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Genetic variation analysis of 15 autosomal STR loci of AmpFlSTR Sinofiler PCR Amplification Kit in Henan (central China) Han population.
Leg Med (Tokyo). 2010 May; 12(3):160-1.LM

Abstract

AmpFlSTR Sinofiler PCR Amplification Kit is specially developed for Chinese forensic laboratories, but there are little population-genetic indices about this kit as a whole. This kit contains 15 STR loci: D8S1179, D21S11, D7S820, CSF1PO, D3S1358, D13S317, D16S539, D2S1338, D19S433, vWA, D18S51, D6S1043, D12S391, D5S818 and FGA. In order to evaluate this kit and to get basic population-genetic indices for its use in forensic practice in Chinese Han population, the DNA of 231 unrelated Han individuals from Henan (central China) were typed using the Kit. The most discriminating locus was D6S1043 while the least was D3S1358. The combined match probability was 9.81x10(-19) and the combined power of exclusion was 0.99999974. Statistical analysis of the generated data indicated no departure from expectation of Hardy-Weinberg Equilibrium (HWE) in all loci but D6S1043 and no linkage disequilibrium in all pairs of loci. The observed and expected heterozygosity, power of discrimination, polymorphic information content, the other population-genetic indices were calculated.

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Authors+Show Affiliations

Huang S
Department of Forensic Medicine, College of Basic Science of Medicine, Zhengzhou University, Zhengzhou, Henan Province 450052, PR China.
Zhu Y
No affiliation info available
Shen X
No affiliation info available
Le X
No affiliation info available
Yan H
No affiliation info available

MeSH

ChinaDNA FingerprintingEthnic GroupsGene FrequencyGenetic VariationGenetics, PopulationHumansPolymerase Chain ReactionTandem Repeat Sequences

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20303817

Citation

Huang, Shuqin, et al. "Genetic Variation Analysis of 15 Autosomal STR Loci of AmpFlSTR Sinofiler PCR Amplification Kit in Henan (central China) Han Population." Legal Medicine (Tokyo, Japan), vol. 12, no. 3, 2010, pp. 160-1.
Huang S, Zhu Y, Shen X, et al. Genetic variation analysis of 15 autosomal STR loci of AmpFlSTR Sinofiler PCR Amplification Kit in Henan (central China) Han population. Leg Med (Tokyo). 2010;12(3):160-1.
Huang, S., Zhu, Y., Shen, X., Le, X., & Yan, H. (2010). Genetic variation analysis of 15 autosomal STR loci of AmpFlSTR Sinofiler PCR Amplification Kit in Henan (central China) Han population. Legal Medicine (Tokyo, Japan), 12(3), 160-1. https://doi.org/10.1016/j.legalmed.2010.02.004
Huang S, et al. Genetic Variation Analysis of 15 Autosomal STR Loci of AmpFlSTR Sinofiler PCR Amplification Kit in Henan (central China) Han Population. Leg Med (Tokyo). 2010;12(3):160-1. PubMed PMID: 20303817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic variation analysis of 15 autosomal STR loci of AmpFlSTR Sinofiler PCR Amplification Kit in Henan (central China) Han population. AU - Huang,Shuqin, AU - Zhu,Yunliang, AU - Shen,Xintang, AU - Le,Xiaoping, AU - Yan,Hongtao, Y1 - 2010/03/19/ PY - 2010/01/14/received PY - 2010/02/16/accepted PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/7/16/medline SP - 160 EP - 1 JF - Legal medicine (Tokyo, Japan) JO - Leg Med (Tokyo) VL - 12 IS - 3 N2 - AmpFlSTR Sinofiler PCR Amplification Kit is specially developed for Chinese forensic laboratories, but there are little population-genetic indices about this kit as a whole. This kit contains 15 STR loci: D8S1179, D21S11, D7S820, CSF1PO, D3S1358, D13S317, D16S539, D2S1338, D19S433, vWA, D18S51, D6S1043, D12S391, D5S818 and FGA. In order to evaluate this kit and to get basic population-genetic indices for its use in forensic practice in Chinese Han population, the DNA of 231 unrelated Han individuals from Henan (central China) were typed using the Kit. The most discriminating locus was D6S1043 while the least was D3S1358. The combined match probability was 9.81x10(-19) and the combined power of exclusion was 0.99999974. Statistical analysis of the generated data indicated no departure from expectation of Hardy-Weinberg Equilibrium (HWE) in all loci but D6S1043 and no linkage disequilibrium in all pairs of loci. The observed and expected heterozygosity, power of discrimination, polymorphic information content, the other population-genetic indices were calculated. SN - 1873-4162 UR - https://www.unboundmedicine.com/medline/citation/20303817/Genetic_variation_analysis_of_15_autosomal_STR_loci_of_AmpFlSTR_Sinofiler_PCR_Amplification_Kit_in_Henan__central_China__Han_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1344-6223(10)00033-7 DB - PRIME DP - Unbound Medicine ER -