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Effects of urine acidification on plasma and urine phencyclidine levels in overdosage.
Clin Pharmacol Ther. 1977 Oct; 22(4):421-4.CP

Abstract

A gas chromatography--mass fragmentography--electron impact (GC-MS-EI) assay of phencyclidine (PCP) was adapted for human plasma and urine. This assay is specific for PCP and very sensitive (approximately 1 ng/ml). Patients with the putative diagnosis of PCP overdosage were studied to correlate plasma and urinary levels with clinical state. Urinary PCP levels were enhanced in an acid urine, which suggests that acidification of the urine is an adjunct in the therapy of PCP overdosage.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20261

Citation

Domino, E F., and A E. Wilson. "Effects of Urine Acidification On Plasma and Urine Phencyclidine Levels in Overdosage." Clinical Pharmacology and Therapeutics, vol. 22, no. 4, 1977, pp. 421-4.
Domino EF, Wilson AE. Effects of urine acidification on plasma and urine phencyclidine levels in overdosage. Clin Pharmacol Ther. 1977;22(4):421-4.
Domino, E. F., & Wilson, A. E. (1977). Effects of urine acidification on plasma and urine phencyclidine levels in overdosage. Clinical Pharmacology and Therapeutics, 22(4), 421-4.
Domino EF, Wilson AE. Effects of Urine Acidification On Plasma and Urine Phencyclidine Levels in Overdosage. Clin Pharmacol Ther. 1977;22(4):421-4. PubMed PMID: 20261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of urine acidification on plasma and urine phencyclidine levels in overdosage. AU - Domino,E F, AU - Wilson,A E, PY - 1977/10/1/pubmed PY - 1977/10/1/medline PY - 1977/10/1/entrez SP - 421 EP - 4 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 22 IS - 4 N2 - A gas chromatography--mass fragmentography--electron impact (GC-MS-EI) assay of phencyclidine (PCP) was adapted for human plasma and urine. This assay is specific for PCP and very sensitive (approximately 1 ng/ml). Patients with the putative diagnosis of PCP overdosage were studied to correlate plasma and urinary levels with clinical state. Urinary PCP levels were enhanced in an acid urine, which suggests that acidification of the urine is an adjunct in the therapy of PCP overdosage. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/20261/Effects_of_urine_acidification_on_plasma_and_urine_phencyclidine_levels_in_overdosage_ L2 - http://hdl.handle.net/2027.42/117118 DB - PRIME DP - Unbound Medicine ER -