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Auditory and visual P300 reflecting cognitive improvement in patients with schizophrenia with quetiapine: a pilot study.

Abstract

We recorded event-related potentials (ERPs) in patients with schizophrenia before and after treatment with quetiapine, to investigate this drug's effects on cognitive function. Auditory and visual oddball stimulus discrimination paradigms were presented to patients with schizophrenia (N=20) before and after 3months' treatment with quetiapine. The 2-stimulus auditory oddball paradigm used a standard tone (1000Hz, 75dB, 80%) and a target tone (2000Hz, 75dB, 20%). The 2-stimulus visual oddball paradigm used a standard stimulus (small circle, 80%) and a target stimulus (large circle, 20%). Patients' severity of psychopathology was initially evaluated with the Positive and Negative Syndrome Scale (PANSS) and was likewise re-evaluated after treatment. After treatment with quetiapine, patients' P300 amplitudes increased over baseline for both tasks (auditory stimuli, P<0.01; visual stimuli, P<0.01) and their P300 latencies for both target stimuli decreased significantly (auditory stimuli, P<0.001; visual stimuli, P<0.01). Visual P300 amplitude was negatively correlated with the severity of positive symptoms at the Fz electrode before the treatment (r=-0.45, P<0.05). After treatment with quetiapine, there were no significant correlations between severity of positive or negative symptoms and visual P300 amplitudes for midline electrodes. These findings suggest that the reduced and delayed P300 may be a state marker for schizophrenia, which may in turn be modulated by positive symptoms, and also suggest that the amplitude and latency for both auditory and visual tasks may be decreased by quetiapine treatment. Based on these results, we suggest that the atypical antipsychotic quetiapine may improve some aspects of cognitive domains in patients with schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Incheon St. Mary's Hospital, The Catholic University of Korea, #665, Bupyeongdong, Bupyeonggu, Incheon, 403-720, Republic of Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20304022

Citation

Park, E-Jin, et al. "Auditory and Visual P300 Reflecting Cognitive Improvement in Patients With Schizophrenia With Quetiapine: a Pilot Study." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 4, 2010, pp. 674-80.
Park EJ, Han SI, Jeon YW. Auditory and visual P300 reflecting cognitive improvement in patients with schizophrenia with quetiapine: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(4):674-80.
Park, E. J., Han, S. I., & Jeon, Y. W. (2010). Auditory and visual P300 reflecting cognitive improvement in patients with schizophrenia with quetiapine: a pilot study. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(4), pp. 674-80. doi:10.1016/j.pnpbp.2010.03.011.
Park EJ, Han SI, Jeon YW. Auditory and Visual P300 Reflecting Cognitive Improvement in Patients With Schizophrenia With Quetiapine: a Pilot Study. Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):674-80. PubMed PMID: 20304022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Auditory and visual P300 reflecting cognitive improvement in patients with schizophrenia with quetiapine: a pilot study. AU - Park,E-Jin, AU - Han,Sang-Ick, AU - Jeon,Yang-Whan, Y1 - 2010/03/19/ PY - 2009/11/03/received PY - 2010/03/08/revised PY - 2010/03/08/accepted PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/7/31/medline SP - 674 EP - 80 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 4 N2 - We recorded event-related potentials (ERPs) in patients with schizophrenia before and after treatment with quetiapine, to investigate this drug's effects on cognitive function. Auditory and visual oddball stimulus discrimination paradigms were presented to patients with schizophrenia (N=20) before and after 3months' treatment with quetiapine. The 2-stimulus auditory oddball paradigm used a standard tone (1000Hz, 75dB, 80%) and a target tone (2000Hz, 75dB, 20%). The 2-stimulus visual oddball paradigm used a standard stimulus (small circle, 80%) and a target stimulus (large circle, 20%). Patients' severity of psychopathology was initially evaluated with the Positive and Negative Syndrome Scale (PANSS) and was likewise re-evaluated after treatment. After treatment with quetiapine, patients' P300 amplitudes increased over baseline for both tasks (auditory stimuli, P<0.01; visual stimuli, P<0.01) and their P300 latencies for both target stimuli decreased significantly (auditory stimuli, P<0.001; visual stimuli, P<0.01). Visual P300 amplitude was negatively correlated with the severity of positive symptoms at the Fz electrode before the treatment (r=-0.45, P<0.05). After treatment with quetiapine, there were no significant correlations between severity of positive or negative symptoms and visual P300 amplitudes for midline electrodes. These findings suggest that the reduced and delayed P300 may be a state marker for schizophrenia, which may in turn be modulated by positive symptoms, and also suggest that the amplitude and latency for both auditory and visual tasks may be decreased by quetiapine treatment. Based on these results, we suggest that the atypical antipsychotic quetiapine may improve some aspects of cognitive domains in patients with schizophrenia. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20304022/Auditory_and_visual_P300_reflecting_cognitive_improvement_in_patients_with_schizophrenia_with_quetiapine:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00087-4 DB - PRIME DP - Unbound Medicine ER -