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Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states.
Int J Lepr Other Mycobact Dis. 1991 Mar; 59(1):20-4.IJ

Abstract

Serum zinc and copper levels and zinc/copper ratios were studied in 86 healthy controls, 45 cases of borderline tuberculoid (BT), 31 cases of borderline lepromatous (BL), 117 cases of lepromatous (LL) leprosy patients, 16 cases with severe erythema nodosum leprosum (ENL) reaction, and 16 cases with ENL reaction receiving oral zinc therapy. A significant reduction in serum zinc levels was noticed in all types of leprosy, the maximum decrease being seen in cases with ENL reaction. Conversely, the copper levels were significantly increased from BT to LL cases with ENL reaction in a progressive manner. A very good negative correlation (r = -0.998) was noticed between mean serum zinc and copper levels from healthy controls to active LL cases with ENL reaction. After oral zinc therapy, the serum zinc levels were significantly increased in all of the 16 LL patients with ENL reaction. In contrast, the copper levels were not decreased, indicating that oral zinc therapy can restore normal zinc levels in leprosy patients but is unable to reduce the increased copper levels.

Authors+Show Affiliations

Department of Biochemistry, Central Leprosy Teaching and Research Institute, Chengalpattu, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2030313

Citation

George, J, et al. "Serum Zinc/copper Ratio in Subtypes of Leprosy and Effect of Oral Zinc Therapy On Reactional States." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 59, no. 1, 1991, pp. 20-4.
George J, Bhatia VN, Balakrishnan S, et al. Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. Int J Lepr Other Mycobact Dis. 1991;59(1):20-4.
George, J., Bhatia, V. N., Balakrishnan, S., & Ramu, G. (1991). Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 59(1), 20-4.
George J, et al. Serum Zinc/copper Ratio in Subtypes of Leprosy and Effect of Oral Zinc Therapy On Reactional States. Int J Lepr Other Mycobact Dis. 1991;59(1):20-4. PubMed PMID: 2030313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. AU - George,J, AU - Bhatia,V N, AU - Balakrishnan,S, AU - Ramu,G, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 20 EP - 4 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 59 IS - 1 N2 - Serum zinc and copper levels and zinc/copper ratios were studied in 86 healthy controls, 45 cases of borderline tuberculoid (BT), 31 cases of borderline lepromatous (BL), 117 cases of lepromatous (LL) leprosy patients, 16 cases with severe erythema nodosum leprosum (ENL) reaction, and 16 cases with ENL reaction receiving oral zinc therapy. A significant reduction in serum zinc levels was noticed in all types of leprosy, the maximum decrease being seen in cases with ENL reaction. Conversely, the copper levels were significantly increased from BT to LL cases with ENL reaction in a progressive manner. A very good negative correlation (r = -0.998) was noticed between mean serum zinc and copper levels from healthy controls to active LL cases with ENL reaction. After oral zinc therapy, the serum zinc levels were significantly increased in all of the 16 LL patients with ENL reaction. In contrast, the copper levels were not decreased, indicating that oral zinc therapy can restore normal zinc levels in leprosy patients but is unable to reduce the increased copper levels. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2030313/Serum_zinc/copper_ratio_in_subtypes_of_leprosy_and_effect_of_oral_zinc_therapy_on_reactional_states_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -