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Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis.
Neurology. 2010 Mar 23; 74(12):995-1002.Neur

Abstract

BACKGROUND/OBJECTIVE

Anti-inflammatory drugs may prevent Parkinson disease (PD) by inhibiting a putative underlying neuroinflammatory process. We tested the hypothesis that anti-inflammatory drugs reduce PD incidence and that there are differential effects by type of anti-inflammatory, duration of use, or intensity of use.

METHODS

MEDLINE and EMBASE were searched for studies that reported risk of PD associated with anti-inflammatory medications. Random-effects meta-analyses were used to pool results across studies for each type of anti-inflammatory drug. Stratified meta-analyses were used to assess duration- and intensity-response.

RESULTS

Seven studies were identified that met the inclusion criteria, all of which reported associations between nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) and PD, 6 of which reported on aspirin, and 2 of which reported on acetaminophen. Overall, a 15% reduction in PD incidence was observed among users of nonaspirin NSAIDS (relative risk [RR] 0.85, 95% confidence interval [CI] 0.77-0.94), with a similar effect observed for ibuprofen use. The protective effect of nonaspirin NSAIDs was more pronounced among regular users (RR 0.71, 95% CI 0.58-0.89) and long-term users (RR 0.79, 95% CI 0.59-1.07). No protective effect was observed for aspirin (RR 1.08, 95% CI 0.92-1.27) or acetaminophen (RR 1.06, 95% CI 0.87-1.30). Sensitivity analyses found results to be robust.

CONCLUSIONS

There may be a protective effect of nonaspirin nonsteroidal anti-inflammatory drug use on risk of Parkinson disease (PD) consistent with a possible neuroinflammatory pathway in PD pathogenesis.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. jgagne1@partners.orgNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

20308684

Citation

Gagne, Joshua J., and Melinda C. Power. "Anti-inflammatory Drugs and Risk of Parkinson Disease: a Meta-analysis." Neurology, vol. 74, no. 12, 2010, pp. 995-1002.
Gagne JJ, Power MC. Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis. Neurology. 2010;74(12):995-1002.
Gagne, J. J., & Power, M. C. (2010). Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis. Neurology, 74(12), 995-1002. https://doi.org/10.1212/WNL.0b013e3181d5a4a3
Gagne JJ, Power MC. Anti-inflammatory Drugs and Risk of Parkinson Disease: a Meta-analysis. Neurology. 2010 Mar 23;74(12):995-1002. PubMed PMID: 20308684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis. AU - Gagne,Joshua J, AU - Power,Melinda C, PY - 2010/3/24/entrez PY - 2010/3/24/pubmed PY - 2010/4/7/medline SP - 995 EP - 1002 JF - Neurology JO - Neurology VL - 74 IS - 12 N2 - BACKGROUND/OBJECTIVE: Anti-inflammatory drugs may prevent Parkinson disease (PD) by inhibiting a putative underlying neuroinflammatory process. We tested the hypothesis that anti-inflammatory drugs reduce PD incidence and that there are differential effects by type of anti-inflammatory, duration of use, or intensity of use. METHODS: MEDLINE and EMBASE were searched for studies that reported risk of PD associated with anti-inflammatory medications. Random-effects meta-analyses were used to pool results across studies for each type of anti-inflammatory drug. Stratified meta-analyses were used to assess duration- and intensity-response. RESULTS: Seven studies were identified that met the inclusion criteria, all of which reported associations between nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) and PD, 6 of which reported on aspirin, and 2 of which reported on acetaminophen. Overall, a 15% reduction in PD incidence was observed among users of nonaspirin NSAIDS (relative risk [RR] 0.85, 95% confidence interval [CI] 0.77-0.94), with a similar effect observed for ibuprofen use. The protective effect of nonaspirin NSAIDs was more pronounced among regular users (RR 0.71, 95% CI 0.58-0.89) and long-term users (RR 0.79, 95% CI 0.59-1.07). No protective effect was observed for aspirin (RR 1.08, 95% CI 0.92-1.27) or acetaminophen (RR 1.06, 95% CI 0.87-1.30). Sensitivity analyses found results to be robust. CONCLUSIONS: There may be a protective effect of nonaspirin nonsteroidal anti-inflammatory drug use on risk of Parkinson disease (PD) consistent with a possible neuroinflammatory pathway in PD pathogenesis. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/20308684/Anti_inflammatory_drugs_and_risk_of_Parkinson_disease:_a_meta_analysis_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=20308684 DB - PRIME DP - Unbound Medicine ER -