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Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated mice.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The plant Cleome gynandra L. (Capparidaceae), is commonly known as 'Hurhur'and 'Karaila' in India and 'Cat's whiskers' in English. Traditionally the whole plant is used in the treatment of tumor, anti-inflammatory and lysosomal stability actions.

AIM OF STUDY

The objective of present study is to explore the anticancer activity of the methanol extract of the Cleome gynandra in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line.

MATERIALS AND METHODS

Anticancer activity of methanol extract of Cleome gynandra (MECG) was evaluated in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line at the doses of 200 and 400mg/kg body weight intraperitoneally. MECG was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect of MECG assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host.

RESULTS

MECG showed significant decrease in (p<0.01) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile such as RBC, hemoglobin, WBC and lymphocyte count reverted to normal level in MECG treated mice.

CONCLUSION

From the result it was showed that the extract has potent dose dependent anticancer activity and that is comparable to that of 5-fluorouracil.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pharmaceutical Technology, Jadavpur University, Raja S. C. Mullik Road, Kolkata 700032, West Bengal, India. asisbala_ju@yahoo.co.in

    , , ,

    Source

    Journal of ethnopharmacology 129:1 2010 May 4 pg 131-4

    MeSH

    Animals
    Antineoplastic Agents, Phytogenic
    Blood Cell Count
    Carcinoma, Ehrlich Tumor
    Cell Proliferation
    Cleome
    Hematologic Tests
    Hemoglobins
    Injections, Intraperitoneal
    Male
    Mice
    Phytotherapy
    Plant Extracts

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20307641

    Citation

    TY - JOUR T1 - Evaluation of anticancer activity of Cleome gynandra on Ehrlich's Ascites Carcinoma treated mice. AU - Bala,Asis, AU - Kar,Biswakanth, AU - Haldar,Pallab K, AU - Mazumder,Upal K, AU - Bera,Samit, Y1 - 2010/03/20/ PY - 2009/8/27/received PY - 2010/2/16/revised PY - 2010/3/13/accepted PY - 2010/3/20/aheadofprint PY - 2010/3/24/entrez PY - 2010/3/24/pubmed PY - 2010/10/7/medline SP - 131 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 129 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The plant Cleome gynandra L. (Capparidaceae), is commonly known as 'Hurhur'and 'Karaila' in India and 'Cat's whiskers' in English. Traditionally the whole plant is used in the treatment of tumor, anti-inflammatory and lysosomal stability actions. AIM OF STUDY: The objective of present study is to explore the anticancer activity of the methanol extract of the Cleome gynandra in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line. MATERIALS AND METHODS: Anticancer activity of methanol extract of Cleome gynandra (MECG) was evaluated in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line at the doses of 200 and 400mg/kg body weight intraperitoneally. MECG was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect of MECG assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. RESULTS: MECG showed significant decrease in (p<0.01) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile such as RBC, hemoglobin, WBC and lymphocyte count reverted to normal level in MECG treated mice. CONCLUSION: From the result it was showed that the extract has potent dose dependent anticancer activity and that is comparable to that of 5-fluorouracil. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/20307641/Evaluation_of_anticancer_activity_of_Cleome_gynandra_on_Ehrlich's_Ascites_Carcinoma_treated_mice_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00172-8 ER -