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Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of bis selenide in the mouse tail suspension test.
Eur J Pharmacol. 2010 Jun 10; 635(1-3):135-41.EJ

Abstract

The present study investigated a possible antidepressant-like effect of bis selenide by using the forced swimming and the tail suspension tests. The involvement of the l-arginine-nitric oxide-cyclic guanosine monophosphate signaling pathway in the antidepressant-like action of bis selenide was investigated. Bis selenide, given by oral route at doses of 0.5-5mg/kg, decreased the immobility time in the forced swimming and tail suspension tests. Pretreatment with l-arginine (750mg/kg, intraperitoneal, i.p., a nitric oxide precursor), sildenafil (5mg/kg, i.p., a phosphodiesterase 5 inhibitor) or S-nitroso-N-acetyl-penicillamine (25microg/site, intracerebroventricular, i.c.v., a nitric oxide donor) reversed the reduction in the immobility time elicited by bis selenide (1mg/kg, p.o.) in the tail suspension test. Bis selenide (0.1mg/kg, p.o., a subeffective dose) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine (0.3mg/kg, i.p., an inhibitor of nitric oxide synthase) or 7-nitroindazole (25mg/kg, i.p., a specific neuronal nitric oxide synthase inhibitor) in the tail suspension test. Pretreatment of animals with methylene blue (10mg/kg, i.p., an inhibitor of nitric oxide synthase and soluble guanylate cyclase) or 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one (30pmol, i.c.v., a specific inhibitor of soluble guanylate cyclase), at subeffective doses, caused a synergistic effect with bis selenide in the tail suspension test. Bis selenide (1mg/kg, p.o.), at an effective dose in the forced swimming and tail suspension tests, caused a significant decrease in the mouse cerebral nitrate/nitrite levels. The antidepressant-like effect of bis selenide in the tail suspension test is dependent on the inhibition of the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway.

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20307533

Citation

Jesse, Cristiano R., et al. "Involvement of L-arginine-nitric Oxide-cyclic Guanosine Monophosphate Pathway in the Antidepressant-like Effect of Bis Selenide in the Mouse Tail Suspension Test." European Journal of Pharmacology, vol. 635, no. 1-3, 2010, pp. 135-41.
Jesse CR, Wilhelm EA, Bortolatto CF, et al. Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of bis selenide in the mouse tail suspension test. Eur J Pharmacol. 2010;635(1-3):135-41.
Jesse, C. R., Wilhelm, E. A., Bortolatto, C. F., Rocha, J. B., & Nogueira, C. W. (2010). Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of bis selenide in the mouse tail suspension test. European Journal of Pharmacology, 635(1-3), 135-41. https://doi.org/10.1016/j.ejphar.2010.03.019
Jesse CR, et al. Involvement of L-arginine-nitric Oxide-cyclic Guanosine Monophosphate Pathway in the Antidepressant-like Effect of Bis Selenide in the Mouse Tail Suspension Test. Eur J Pharmacol. 2010 Jun 10;635(1-3):135-41. PubMed PMID: 20307533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of bis selenide in the mouse tail suspension test. AU - Jesse,Cristiano R, AU - Wilhelm,Ethel A, AU - Bortolatto,Cristiani F, AU - Rocha,João B T, AU - Nogueira,Cristina W, Y1 - 2010/03/20/ PY - 2009/08/17/received PY - 2010/02/20/revised PY - 2010/03/04/accepted PY - 2010/3/24/entrez PY - 2010/3/24/pubmed PY - 2010/8/18/medline SP - 135 EP - 41 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 635 IS - 1-3 N2 - The present study investigated a possible antidepressant-like effect of bis selenide by using the forced swimming and the tail suspension tests. The involvement of the l-arginine-nitric oxide-cyclic guanosine monophosphate signaling pathway in the antidepressant-like action of bis selenide was investigated. Bis selenide, given by oral route at doses of 0.5-5mg/kg, decreased the immobility time in the forced swimming and tail suspension tests. Pretreatment with l-arginine (750mg/kg, intraperitoneal, i.p., a nitric oxide precursor), sildenafil (5mg/kg, i.p., a phosphodiesterase 5 inhibitor) or S-nitroso-N-acetyl-penicillamine (25microg/site, intracerebroventricular, i.c.v., a nitric oxide donor) reversed the reduction in the immobility time elicited by bis selenide (1mg/kg, p.o.) in the tail suspension test. Bis selenide (0.1mg/kg, p.o., a subeffective dose) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine (0.3mg/kg, i.p., an inhibitor of nitric oxide synthase) or 7-nitroindazole (25mg/kg, i.p., a specific neuronal nitric oxide synthase inhibitor) in the tail suspension test. Pretreatment of animals with methylene blue (10mg/kg, i.p., an inhibitor of nitric oxide synthase and soluble guanylate cyclase) or 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one (30pmol, i.c.v., a specific inhibitor of soluble guanylate cyclase), at subeffective doses, caused a synergistic effect with bis selenide in the tail suspension test. Bis selenide (1mg/kg, p.o.), at an effective dose in the forced swimming and tail suspension tests, caused a significant decrease in the mouse cerebral nitrate/nitrite levels. The antidepressant-like effect of bis selenide in the tail suspension test is dependent on the inhibition of the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/20307533/Involvement_of_L_arginine_nitric_oxide_cyclic_guanosine_monophosphate_pathway_in_the_antidepressant_like_effect_of_bis_selenide_in_the_mouse_tail_suspension_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(10)00213-X DB - PRIME DP - Unbound Medicine ER -