Tags

Type your tag names separated by a space and hit enter

A semiclosed-loop algorithm for the control of blood glucose levels in diabetics.
IEEE Trans Biomed Eng. 1991 Jan; 38(1):57-61.IT

Abstract

In this paper, a theoretical analysis of the control of plasma glucose levels in diabetic individuals is undertaken using a simple mathematical model of the dynamics of glucose and insulin interaction in the blood system. Mathematical optimization techniques are applied to the mathematical model to derive insulin infusion programs for the control of blood levels in diabetic individuals. Based on the results of the mathematical optimization, a semiclosed-loop algorithm is proposed for continuous insulin delivery to diabetic patients. The algorithm is based on three hourly plasma glucose samples. A theoretical evaluation of the effectiveness of this algorithm shows that it is superior to two existing algorithms in controlling hyperglycemia. A glucose infusion term representing the effect of glucose intake resulting from a meal is then introduced into the model equations. Various insulin infusion programs for the control of plasma glucose levels following a meal are then assessed. The theoretical results suggest that the most effective short-term control is achieved by an insulin infusion program which incorporates an injection to coincide with the meal.

Authors+Show Affiliations

Department of Mathematics, University of Western Australia, Nedlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2026432

Citation

Fisher, M E.. "A Semiclosed-loop Algorithm for the Control of Blood Glucose Levels in Diabetics." IEEE Transactions On Bio-medical Engineering, vol. 38, no. 1, 1991, pp. 57-61.
Fisher ME. A semiclosed-loop algorithm for the control of blood glucose levels in diabetics. IEEE Trans Biomed Eng. 1991;38(1):57-61.
Fisher, M. E. (1991). A semiclosed-loop algorithm for the control of blood glucose levels in diabetics. IEEE Transactions On Bio-medical Engineering, 38(1), 57-61.
Fisher ME. A Semiclosed-loop Algorithm for the Control of Blood Glucose Levels in Diabetics. IEEE Trans Biomed Eng. 1991;38(1):57-61. PubMed PMID: 2026432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A semiclosed-loop algorithm for the control of blood glucose levels in diabetics. A1 - Fisher,M E, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 57 EP - 61 JF - IEEE transactions on bio-medical engineering JO - IEEE Trans Biomed Eng VL - 38 IS - 1 N2 - In this paper, a theoretical analysis of the control of plasma glucose levels in diabetic individuals is undertaken using a simple mathematical model of the dynamics of glucose and insulin interaction in the blood system. Mathematical optimization techniques are applied to the mathematical model to derive insulin infusion programs for the control of blood levels in diabetic individuals. Based on the results of the mathematical optimization, a semiclosed-loop algorithm is proposed for continuous insulin delivery to diabetic patients. The algorithm is based on three hourly plasma glucose samples. A theoretical evaluation of the effectiveness of this algorithm shows that it is superior to two existing algorithms in controlling hyperglycemia. A glucose infusion term representing the effect of glucose intake resulting from a meal is then introduced into the model equations. Various insulin infusion programs for the control of plasma glucose levels following a meal are then assessed. The theoretical results suggest that the most effective short-term control is achieved by an insulin infusion program which incorporates an injection to coincide with the meal. SN - 0018-9294 UR - https://www.unboundmedicine.com/medline/citation/2026432/A_semiclosed_loop_algorithm_for_the_control_of_blood_glucose_levels_in_diabetics_ L2 - https://doi.org/10.1109/10.68209 DB - PRIME DP - Unbound Medicine ER -