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Brazilian version of the Addenbrooke Cognitive Examination-revised in the diagnosis of mild Alzheimer disease.
Cogn Behav Neurol. 2010 Mar; 23(1):8-13.CB

Abstract

OBJECTIVE

To investigate the accuracy of the Brazilian version of the Addenbrooke Cognitive Examination-revised (ACE-R) in the diagnosis of mild Alzheimer disease (AD).

BACKGROUND

The ACE-R is an accurate and brief cognitive battery for the detection of mild dementia, especially for the discrimination between AD and frontotemporal dementia.

METHODS

The battery was administered to 31 patients with mild AD and 62 age-matched and education-matched cognitively healthy controls. Both groups were selected using the Dementia Rating Scale and were submitted to the ACE-R. Depression was ruled out in both groups by the Cornell Scale for Depression in Dementia. The performance of patients and controls in the ACE-R was compared and receiver operator characteristic curve analysis was undertaken to ascertain the accuracy of the instrument for the diagnosis of mild AD.

RESULTS

The mean scores at the ACE-R were 63.10+/-10.22 points for patients with AD and 83.63+/-7.90 points for controls. The cut-off score <78 yielded high diagnostic accuracy (receiver operator characteristic area under the curve=0.947), with 100% sensitivity, 82.26% specificity, 73.8% positive predictive value, and 100% negative predictive value.

CONCLUSIONS

The Brazilian version of the ACE-R displayed high diagnostic accuracy for the identification of mild AD in the studied sample.

Authors+Show Affiliations

Postgraduate Program in Neurology, University of São Paulo School of Medicine, São Paulo (SP), Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20299857

Citation

Carvalho, Viviane Amaral, et al. "Brazilian Version of the Addenbrooke Cognitive Examination-revised in the Diagnosis of Mild Alzheimer Disease." Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, vol. 23, no. 1, 2010, pp. 8-13.
Carvalho VA, Barbosa MT, Caramelli P. Brazilian version of the Addenbrooke Cognitive Examination-revised in the diagnosis of mild Alzheimer disease. Cogn Behav Neurol. 2010;23(1):8-13.
Carvalho, V. A., Barbosa, M. T., & Caramelli, P. (2010). Brazilian version of the Addenbrooke Cognitive Examination-revised in the diagnosis of mild Alzheimer disease. Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 23(1), 8-13. https://doi.org/10.1097/WNN.0b013e3181c5e2e5
Carvalho VA, Barbosa MT, Caramelli P. Brazilian Version of the Addenbrooke Cognitive Examination-revised in the Diagnosis of Mild Alzheimer Disease. Cogn Behav Neurol. 2010;23(1):8-13. PubMed PMID: 20299857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brazilian version of the Addenbrooke Cognitive Examination-revised in the diagnosis of mild Alzheimer disease. AU - Carvalho,Viviane Amaral, AU - Barbosa,Maira Tonidandel, AU - Caramelli,Paulo, PY - 2010/3/20/entrez PY - 2010/3/20/pubmed PY - 2010/6/24/medline SP - 8 EP - 13 JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology JO - Cogn Behav Neurol VL - 23 IS - 1 N2 - OBJECTIVE: To investigate the accuracy of the Brazilian version of the Addenbrooke Cognitive Examination-revised (ACE-R) in the diagnosis of mild Alzheimer disease (AD). BACKGROUND: The ACE-R is an accurate and brief cognitive battery for the detection of mild dementia, especially for the discrimination between AD and frontotemporal dementia. METHODS: The battery was administered to 31 patients with mild AD and 62 age-matched and education-matched cognitively healthy controls. Both groups were selected using the Dementia Rating Scale and were submitted to the ACE-R. Depression was ruled out in both groups by the Cornell Scale for Depression in Dementia. The performance of patients and controls in the ACE-R was compared and receiver operator characteristic curve analysis was undertaken to ascertain the accuracy of the instrument for the diagnosis of mild AD. RESULTS: The mean scores at the ACE-R were 63.10+/-10.22 points for patients with AD and 83.63+/-7.90 points for controls. The cut-off score <78 yielded high diagnostic accuracy (receiver operator characteristic area under the curve=0.947), with 100% sensitivity, 82.26% specificity, 73.8% positive predictive value, and 100% negative predictive value. CONCLUSIONS: The Brazilian version of the ACE-R displayed high diagnostic accuracy for the identification of mild AD in the studied sample. SN - 1543-3641 UR - https://www.unboundmedicine.com/medline/citation/20299857/Brazilian_version_of_the_Addenbrooke_Cognitive_Examination_revised_in_the_diagnosis_of_mild_Alzheimer_disease_ L2 - https://doi.org/10.1097/WNN.0b013e3181c5e2e5 DB - PRIME DP - Unbound Medicine ER -