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Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study.
Clin Respir J 2009; 3(2):82-4CR

Abstract

BACKGROUND

Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma.

METHODS

Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry.

RESULTS

We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002.

CONCLUSIONS

Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma.

Authors+Show Affiliations

Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20298382

Citation

Thomsen, Simon Francis, et al. "Regular Use of Non-steroidal Anti-inflammatory Drugs Increases the Risk of Adult-onset Asthma: a Population-based Follow-up Study." The Clinical Respiratory Journal, vol. 3, no. 2, 2009, pp. 82-4.
Thomsen SF, Kyvik KO, Skadhauge LR, et al. Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study. Clin Respir J. 2009;3(2):82-4.
Thomsen, S. F., Kyvik, K. O., Skadhauge, L. R., Steffensen, I., & Backer, V. (2009). Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study. The Clinical Respiratory Journal, 3(2), pp. 82-4. doi:10.1111/j.1752-699X.2008.00113.x.
Thomsen SF, et al. Regular Use of Non-steroidal Anti-inflammatory Drugs Increases the Risk of Adult-onset Asthma: a Population-based Follow-up Study. Clin Respir J. 2009;3(2):82-4. PubMed PMID: 20298382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study. AU - Thomsen,Simon Francis, AU - Kyvik,Kirsten Ohm, AU - Skadhauge,Lars Rauff, AU - Steffensen,Ida, AU - Backer,Vibeke, PY - 2010/3/20/entrez PY - 2010/3/20/pubmed PY - 2010/6/26/medline SP - 82 EP - 4 JF - The clinical respiratory journal JO - Clin Respir J VL - 3 IS - 2 N2 - BACKGROUND: Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry. RESULTS: We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002. CONCLUSIONS: Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma. SN - 1752-699X UR - https://www.unboundmedicine.com/medline/citation/20298382/Regular_use_of_non_steroidal_anti_inflammatory_drugs_increases_the_risk_of_adult_onset_asthma:_a_population_based_follow_up_study_ L2 - https://doi.org/10.1111/j.1752-699X.2008.00113.x DB - PRIME DP - Unbound Medicine ER -