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Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter.
Lab Chip. 2010 Apr 07; 10(7):894-8.LC

Abstract

We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNT-based sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.

Authors+Show Affiliations

Nano-Systems Institute, Seoul National University, Seoul, 151-742, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20300676

Citation

Lee, Byung Yang, et al. "Biosensor System-on-a-chip Including CMOS-based Signal Processing Circuits and 64 Carbon Nanotube-based Sensors for the Detection of a Neurotransmitter." Lab On a Chip, vol. 10, no. 7, 2010, pp. 894-8.
Lee BY, Seo SM, Lee DJ, et al. Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter. Lab Chip. 2010;10(7):894-8.
Lee, B. Y., Seo, S. M., Lee, D. J., Lee, M., Lee, J., Cheon, J. H., Cho, E., Lee, H., Chung, I. Y., Park, Y. J., Kim, S., & Hong, S. (2010). Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter. Lab On a Chip, 10(7), 894-8. https://doi.org/10.1039/b916975j
Lee BY, et al. Biosensor System-on-a-chip Including CMOS-based Signal Processing Circuits and 64 Carbon Nanotube-based Sensors for the Detection of a Neurotransmitter. Lab Chip. 2010 Apr 7;10(7):894-8. PubMed PMID: 20300676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter. AU - Lee,Byung Yang, AU - Seo,Sung Min, AU - Lee,Dong Joon, AU - Lee,Minbaek, AU - Lee,Joohyung, AU - Cheon,Jun-Ho, AU - Cho,Eunju, AU - Lee,Hyunjoong, AU - Chung,In-Young, AU - Park,Young June, AU - Kim,Suhwan, AU - Hong,Seunghun, Y1 - 2010/01/14/ PY - 2010/3/20/entrez PY - 2010/3/20/pubmed PY - 2010/5/7/medline SP - 894 EP - 8 JF - Lab on a chip JO - Lab Chip VL - 10 IS - 7 N2 - We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNT-based sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks. SN - 1473-0197 UR - https://www.unboundmedicine.com/medline/citation/20300676/Biosensor_system_on_a_chip_including_CMOS_based_signal_processing_circuits_and_64_carbon_nanotube_based_sensors_for_the_detection_of_a_neurotransmitter_ L2 - https://doi.org/10.1039/b916975j DB - PRIME DP - Unbound Medicine ER -