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Do early-life viral infections cause asthma?
J Allergy Clin Immunol. 2010 Jun; 125(6):1202-5.JA

Abstract

Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known. However, the question of whether such infections cause asthma or unmask asthma in a susceptible host has still not been settled. Most early evidence centered on the role of the respiratory syncytial virus; however, recent studies highlight a potential role for human rhinovirus as a risk factor for asthma. The links between early-life viral LRI and subsequent asthma are generally via wheeze; however, the presence of wheeze does not give any information about why the child is wheezing. Wheeze in early life is, at best, a fuzzy phenotype and not specific for subsequent asthma. The risk of asthma after viral LRI is increased in the presence of allergic sensitization in early life and if the infection is more severe. Atopy-associated mechanisms also appear to be involved in viral-induced acute exacerbations of asthma, especially in prolonging symptomatology after the virus has been cleared from the lungs. Breaking the nexus between viral respiratory infections and asthma may be possible with interventions designed to inhibit atopy-related effectors mechanisms from participating in the host response to respiratory viral infections.

Authors+Show Affiliations

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia. peters@ichr.uwa.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20304476

Citation

Sly, Peter D., et al. "Do Early-life Viral Infections Cause Asthma?" The Journal of Allergy and Clinical Immunology, vol. 125, no. 6, 2010, pp. 1202-5.
Sly PD, Kusel M, Holt PG. Do early-life viral infections cause asthma? J Allergy Clin Immunol. 2010;125(6):1202-5.
Sly, P. D., Kusel, M., & Holt, P. G. (2010). Do early-life viral infections cause asthma? The Journal of Allergy and Clinical Immunology, 125(6), 1202-5. https://doi.org/10.1016/j.jaci.2010.01.024
Sly PD, Kusel M, Holt PG. Do Early-life Viral Infections Cause Asthma. J Allergy Clin Immunol. 2010;125(6):1202-5. PubMed PMID: 20304476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do early-life viral infections cause asthma? AU - Sly,Peter D, AU - Kusel,Merci, AU - Holt,Patrick G, Y1 - 2010/03/20/ PY - 2009/12/02/received PY - 2010/01/13/revised PY - 2010/01/13/accepted PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/8/25/medline SP - 1202 EP - 5 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 125 IS - 6 N2 - Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known. However, the question of whether such infections cause asthma or unmask asthma in a susceptible host has still not been settled. Most early evidence centered on the role of the respiratory syncytial virus; however, recent studies highlight a potential role for human rhinovirus as a risk factor for asthma. The links between early-life viral LRI and subsequent asthma are generally via wheeze; however, the presence of wheeze does not give any information about why the child is wheezing. Wheeze in early life is, at best, a fuzzy phenotype and not specific for subsequent asthma. The risk of asthma after viral LRI is increased in the presence of allergic sensitization in early life and if the infection is more severe. Atopy-associated mechanisms also appear to be involved in viral-induced acute exacerbations of asthma, especially in prolonging symptomatology after the virus has been cleared from the lungs. Breaking the nexus between viral respiratory infections and asthma may be possible with interventions designed to inhibit atopy-related effectors mechanisms from participating in the host response to respiratory viral infections. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/20304476/Do_early_life_viral_infections_cause_asthma L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(10)00118-1 DB - PRIME DP - Unbound Medicine ER -