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Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma.
J Ethnopharmacol. 2010 May 27; 129(2):208-13.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Butea monosperma (Lam.) (Fabaceae) popularly known as 'flame of the forest' has been widely used in the traditional Indian medical system of 'Ayurveda' for the treatment of a variety of ailments including liver disorders.

AIM OF THE STUDY

To evaluate the antioxidative, anti-inflammatory, hepatoprotective and anti-cancer activities of the aqueous extract of Butea monosperma flowers.

MATERIALS AND METHODS

Dried flowers of Butea monosperma were extracted with water. The extract was tested for its anti-proliferative, pro-apoptotic and anti-carcinogenic effects in hepatoma cell lines. The chemopreventive and anti-angiogenic effects of the extract were evaluated by its daily oral administration in a HBV-related X15-myc mouse model of hepatocellular carcinoma (HCC).

RESULTS

Treatment with the aqueous extract inhibited cell proliferation and accumulation of cells in G1 phase. This was accompanied by a marked reduction in the levels of activated Erk1/2 and SAPK/JNK and induction of apoptotic cell death. Oral administration of the extract in transgenic mice conferred hepatoprotection as is evident from normal serum ALT levels and improved liver histopathology and lowered serum VEGF level.

CONCLUSIONS

The ability of aqueous extract of Butea monosperma flowers to impose growth arrest and trigger pro-apoptotic death in cell culture strongly correlated with its strong chemopreventive effect in vivo when given orally.

Authors+Show Affiliations

International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20307637

Citation

Choedon, Tenzin, et al. "Chemopreventive and Anti-cancer Properties of the Aqueous Extract of Flowers of Butea Monosperma." Journal of Ethnopharmacology, vol. 129, no. 2, 2010, pp. 208-13.
Choedon T, Shukla SK, Kumar V. Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. J Ethnopharmacol. 2010;129(2):208-13.
Choedon, T., Shukla, S. K., & Kumar, V. (2010). Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. Journal of Ethnopharmacology, 129(2), 208-13. https://doi.org/10.1016/j.jep.2010.03.011
Choedon T, Shukla SK, Kumar V. Chemopreventive and Anti-cancer Properties of the Aqueous Extract of Flowers of Butea Monosperma. J Ethnopharmacol. 2010 May 27;129(2):208-13. PubMed PMID: 20307637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. AU - Choedon,Tenzin, AU - Shukla,Surendra Kumar, AU - Kumar,Vijay, Y1 - 2010/03/20/ PY - 2009/10/29/received PY - 2010/02/09/revised PY - 2010/03/13/accepted PY - 2010/3/24/entrez PY - 2010/3/24/pubmed PY - 2010/10/29/medline SP - 208 EP - 13 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 129 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Butea monosperma (Lam.) (Fabaceae) popularly known as 'flame of the forest' has been widely used in the traditional Indian medical system of 'Ayurveda' for the treatment of a variety of ailments including liver disorders. AIM OF THE STUDY: To evaluate the antioxidative, anti-inflammatory, hepatoprotective and anti-cancer activities of the aqueous extract of Butea monosperma flowers. MATERIALS AND METHODS: Dried flowers of Butea monosperma were extracted with water. The extract was tested for its anti-proliferative, pro-apoptotic and anti-carcinogenic effects in hepatoma cell lines. The chemopreventive and anti-angiogenic effects of the extract were evaluated by its daily oral administration in a HBV-related X15-myc mouse model of hepatocellular carcinoma (HCC). RESULTS: Treatment with the aqueous extract inhibited cell proliferation and accumulation of cells in G1 phase. This was accompanied by a marked reduction in the levels of activated Erk1/2 and SAPK/JNK and induction of apoptotic cell death. Oral administration of the extract in transgenic mice conferred hepatoprotection as is evident from normal serum ALT levels and improved liver histopathology and lowered serum VEGF level. CONCLUSIONS: The ability of aqueous extract of Butea monosperma flowers to impose growth arrest and trigger pro-apoptotic death in cell culture strongly correlated with its strong chemopreventive effect in vivo when given orally. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/20307637/Chemopreventive_and_anti_cancer_properties_of_the_aqueous_extract_of_flowers_of_Butea_monosperma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00173-X DB - PRIME DP - Unbound Medicine ER -