Tags

Type your tag names separated by a space and hit enter

Early diagnosis of Parkinson's disease: recommendations from diagnostic clinical guidelines.
Am J Manag Care. 2010 Mar; 16 Suppl Implications:S94-9.AJ

Abstract

Therapeutic options for Parkinson's disease (PD) are currently limited to symptomatic agents. Levodopa is the most efficacious treatment; however, higher doses and long-term use are associated with adverse effects such as motor fluctuations and dyskinesia. Early treatment of PD with other agents such as dopamine agonists and monoamine oxidase type B inhibitors can provide symptomatic benefit and delay initiation of levodopa therapy. Early treatment of PD is contingent upon early and accurate diagnosis of the disease, which can be challenging because there are no biomarkers or neuroimaging or other clinical tests available to confirm the diagnosis. PD diagnosis is currently based on the presence or absence of various clinical features and the experience of the treating physician. A definitive diagnosis can be made only after autopsy. Moreover, the signs and symptoms present in early PD can resemble those of a number of other movement disorders, particularly other forms of parkinsonism, such as multiple system atrophy, drug-induced parkinsonism, and vascular parkinsonism, as well as diffuse Lewy body disease and essential tremor. Nevertheless, diagnosis of PD based on clinical features and response to antiparkinsonian medication can be achieved with a fairly high level of accuracy, particularly when made by a physician specializing in movement disorders. This article reviews and summarizes published recommendations for the clinical diagnosis of PD.

Authors+Show Affiliations

University of Kansas Medical Center, 3599 Rainbow Blvd., Kansas City, KS 66160, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20297872

Citation

Pahwa, Rajesh, and Kelly E. Lyons. "Early Diagnosis of Parkinson's Disease: Recommendations From Diagnostic Clinical Guidelines." The American Journal of Managed Care, vol. 16 Suppl Implications, 2010, pp. S94-9.
Pahwa R, Lyons KE. Early diagnosis of Parkinson's disease: recommendations from diagnostic clinical guidelines. Am J Manag Care. 2010;16 Suppl Implications:S94-9.
Pahwa, R., & Lyons, K. E. (2010). Early diagnosis of Parkinson's disease: recommendations from diagnostic clinical guidelines. The American Journal of Managed Care, 16 Suppl Implications, S94-9.
Pahwa R, Lyons KE. Early Diagnosis of Parkinson's Disease: Recommendations From Diagnostic Clinical Guidelines. Am J Manag Care. 2010;16 Suppl Implications:S94-9. PubMed PMID: 20297872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early diagnosis of Parkinson's disease: recommendations from diagnostic clinical guidelines. AU - Pahwa,Rajesh, AU - Lyons,Kelly E, PY - 2010/3/20/entrez PY - 2010/3/30/pubmed PY - 2010/6/15/medline SP - S94 EP - 9 JF - The American journal of managed care JO - Am J Manag Care VL - 16 Suppl Implications N2 - Therapeutic options for Parkinson's disease (PD) are currently limited to symptomatic agents. Levodopa is the most efficacious treatment; however, higher doses and long-term use are associated with adverse effects such as motor fluctuations and dyskinesia. Early treatment of PD with other agents such as dopamine agonists and monoamine oxidase type B inhibitors can provide symptomatic benefit and delay initiation of levodopa therapy. Early treatment of PD is contingent upon early and accurate diagnosis of the disease, which can be challenging because there are no biomarkers or neuroimaging or other clinical tests available to confirm the diagnosis. PD diagnosis is currently based on the presence or absence of various clinical features and the experience of the treating physician. A definitive diagnosis can be made only after autopsy. Moreover, the signs and symptoms present in early PD can resemble those of a number of other movement disorders, particularly other forms of parkinsonism, such as multiple system atrophy, drug-induced parkinsonism, and vascular parkinsonism, as well as diffuse Lewy body disease and essential tremor. Nevertheless, diagnosis of PD based on clinical features and response to antiparkinsonian medication can be achieved with a fairly high level of accuracy, particularly when made by a physician specializing in movement disorders. This article reviews and summarizes published recommendations for the clinical diagnosis of PD. SN - 1936-2692 UR - https://www.unboundmedicine.com/medline/citation/20297872/Early_diagnosis_of_Parkinson's_disease:_recommendations_from_diagnostic_clinical_guidelines_ L2 - https://www.ajmc.com/pubMed.php?pii=12607 DB - PRIME DP - Unbound Medicine ER -