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Correlates of symptoms of depression and anxiety in chronic hemodialysis patients.
Gen Hosp Psychiatry. 2010 Mar-Apr; 32(2):125-31.GH

Abstract

OBJECTIVE

Little is known about the demographic, clinical and laboratory variables which may be correlated with symptoms of depression and anxiety in hemodialysis (HD) patients. The present study aimed at evaluating such correlation in HD patients treated at a single HD center in a Mediterranean country.

METHODS

Eighty HD patients were assessed for depression and anxiety with the Beck Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale (HARS). The scores of BDI and HARS were correlated with demographic, clinical and laboratory variables.

RESULTS

Based on the Beck Depression Inventory, 38 patients had no symptoms of depression and 42 had symptoms of depression. Based on the HARS, three patients had no symptoms of anxiety and 38 had mild symptoms of anxiety, whereas moderate or severe symptoms of anxiety were present in 39 patients. In univariate analysis, BDI score correlated significantly with age, the Charlson Comorbidity Index, SF-36 Vitality Subscale, Mini-Mental Status Examination, creatinine, albumin, plasma 25-hydroxy vitamin D and interleukin-6 (IL-6) levels. HARS score correlated significantly with age, Charlson Comorbidity Index, SF-36 Vitality Subscale and parathyroid hormone (PTH) levels. In the multivariate analysis, a direct and an inverse correlation between BDI and IL-6 [P=.042, OR=1.31 (95% CI=1.01-1.71)] and creatinine [P=.050, OR=0.73 (95% CI=0.54-1.00)] was observed. With regard to HARS, only a direct correlation with Charlson Comorbidity Index [P<.001, OR=1.55 (95% CI=1.22-1.96)] was found.

CONCLUSION

Although numerous demographic, clinical and laboratory variables correlated with BDI and HARS in univariate analysis, the multivariate regression analysis showed only a direct correlation between BDI and IL-6 [P=.042, OR=1.31 (95% CI=1.01-1.71)] and an inverse correlation between BDI and creatinine [P=.050, OR=0.73 (95% CI=0.54-1.00)] and a direct correlation between HARS and the Charlson Comorbidity Index [P<.001, OR=1.55 (95% CI=1.22-1.96)].

Authors+Show Affiliations

Servizio Emodialisi, Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, 8-00168 Rome, Italy. maubosso@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20302985

Citation

Bossola, Maurizio, et al. "Correlates of Symptoms of Depression and Anxiety in Chronic Hemodialysis Patients." General Hospital Psychiatry, vol. 32, no. 2, 2010, pp. 125-31.
Bossola M, Ciciarelli C, Di Stasio E, et al. Correlates of symptoms of depression and anxiety in chronic hemodialysis patients. Gen Hosp Psychiatry. 2010;32(2):125-31.
Bossola, M., Ciciarelli, C., Di Stasio, E., Conte, G. L., Vulpio, C., Luciani, G., & Tazza, L. (2010). Correlates of symptoms of depression and anxiety in chronic hemodialysis patients. General Hospital Psychiatry, 32(2), 125-31. https://doi.org/10.1016/j.genhosppsych.2009.10.009
Bossola M, et al. Correlates of Symptoms of Depression and Anxiety in Chronic Hemodialysis Patients. Gen Hosp Psychiatry. 2010 Mar-Apr;32(2):125-31. PubMed PMID: 20302985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlates of symptoms of depression and anxiety in chronic hemodialysis patients. AU - Bossola,Maurizio, AU - Ciciarelli,Claudia, AU - Di Stasio,Enrico, AU - Conte,Gian Luigi, AU - Vulpio,Carlo, AU - Luciani,Giovanna, AU - Tazza,Luigi, Y1 - 2009/12/05/ PY - 2009/06/26/received PY - 2009/10/29/revised PY - 2009/10/30/accepted PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/7/14/medline SP - 125 EP - 31 JF - General hospital psychiatry JO - Gen Hosp Psychiatry VL - 32 IS - 2 N2 - OBJECTIVE: Little is known about the demographic, clinical and laboratory variables which may be correlated with symptoms of depression and anxiety in hemodialysis (HD) patients. The present study aimed at evaluating such correlation in HD patients treated at a single HD center in a Mediterranean country. METHODS: Eighty HD patients were assessed for depression and anxiety with the Beck Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale (HARS). The scores of BDI and HARS were correlated with demographic, clinical and laboratory variables. RESULTS: Based on the Beck Depression Inventory, 38 patients had no symptoms of depression and 42 had symptoms of depression. Based on the HARS, three patients had no symptoms of anxiety and 38 had mild symptoms of anxiety, whereas moderate or severe symptoms of anxiety were present in 39 patients. In univariate analysis, BDI score correlated significantly with age, the Charlson Comorbidity Index, SF-36 Vitality Subscale, Mini-Mental Status Examination, creatinine, albumin, plasma 25-hydroxy vitamin D and interleukin-6 (IL-6) levels. HARS score correlated significantly with age, Charlson Comorbidity Index, SF-36 Vitality Subscale and parathyroid hormone (PTH) levels. In the multivariate analysis, a direct and an inverse correlation between BDI and IL-6 [P=.042, OR=1.31 (95% CI=1.01-1.71)] and creatinine [P=.050, OR=0.73 (95% CI=0.54-1.00)] was observed. With regard to HARS, only a direct correlation with Charlson Comorbidity Index [P<.001, OR=1.55 (95% CI=1.22-1.96)] was found. CONCLUSION: Although numerous demographic, clinical and laboratory variables correlated with BDI and HARS in univariate analysis, the multivariate regression analysis showed only a direct correlation between BDI and IL-6 [P=.042, OR=1.31 (95% CI=1.01-1.71)] and an inverse correlation between BDI and creatinine [P=.050, OR=0.73 (95% CI=0.54-1.00)] and a direct correlation between HARS and the Charlson Comorbidity Index [P<.001, OR=1.55 (95% CI=1.22-1.96)]. SN - 1873-7714 UR - https://www.unboundmedicine.com/medline/citation/20302985/Correlates_of_symptoms_of_depression_and_anxiety_in_chronic_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-8343(09)00229-1 DB - PRIME DP - Unbound Medicine ER -