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Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women.
Osteoporos Int 2011; 22(1):113-9OI

Abstract

Fat mass (FM) is closely related to bone mineral density (BMD). However, the associations of FM and fat distribution with BMD in pre- and postmenopausal women are still poorly understood. The present study showed android fat mass accumulation after menopause had a negative association with BMD.

INTRODUCTION

FM is closely related to BMD. However, it is unknown whether FM and central fat distribution have different associations with BMD in pre- and postmenopausal women. The study aims to investigate the associations of FM and fat distribution with BMD in pre- and postmenopausal Chinese women.

METHODS

Two hundred sixty premenopausal and 267 postmenopausal women aged 18 to 79 years were analyzed. Lean mass (LM), FM, percent body fat (%BF), android FM, gynoid FM, and total and regional BMD were measured using dual-energy X-ray absorptiometry. Fat distribution was assessed by android to gynoid FM ratio (AOI). Multiple regression analysis was performed to examine the associations of BMD with FM, LM, and AOI.

RESULTS

FM, %BF, android FM, and AOI were significantly higher, whereas total and regional BMD were significantly lower in postmenopausal women (all р < 0.01). In premenopausal women, FM was positively associated with total and regional BMD (all р < 0.05). AOI had no significant association with BMD. In postmenopausal women, FM was significantly associated with total and regional BMD even additionally adjusting for LM (all р < 0.01). AOI had significantly negative association with total, head, arm, and leg BMD (all р < 0.05). The results remained unchanged when replacing FM with %BF.

CONCLUSIONS

There were different associations of FM and fat distribution with BMD in pre- and postmenopausal Chinese women. Increased central body fat had a negative association with BMD. Our findings may have significant implications in the prevention of menopause-related osteoporosis through reducing centralized fat deposition.

Authors+Show Affiliations

Obesity and Body Composition Research Center, School of Public Health, Zhejiang University, 388 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20306018

Citation

Fu, X, et al. "Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Pre- and Postmenopausal Chinese Women." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 22, no. 1, 2011, pp. 113-9.
Fu X, Ma X, Lu H, et al. Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women. Osteoporos Int. 2011;22(1):113-9.
Fu, X., Ma, X., Lu, H., He, W., Wang, Z., & Zhu, S. (2011). Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 22(1), pp. 113-9. doi:10.1007/s00198-010-1210-9.
Fu X, et al. Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Pre- and Postmenopausal Chinese Women. Osteoporos Int. 2011;22(1):113-9. PubMed PMID: 20306018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women. AU - Fu,X, AU - Ma,X, AU - Lu,H, AU - He,W, AU - Wang,Z, AU - Zhu,S, Y1 - 2010/03/20/ PY - 2009/12/17/received PY - 2010/01/27/accepted PY - 2010/3/23/entrez PY - 2010/3/23/pubmed PY - 2011/8/31/medline SP - 113 EP - 9 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 22 IS - 1 N2 - UNLABELLED: Fat mass (FM) is closely related to bone mineral density (BMD). However, the associations of FM and fat distribution with BMD in pre- and postmenopausal women are still poorly understood. The present study showed android fat mass accumulation after menopause had a negative association with BMD. INTRODUCTION: FM is closely related to BMD. However, it is unknown whether FM and central fat distribution have different associations with BMD in pre- and postmenopausal women. The study aims to investigate the associations of FM and fat distribution with BMD in pre- and postmenopausal Chinese women. METHODS: Two hundred sixty premenopausal and 267 postmenopausal women aged 18 to 79 years were analyzed. Lean mass (LM), FM, percent body fat (%BF), android FM, gynoid FM, and total and regional BMD were measured using dual-energy X-ray absorptiometry. Fat distribution was assessed by android to gynoid FM ratio (AOI). Multiple regression analysis was performed to examine the associations of BMD with FM, LM, and AOI. RESULTS: FM, %BF, android FM, and AOI were significantly higher, whereas total and regional BMD were significantly lower in postmenopausal women (all р < 0.01). In premenopausal women, FM was positively associated with total and regional BMD (all р < 0.05). AOI had no significant association with BMD. In postmenopausal women, FM was significantly associated with total and regional BMD even additionally adjusting for LM (all р < 0.01). AOI had significantly negative association with total, head, arm, and leg BMD (all р < 0.05). The results remained unchanged when replacing FM with %BF. CONCLUSIONS: There were different associations of FM and fat distribution with BMD in pre- and postmenopausal Chinese women. Increased central body fat had a negative association with BMD. Our findings may have significant implications in the prevention of menopause-related osteoporosis through reducing centralized fat deposition. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/20306018/Associations_of_fat_mass_and_fat_distribution_with_bone_mineral_density_in_pre__and_postmenopausal_Chinese_women_ L2 - https://dx.doi.org/10.1007/s00198-010-1210-9 DB - PRIME DP - Unbound Medicine ER -