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Role of rhinovirus C respiratory infections in sick and healthy children in Spain.
Pediatr Infect Dis J. 2010 Aug; 29(8):717-20.PI

Abstract

BACKGROUND

Recently a new genogroup of human rhinovirus (HRV) has been described and named HRV-C. The relative importance of HRV-C in viral respiratory tract illnesses is unknown.

OBJECTIVE

We looked for HRV-C in pediatric patients with respiratory tract infections to determine the incidence of HRV-C and its role in sick and healthy children. We describe the clinical differences associated with HRV-C infections and other HRV genogroups.

PATIENTS AND METHODS

From January 2004 to December 2008, a prospective study was conducted in children younger than 14 years who were admitted with respiratory infection to the Pediatrics Department of the Severo Ochoa Hospital in Madrid, Spain. Specimens of nasopharyngeal aspirate were taken for virologic study with polymerase chain reaction, and clinical data were recorded. HRV specimens were genotyped. We studied the frequency of HRV-C infections, the clinical course of these patients and the differences with other HRV genogroups (HRV-A and HRV-B). Presence of HRV-C was also studied in a group of healthy children.

RESULTS

HRV was detected in 424 of 1555 episodes of illness (27.2%) and in 26 of 211 healthy children (12.3%) (P < 0.001). We amplified at random 248 of them (227 hospitalized children and 21 healthy children): 132 (53.2%) had HRV-A, 28 (11.2%) had HRV-B, and 88 (35.4%) HRV-C. HRV-C infections were associated with asthma, recurrent wheezing, and bronchiolitis but were not significantly different from the HRV-A genogroup. Nevertheless, significant clinical differences were observed between the HRV-B genogroup and the other groups: more frequent infiltrate on chest radiograph (P = 0.017), fever (P = 0.052), diagnosis of pneumonia (P = 0.01), and antibiotic treatment (P = 0.004).

CONCLUSIONS

HRV-C infections were frequent in hospitalized children with respiratory diseases and were associated with asthma, recurrent wheezing, and bronchiolitis. No clinical differences were found with the HRV-A group: HRV-B group had clinical differences with both the other groups.

Authors+Show Affiliations

Department of Pediatrics, Hospital Severo Ochoa, Leganés, Madrid, Spain. ccalvorey@ono.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20305581

Citation

Calvo, Cristina, et al. "Role of Rhinovirus C Respiratory Infections in Sick and Healthy Children in Spain." The Pediatric Infectious Disease Journal, vol. 29, no. 8, 2010, pp. 717-20.
Calvo C, Casas I, García-García ML, et al. Role of rhinovirus C respiratory infections in sick and healthy children in Spain. Pediatr Infect Dis J. 2010;29(8):717-20.
Calvo, C., Casas, I., García-García, M. L., Pozo, F., Reyes, N., Cruz, N., García-Cuenllas, L., & Pérez-Breña, P. (2010). Role of rhinovirus C respiratory infections in sick and healthy children in Spain. The Pediatric Infectious Disease Journal, 29(8), 717-20. https://doi.org/10.1097/INF.0b013e3181d7a708
Calvo C, et al. Role of Rhinovirus C Respiratory Infections in Sick and Healthy Children in Spain. Pediatr Infect Dis J. 2010;29(8):717-20. PubMed PMID: 20305581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of rhinovirus C respiratory infections in sick and healthy children in Spain. AU - Calvo,Cristina, AU - Casas,Inmaculada, AU - García-García,Maria Luz, AU - Pozo,Francisco, AU - Reyes,Noelia, AU - Cruz,Nieves, AU - García-Cuenllas,Luisa, AU - Pérez-Breña,Pilar, PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2010/11/5/medline SP - 717 EP - 20 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 29 IS - 8 N2 - BACKGROUND: Recently a new genogroup of human rhinovirus (HRV) has been described and named HRV-C. The relative importance of HRV-C in viral respiratory tract illnesses is unknown. OBJECTIVE: We looked for HRV-C in pediatric patients with respiratory tract infections to determine the incidence of HRV-C and its role in sick and healthy children. We describe the clinical differences associated with HRV-C infections and other HRV genogroups. PATIENTS AND METHODS: From January 2004 to December 2008, a prospective study was conducted in children younger than 14 years who were admitted with respiratory infection to the Pediatrics Department of the Severo Ochoa Hospital in Madrid, Spain. Specimens of nasopharyngeal aspirate were taken for virologic study with polymerase chain reaction, and clinical data were recorded. HRV specimens were genotyped. We studied the frequency of HRV-C infections, the clinical course of these patients and the differences with other HRV genogroups (HRV-A and HRV-B). Presence of HRV-C was also studied in a group of healthy children. RESULTS: HRV was detected in 424 of 1555 episodes of illness (27.2%) and in 26 of 211 healthy children (12.3%) (P < 0.001). We amplified at random 248 of them (227 hospitalized children and 21 healthy children): 132 (53.2%) had HRV-A, 28 (11.2%) had HRV-B, and 88 (35.4%) HRV-C. HRV-C infections were associated with asthma, recurrent wheezing, and bronchiolitis but were not significantly different from the HRV-A genogroup. Nevertheless, significant clinical differences were observed between the HRV-B genogroup and the other groups: more frequent infiltrate on chest radiograph (P = 0.017), fever (P = 0.052), diagnosis of pneumonia (P = 0.01), and antibiotic treatment (P = 0.004). CONCLUSIONS: HRV-C infections were frequent in hospitalized children with respiratory diseases and were associated with asthma, recurrent wheezing, and bronchiolitis. No clinical differences were found with the HRV-A group: HRV-B group had clinical differences with both the other groups. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/20305581/Role_of_rhinovirus_C_respiratory_infections_in_sick_and_healthy_children_in_Spain_ L2 - https://doi.org/10.1097/INF.0b013e3181d7a708 DB - PRIME DP - Unbound Medicine ER -