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Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.
Obesity (Silver Spring). 2010 Nov; 18(11):2152-9.O

Abstract

The ability of alternate-day fasting (ADF) to modulate adipocyte parameters in a way that is protective against coronary heart disease (CHD) has yet to be tested. Accordingly, we examined the effects of ADF on adipokine profile, body composition, and CHD risk indicators in obese adults. Sixteen obese subjects (12 women/4 men) participated in a 10-week trial with three consecutive dietary intervention phases: (i) 2-week baseline control phase, (ii) 4-week ADF controlled feeding phase, and (iii) 4-week ADF self-selected feeding phase. After 8 weeks of treatment, body weight and waist circumference were reduced (P < 0.05) by 5.7 ± 0.9 kg, and 4.0 ± 0.9 cm, respectively. Fat mass decreased (P < 0.05) by 5.4 ± 0.8 kg, whereas fat-free mass did not change. Plasma adiponectin was augmented (P < 0.05) by 30% from baseline. Leptin and resistin concentrations were reduced (P < 0.05) by 21 and 23%, respectively, post treatment. Low-density lipoprotein cholesterol (LDL-C) and triacylglycerol concentrations were 25% and 32% lower (P < 0.05), respectively, after 8 weeks of ADF. High-density lipoprotein cholesterol (HDL-C), C-reactive protein, and homocysteine concentrations did not change. Decreases in LDL-C were related to increased adiponectin (r = -0.61, P = 0.01) and reduced waist circumference (r = 0.39, P = 0.04). Lower triacylglycerol concentrations were associated with augmented adiponectin (r = -0.39, P = 0.04) and reduced leptin concentrations (r = 0.45, P = 0.03) post-treatment. These findings suggest that adipose tissue parameters may play an important role in mediating the cardioprotective effects of ADF in obese humans.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

20300080

Citation

Bhutani, Surabhi, et al. "Improvements in Coronary Heart Disease Risk Indicators By Alternate-day Fasting Involve Adipose Tissue Modulations." Obesity (Silver Spring, Md.), vol. 18, no. 11, 2010, pp. 2152-9.
Bhutani S, Klempel MC, Berger RA, et al. Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations. Obesity (Silver Spring). 2010;18(11):2152-9.
Bhutani, S., Klempel, M. C., Berger, R. A., & Varady, K. A. (2010). Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations. Obesity (Silver Spring, Md.), 18(11), 2152-9. https://doi.org/10.1038/oby.2010.54
Bhutani S, et al. Improvements in Coronary Heart Disease Risk Indicators By Alternate-day Fasting Involve Adipose Tissue Modulations. Obesity (Silver Spring). 2010;18(11):2152-9. PubMed PMID: 20300080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations. AU - Bhutani,Surabhi, AU - Klempel,Monica C, AU - Berger,Reed A, AU - Varady,Krista A, Y1 - 2010/03/18/ PY - 2010/3/20/entrez PY - 2010/3/20/pubmed PY - 2011/4/16/medline SP - 2152 EP - 9 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 18 IS - 11 N2 - The ability of alternate-day fasting (ADF) to modulate adipocyte parameters in a way that is protective against coronary heart disease (CHD) has yet to be tested. Accordingly, we examined the effects of ADF on adipokine profile, body composition, and CHD risk indicators in obese adults. Sixteen obese subjects (12 women/4 men) participated in a 10-week trial with three consecutive dietary intervention phases: (i) 2-week baseline control phase, (ii) 4-week ADF controlled feeding phase, and (iii) 4-week ADF self-selected feeding phase. After 8 weeks of treatment, body weight and waist circumference were reduced (P < 0.05) by 5.7 ± 0.9 kg, and 4.0 ± 0.9 cm, respectively. Fat mass decreased (P < 0.05) by 5.4 ± 0.8 kg, whereas fat-free mass did not change. Plasma adiponectin was augmented (P < 0.05) by 30% from baseline. Leptin and resistin concentrations were reduced (P < 0.05) by 21 and 23%, respectively, post treatment. Low-density lipoprotein cholesterol (LDL-C) and triacylglycerol concentrations were 25% and 32% lower (P < 0.05), respectively, after 8 weeks of ADF. High-density lipoprotein cholesterol (HDL-C), C-reactive protein, and homocysteine concentrations did not change. Decreases in LDL-C were related to increased adiponectin (r = -0.61, P = 0.01) and reduced waist circumference (r = 0.39, P = 0.04). Lower triacylglycerol concentrations were associated with augmented adiponectin (r = -0.39, P = 0.04) and reduced leptin concentrations (r = 0.45, P = 0.03) post-treatment. These findings suggest that adipose tissue parameters may play an important role in mediating the cardioprotective effects of ADF in obese humans. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/20300080/Improvements_in_coronary_heart_disease_risk_indicators_by_alternate_day_fasting_involve_adipose_tissue_modulations_ L2 - https://doi.org/10.1038/oby.2010.54 DB - PRIME DP - Unbound Medicine ER -