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Beneficial effect of pine honey on trichlorfon induced some biochemical alterations in mice.

Abstract

Forty-eight male BALB/c mice, weighing 30-35 g, were used in the study, and were divided into groups of 12 each. The four groups established in the study included one control group and three experimental groups. The first group served as the control group, while Groups 2, 3 and 4 were administered 1g/kg bw/day pine honey, 180 mg/kg bw/day trichlorfon ( approximately 1/5LD(50)) and 1g/kg bw/day pine honey plus 180 mg/kg bw/day trichlorfon, respectively, by the oral route using a catheter for 21 days. At the end of 21 days post-administration, blood and tissue (liver, kidney, brain and heart) samples were collected. Serum levels/activities of total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT and ALP were determined. Furthermore, tissue MDA levels and CAT, SOD and GSH-Px activities were analyzed. According to the data obtained, when administered at the indicated dose and for the indicated time period, trichlorfon was determined to lead to negative alterations in most of the biochemical parameters investigated. The administration of pine honey was determined to alleviate this effect.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, University of Erciyes, Kayseri, Turkey. geraslan38@hotmail.com

    , ,

    Source

    MeSH

    Animals
    Biological Markers
    Biological Products
    Honey
    Insecticides
    Male
    Mice
    Mice, Inbred BALB C
    Oxidative Stress
    Trichlorfon

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20303175

    Citation

    TY - JOUR T1 - Beneficial effect of pine honey on trichlorfon induced some biochemical alterations in mice. AU - Eraslan,Gökhan, AU - Kanbur,Murat, AU - Silici,Sibel, AU - Karabacak,Mürsel, Y1 - 2010/03/29/ PY - 2008/10/3/received PY - 2009/9/29/revised PY - 2010/2/22/accepted PY - 2010/3/29/aheadofprint PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/12/14/medline SP - 1084 EP - 91 JF - Ecotoxicology and environmental safety JO - Ecotoxicol. Environ. Saf. VL - 73 IS - 5 N2 - Forty-eight male BALB/c mice, weighing 30-35 g, were used in the study, and were divided into groups of 12 each. The four groups established in the study included one control group and three experimental groups. The first group served as the control group, while Groups 2, 3 and 4 were administered 1g/kg bw/day pine honey, 180 mg/kg bw/day trichlorfon ( approximately 1/5LD(50)) and 1g/kg bw/day pine honey plus 180 mg/kg bw/day trichlorfon, respectively, by the oral route using a catheter for 21 days. At the end of 21 days post-administration, blood and tissue (liver, kidney, brain and heart) samples were collected. Serum levels/activities of total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT and ALP were determined. Furthermore, tissue MDA levels and CAT, SOD and GSH-Px activities were analyzed. According to the data obtained, when administered at the indicated dose and for the indicated time period, trichlorfon was determined to lead to negative alterations in most of the biochemical parameters investigated. The administration of pine honey was determined to alleviate this effect. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/20303175/full_citation/Beneficial_effect_of_pine_honey_on_trichlorfon_induced_some_biochemical_alterations_in_mice_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0147-6513(10)00049-7 ER -