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A graphene-based electrochemical sensor for sensitive detection of paracetamol.
Talanta. 2010 May 15; 81(3):754-9.T

Abstract

An electrochemical sensor based on the electrocatalytic activity of functionalized graphene for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on graphene-modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry and square-wave voltammetry. The results showed that the graphene-modified electrode exhibited excellent electrocatalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained, and the over-potential of paracetamol decreased significantly compared with that at the bare GCE. Such electrocatalytic behavior of graphene is attributed to its unique physical and chemical properties, e.g., subtle electronic characteristics, attractive pi-pi interaction, and strong adsorptive capability. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 3.2x10(-8)M, a reproducibility of 5.2% relative standard deviation, and a satisfied recovery from 96.4% to 103.3%. The sensor shows great promise for simple, sensitive, and quantitative detection and screening of paracetamol.

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Authors+Show Affiliations

Kang X
Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Wang J
No affiliation info available
Wu H
No affiliation info available
Liu J
No affiliation info available
Aksay IA
No affiliation info available
Lin Y
No affiliation info available

MeSH

AcetaminophenAdsorptionCarbonCatalysisChemistry Techniques, AnalyticalChemistry, PharmaceuticalElectrochemistryElectrodesGraphiteLimit of DetectionModels, ChemicalOxidation-ReductionPharmaceutical PreparationsReproducibility of ResultsTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20298849

Citation

Kang, Xinhuang, et al. "A Graphene-based Electrochemical Sensor for Sensitive Detection of Paracetamol." Talanta, vol. 81, no. 3, 2010, pp. 754-9.
Kang X, Wang J, Wu H, et al. A graphene-based electrochemical sensor for sensitive detection of paracetamol. Talanta. 2010;81(3):754-9.
Kang, X., Wang, J., Wu, H., Liu, J., Aksay, I. A., & Lin, Y. (2010). A graphene-based electrochemical sensor for sensitive detection of paracetamol. Talanta, 81(3), 754-9. https://doi.org/10.1016/j.talanta.2010.01.009
Kang X, et al. A Graphene-based Electrochemical Sensor for Sensitive Detection of Paracetamol. Talanta. 2010 May 15;81(3):754-9. PubMed PMID: 20298849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A graphene-based electrochemical sensor for sensitive detection of paracetamol. AU - Kang,Xinhuang, AU - Wang,Jun, AU - Wu,Hong, AU - Liu,Jun, AU - Aksay,Ilhan A, AU - Lin,Yuehe, Y1 - 2010/01/25/ PY - 2009/10/29/received PY - 2010/01/07/revised PY - 2010/01/07/accepted PY - 2010/3/20/entrez PY - 2010/3/20/pubmed PY - 2010/10/27/medline SP - 754 EP - 9 JF - Talanta JO - Talanta VL - 81 IS - 3 N2 - An electrochemical sensor based on the electrocatalytic activity of functionalized graphene for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on graphene-modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry and square-wave voltammetry. The results showed that the graphene-modified electrode exhibited excellent electrocatalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained, and the over-potential of paracetamol decreased significantly compared with that at the bare GCE. Such electrocatalytic behavior of graphene is attributed to its unique physical and chemical properties, e.g., subtle electronic characteristics, attractive pi-pi interaction, and strong adsorptive capability. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 3.2x10(-8)M, a reproducibility of 5.2% relative standard deviation, and a satisfied recovery from 96.4% to 103.3%. The sensor shows great promise for simple, sensitive, and quantitative detection and screening of paracetamol. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/20298849/A_graphene_based_electrochemical_sensor_for_sensitive_detection_of_paracetamol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(10)00023-8 DB - PRIME DP - Unbound Medicine ER -