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Erythropoiesis and erythropoietin levels in renal transplant recipients.
Klin Wochenschr. 1991 Jan 22; 69(2):53-8.KW

Abstract

Moderately increased blood levels of endogenous erythropoietin (Epo) usually induce complete restoration of renal anemia after successful kidney transplantation. With good graft function erythropoiesis is maintained by normal Epo serum levels. Persistent anemia can be related to iron deficiency, low excretory graft function, and high dosage of immunosuppressive agents leading to marrow suppression or nephrotoxicity. Acute early rejection is associated with a fall in serum Epo and abrogation of reticulocytosis. About 15% of recipients fail to exhibit the normal feedback regulation and develop a mostly transient posttransplant erythrocytosis. Both an increased sensitivity of erythrocytic progenitors to Epo and inappropriate Epo secretion by the native kidneys may account for this overshooting reaction.

Authors+Show Affiliations

Physiologisches Institut I, Friedrich-Wilhelms-Universität Bonn.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2027270

Citation

Wolff, M, and W Jelkmann. "Erythropoiesis and Erythropoietin Levels in Renal Transplant Recipients." Klinische Wochenschrift, vol. 69, no. 2, 1991, pp. 53-8.
Wolff M, Jelkmann W. Erythropoiesis and erythropoietin levels in renal transplant recipients. Klin Wochenschr. 1991;69(2):53-8.
Wolff, M., & Jelkmann, W. (1991). Erythropoiesis and erythropoietin levels in renal transplant recipients. Klinische Wochenschrift, 69(2), 53-8.
Wolff M, Jelkmann W. Erythropoiesis and Erythropoietin Levels in Renal Transplant Recipients. Klin Wochenschr. 1991 Jan 22;69(2):53-8. PubMed PMID: 2027270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythropoiesis and erythropoietin levels in renal transplant recipients. AU - Wolff,M, AU - Jelkmann,W, PY - 1991/1/22/pubmed PY - 1991/1/22/medline PY - 1991/1/22/entrez SP - 53 EP - 8 JF - Klinische Wochenschrift JO - Klin Wochenschr VL - 69 IS - 2 N2 - Moderately increased blood levels of endogenous erythropoietin (Epo) usually induce complete restoration of renal anemia after successful kidney transplantation. With good graft function erythropoiesis is maintained by normal Epo serum levels. Persistent anemia can be related to iron deficiency, low excretory graft function, and high dosage of immunosuppressive agents leading to marrow suppression or nephrotoxicity. Acute early rejection is associated with a fall in serum Epo and abrogation of reticulocytosis. About 15% of recipients fail to exhibit the normal feedback regulation and develop a mostly transient posttransplant erythrocytosis. Both an increased sensitivity of erythrocytic progenitors to Epo and inappropriate Epo secretion by the native kidneys may account for this overshooting reaction. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2027270/Erythropoiesis_and_erythropoietin_levels_in_renal_transplant_recipients_ L2 - https://medlineplus.gov/kidneytransplantation.html DB - PRIME DP - Unbound Medicine ER -