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Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses.
Vet Parasitol. 2010 Jul 15; 171(1-2):106-10.VP

Abstract

In recent years, numerous veterinary practitioners have reported anecdotal episodes in which anthelmintic treatment did not appear to deliver the expected efficacy against equine pinworms (Oxyuris equi). Anthelmintic resistance has not been demonstrated formally in equine pinworms, so a clinical study was designed to evaluate the efficacy of paste formulations of pyrantel pamoate or ivermectin against naturally acquired infections with O. equi. Twenty-one horses (>4 months to 15 years of age) with patent, naturally acquired pinworm infections were blocked by source of origin and allocated randomly to one of three treatment groups: horses (n=7) assigned to Group 1 were treated orally with pyrantel pamoate paste at a dosage of 13.2 mg/kg (2x label dosage), Group 2 horses (n=7) were untreated controls, and horses (n=7) assigned to Group 3 were treated orally with ivermectin paste at a dosage of 200 microg/kg. Fourteen days after treatment, horses were euthanatized, necropsied, and large intestinal contents were processed for recovery of adult pinworms. In addition, duplicate 1% aliquots of intestinal contents from the cecum, ventral colon, dorsal colon, and small colon were collected, preserved, and examined for recovery and enumeration of fourth-stage larval O. equi. Anthelmintic efficacy against pinworms was evaluated by comparing the post-treatment worm counts of Groups 1 and 3 to those of control animals. Mean numbers of O. equi adults recovered postmortem were significantly decreased by both pyrantel pamoate (P=0.0366) and ivermectin (P=0.0137) treatment, with respective efficacies of 91.2% and 96.0%. In addition, both products demonstrated >99% efficacy against fourth-stage O. equi larvae. The current study demonstrated acceptable adulticidal and larvicidal efficacy of both pyrantel pamoate and ivermectin paste formulations against O. equi and did not support the existence of macrocyclic lactone or pyrimidine resistance in the pinworm populations evaluated.

Authors+Show Affiliations

East Tennessee Clinical Research, Inc., 80 Copper Ridge Farm Road, Rockwood, TN 37854, United States. crr@easttenncr.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20307935

Citation

Reinemeyer, Craig R., et al. "Efficacy of Pyrantel Pamoate and Ivermectin Paste Formulations Against Naturally Acquired Oxyuris Equi Infections in Horses." Veterinary Parasitology, vol. 171, no. 1-2, 2010, pp. 106-10.
Reinemeyer CR, Prado JC, Nichols EC, et al. Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses. Vet Parasitol. 2010;171(1-2):106-10.
Reinemeyer, C. R., Prado, J. C., Nichols, E. C., & Marchiondo, A. A. (2010). Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses. Veterinary Parasitology, 171(1-2), 106-10. https://doi.org/10.1016/j.vetpar.2010.02.042
Reinemeyer CR, et al. Efficacy of Pyrantel Pamoate and Ivermectin Paste Formulations Against Naturally Acquired Oxyuris Equi Infections in Horses. Vet Parasitol. 2010 Jul 15;171(1-2):106-10. PubMed PMID: 20307935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of pyrantel pamoate and ivermectin paste formulations against naturally acquired Oxyuris equi infections in horses. AU - Reinemeyer,Craig R, AU - Prado,Julio C, AU - Nichols,Eric C, AU - Marchiondo,Alan A, Y1 - 2010/03/03/ PY - 2009/12/30/received PY - 2010/02/24/revised PY - 2010/02/24/accepted PY - 2010/3/24/entrez PY - 2010/3/24/pubmed PY - 2010/10/1/medline SP - 106 EP - 10 JF - Veterinary parasitology JO - Vet Parasitol VL - 171 IS - 1-2 N2 - In recent years, numerous veterinary practitioners have reported anecdotal episodes in which anthelmintic treatment did not appear to deliver the expected efficacy against equine pinworms (Oxyuris equi). Anthelmintic resistance has not been demonstrated formally in equine pinworms, so a clinical study was designed to evaluate the efficacy of paste formulations of pyrantel pamoate or ivermectin against naturally acquired infections with O. equi. Twenty-one horses (>4 months to 15 years of age) with patent, naturally acquired pinworm infections were blocked by source of origin and allocated randomly to one of three treatment groups: horses (n=7) assigned to Group 1 were treated orally with pyrantel pamoate paste at a dosage of 13.2 mg/kg (2x label dosage), Group 2 horses (n=7) were untreated controls, and horses (n=7) assigned to Group 3 were treated orally with ivermectin paste at a dosage of 200 microg/kg. Fourteen days after treatment, horses were euthanatized, necropsied, and large intestinal contents were processed for recovery of adult pinworms. In addition, duplicate 1% aliquots of intestinal contents from the cecum, ventral colon, dorsal colon, and small colon were collected, preserved, and examined for recovery and enumeration of fourth-stage larval O. equi. Anthelmintic efficacy against pinworms was evaluated by comparing the post-treatment worm counts of Groups 1 and 3 to those of control animals. Mean numbers of O. equi adults recovered postmortem were significantly decreased by both pyrantel pamoate (P=0.0366) and ivermectin (P=0.0137) treatment, with respective efficacies of 91.2% and 96.0%. In addition, both products demonstrated >99% efficacy against fourth-stage O. equi larvae. The current study demonstrated acceptable adulticidal and larvicidal efficacy of both pyrantel pamoate and ivermectin paste formulations against O. equi and did not support the existence of macrocyclic lactone or pyrimidine resistance in the pinworm populations evaluated. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/20307935/Efficacy_of_pyrantel_pamoate_and_ivermectin_paste_formulations_against_naturally_acquired_Oxyuris_equi_infections_in_horses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(10)00135-4 DB - PRIME DP - Unbound Medicine ER -