Tags

Type your tag names separated by a space and hit enter

Critical analysis of deaths due to atypical pneumonia during the onset of the influenza A (H1N1) virus epidemic.
Arch Med Res. 2009 Nov; 40(8):662-8.AM

Abstract

BACKGROUND

The ongoing influenza A (H1N1) pandemic stroked Mexico and posed a huge challenge to the medical care and public health systems. This report analyzes the clinical course and process of care of patients who died due to atypical pneumonia and fulfilled the clinical criteria of suspected case of novel influenza A (H1N1) virus infection.

METHODS

We conducted a retrospective analysis of a series of 38 patients who died between April 7 and April 28, 2009 at Instituto Mexicano del Seguro Social (IMSS) hospitals due to severe pneumonia and respiratory distress. These cases coincided with the beginning of the outbreak, so patients did not undergo laboratory testing to diagnose influenza. According to IMSS and CDC criteria, post-hoc analysis allowed considering the presumptive diagnosis of S-OIV infection. A multidisciplinary group analyzed the information from the clinical charts, laboratory tests, radiographic studies and death certificates, using descriptive statistics.

RESULTS

Most cases were middle-aged (mean 33 years, range: 4-62 years) and previously healthy; 18.4% had an underlying chronic disease, 23.7% were obese and 7.9% were current smokers. None had received the seasonal influenza vaccine; they had cough (92%), fever (86.8%), and malaise (73.7%). The median time from disease onset to hospital admission was 6 days (range 0-8 days). All were admitted to the intensive care unit with pneumonia and/or respiratory distress. Average time from disease onset to death was 8 days (range 4-18 days).

CONCLUSIONS

An increased number of severe cases of atypical pneumonia in previously healthy adults highlight the importance of the availability of a timely surveillance system able to identify sudden increases in the number of cases or presentation of apparently known diseases.

Authors+Show Affiliations

Coordinación de Investigación en Salud, Hospital Carlos McGregor, IMSS, Mexico, D.F., Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20304253

Citation

Grijalva-Otero, Israel, et al. "Critical Analysis of Deaths Due to Atypical Pneumonia During the Onset of the Influenza a (H1N1) Virus Epidemic." Archives of Medical Research, vol. 40, no. 8, 2009, pp. 662-8.
Grijalva-Otero I, Talavera JO, Solorzano-Santos F, et al. Critical analysis of deaths due to atypical pneumonia during the onset of the influenza A (H1N1) virus epidemic. Arch Med Res. 2009;40(8):662-8.
Grijalva-Otero, I., Talavera, J. O., Solorzano-Santos, F., Vazquez-Rosales, G., Vladislavovna-Doubova, S., Pérez-Cuevas, R., Miranda-Novales, G., García-Peña, C., Espinel-Bermúdez, C., Torres, J., & de la Peña, J. E. (2009). Critical analysis of deaths due to atypical pneumonia during the onset of the influenza A (H1N1) virus epidemic. Archives of Medical Research, 40(8), 662-8. https://doi.org/10.1016/j.arcmed.2009.10.010
Grijalva-Otero I, et al. Critical Analysis of Deaths Due to Atypical Pneumonia During the Onset of the Influenza a (H1N1) Virus Epidemic. Arch Med Res. 2009;40(8):662-8. PubMed PMID: 20304253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Critical analysis of deaths due to atypical pneumonia during the onset of the influenza A (H1N1) virus epidemic. AU - Grijalva-Otero,Israel, AU - Talavera,Juan Osvaldo, AU - Solorzano-Santos,Fortino, AU - Vazquez-Rosales,Guillermo, AU - Vladislavovna-Doubova,Svetlana, AU - Pérez-Cuevas,Ricardo, AU - Miranda-Novales,Guadalupe, AU - García-Peña,Carmen, AU - Espinel-Bermúdez,Claudia, AU - Torres,Javier, AU - de la Peña,Jorge Escobedo, Y1 - 2010/01/06/ PY - 2009/10/06/received PY - 2009/10/13/accepted PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/6/11/medline SP - 662 EP - 8 JF - Archives of medical research JO - Arch. Med. Res. VL - 40 IS - 8 N2 - BACKGROUND: The ongoing influenza A (H1N1) pandemic stroked Mexico and posed a huge challenge to the medical care and public health systems. This report analyzes the clinical course and process of care of patients who died due to atypical pneumonia and fulfilled the clinical criteria of suspected case of novel influenza A (H1N1) virus infection. METHODS: We conducted a retrospective analysis of a series of 38 patients who died between April 7 and April 28, 2009 at Instituto Mexicano del Seguro Social (IMSS) hospitals due to severe pneumonia and respiratory distress. These cases coincided with the beginning of the outbreak, so patients did not undergo laboratory testing to diagnose influenza. According to IMSS and CDC criteria, post-hoc analysis allowed considering the presumptive diagnosis of S-OIV infection. A multidisciplinary group analyzed the information from the clinical charts, laboratory tests, radiographic studies and death certificates, using descriptive statistics. RESULTS: Most cases were middle-aged (mean 33 years, range: 4-62 years) and previously healthy; 18.4% had an underlying chronic disease, 23.7% were obese and 7.9% were current smokers. None had received the seasonal influenza vaccine; they had cough (92%), fever (86.8%), and malaise (73.7%). The median time from disease onset to hospital admission was 6 days (range 0-8 days). All were admitted to the intensive care unit with pneumonia and/or respiratory distress. Average time from disease onset to death was 8 days (range 4-18 days). CONCLUSIONS: An increased number of severe cases of atypical pneumonia in previously healthy adults highlight the importance of the availability of a timely surveillance system able to identify sudden increases in the number of cases or presentation of apparently known diseases. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/20304253/Critical_analysis_of_deaths_due_to_atypical_pneumonia_during_the_onset_of_the_influenza_A__H1N1__virus_epidemic_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(09)00199-4 DB - PRIME DP - Unbound Medicine ER -