjective (analog mood, drug effect, and withdrawal, Subjective High Assessment Scale (SHAS], and psychomotor measures (Digit Symbol Substitution Test and numeric recall) were examined in FHP and FHN college-aged males for secobarbital (0, 100, 200 mg daily) and ethanol (1 g/kg daily). FHP and FHN subjects were matched on light-to-moderate drinking patterns, anthropometric dimensions, age, years of schooling, and drug use. FHP subjects reported more extended intoxication and greater withdrawal effects following both ethanol and the high dose of secobarbital than did FHN subjects.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/2024739/Alcohol_and_secobarbital_effects_as_a_function_of_familial_alcoholism:_extended_intoxication_and_increased_withdrawal_effects_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1991&volume=15&issue=1&spage=94 DB - PRIME DP - Unbound Medicine ER -