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Impact of different definitions of the metabolic syndrome on the prevalence of organ damage, cardiometabolic risk and cardiovascular events.
J Hypertens. 2010 May; 28(5):999-1006.JH

Abstract

OBJECTIVES

We compared definitions of metabolic syndrome performed by ATPIII [the National Cholesterol Education Program Adult Treatment Panel III; three criteria of the following: systolic blood pressure >or=130 mmHg and/or diastolic blood pressure >or=85 mmHg, fasting serum glucose >or=110 mg/dl, high-density lipoprotein plasma cholesterol <or=40 mg/dl (men) or <or=50 mg/dl (women), plasma triglycerides >or=150 mg/dl, waist circumference >or=102 cm (men) or 88 cm (women)], AHA (the American Heart Association; same cut-off of ATPIII except serum glucose >or= 100 mg/dl) and IDF [the International Diabetes Federation; mandatory criteria of visceral obesity with reduced cut-off of 94 cm (men) or 80 cm (women), and at least two criteria with the same cut-off as in AHA] for their impact on metabolic syndrome prevalence, cardiac organ damage, long-term risk of cardiovascular events and death for any cause and risk of developing diabetes mellitus, in-office and out-of-office hypertension and left ventricular hypertrophy (LVH).

METHODS

In 2051 participants, we measured office, home and ambulatory blood pressure as well as metabolic, anthropometric and echocardiographic variables. Measurements were performed between 1990 and 1992 and repeated 10 years later. Information on long-term incidence of cardiovascular events and all-cause deaths was also collected.

RESULTS

Prevalence of metabolic syndrome was significantly greater when using the AHA and IDF as compared to the ATPIII definition. Prevalence of LVH was higher in participants with than without metabolic syndrome and similar for the three definitions. Over 12-year follow-up, there were 179 cardiovascular events and 233 deaths for any cause. The risk of cardiovascular events and death was markedly greater for participants with as compared with those without metabolic syndrome, regardless of the definition of metabolic syndrome. This was the case also for the risk of new-onset diabetes mellitus, office, home and ambulatory hypertension and new-onset LVH.

CONCLUSION

Risks of fatal and nonfatal cardiovascular events, diabetes mellitus, hypertension and LVH were similar for the three definitions of metabolic syndrome. However, the AHA and IDF definitions are more sensitive than that of ATPIII in identifying metabolic syndrome condition.

Authors+Show Affiliations

Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano-Bicocca, Ospedale San Gerardo dei Tintori, Italy. giuseppe.mancia@unimib.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20308922

Citation

Mancia, Giuseppe, et al. "Impact of Different Definitions of the Metabolic Syndrome On the Prevalence of Organ Damage, Cardiometabolic Risk and Cardiovascular Events." Journal of Hypertension, vol. 28, no. 5, 2010, pp. 999-1006.
Mancia G, Bombelli M, Facchetti R, et al. Impact of different definitions of the metabolic syndrome on the prevalence of organ damage, cardiometabolic risk and cardiovascular events. J Hypertens. 2010;28(5):999-1006.
Mancia, G., Bombelli, M., Facchetti, R., Casati, A., Ronchi, I., Quarti-Trevano, F., Arenare, F., Grassi, G., & Sega, R. (2010). Impact of different definitions of the metabolic syndrome on the prevalence of organ damage, cardiometabolic risk and cardiovascular events. Journal of Hypertension, 28(5), 999-1006. https://doi.org/10.1097/HJH.0b013e328337a9e3
Mancia G, et al. Impact of Different Definitions of the Metabolic Syndrome On the Prevalence of Organ Damage, Cardiometabolic Risk and Cardiovascular Events. J Hypertens. 2010;28(5):999-1006. PubMed PMID: 20308922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of different definitions of the metabolic syndrome on the prevalence of organ damage, cardiometabolic risk and cardiovascular events. AU - Mancia,Giuseppe, AU - Bombelli,Michele, AU - Facchetti,Rita, AU - Casati,Anna, AU - Ronchi,Irene, AU - Quarti-Trevano,Fosca, AU - Arenare,Francesca, AU - Grassi,Guido, AU - Sega,Roberto, PY - 2010/3/24/entrez PY - 2010/3/24/pubmed PY - 2010/7/30/medline SP - 999 EP - 1006 JF - Journal of hypertension JO - J Hypertens VL - 28 IS - 5 N2 - OBJECTIVES: We compared definitions of metabolic syndrome performed by ATPIII [the National Cholesterol Education Program Adult Treatment Panel III; three criteria of the following: systolic blood pressure >or=130 mmHg and/or diastolic blood pressure >or=85 mmHg, fasting serum glucose >or=110 mg/dl, high-density lipoprotein plasma cholesterol <or=40 mg/dl (men) or <or=50 mg/dl (women), plasma triglycerides >or=150 mg/dl, waist circumference >or=102 cm (men) or 88 cm (women)], AHA (the American Heart Association; same cut-off of ATPIII except serum glucose >or= 100 mg/dl) and IDF [the International Diabetes Federation; mandatory criteria of visceral obesity with reduced cut-off of 94 cm (men) or 80 cm (women), and at least two criteria with the same cut-off as in AHA] for their impact on metabolic syndrome prevalence, cardiac organ damage, long-term risk of cardiovascular events and death for any cause and risk of developing diabetes mellitus, in-office and out-of-office hypertension and left ventricular hypertrophy (LVH). METHODS: In 2051 participants, we measured office, home and ambulatory blood pressure as well as metabolic, anthropometric and echocardiographic variables. Measurements were performed between 1990 and 1992 and repeated 10 years later. Information on long-term incidence of cardiovascular events and all-cause deaths was also collected. RESULTS: Prevalence of metabolic syndrome was significantly greater when using the AHA and IDF as compared to the ATPIII definition. Prevalence of LVH was higher in participants with than without metabolic syndrome and similar for the three definitions. Over 12-year follow-up, there were 179 cardiovascular events and 233 deaths for any cause. The risk of cardiovascular events and death was markedly greater for participants with as compared with those without metabolic syndrome, regardless of the definition of metabolic syndrome. This was the case also for the risk of new-onset diabetes mellitus, office, home and ambulatory hypertension and new-onset LVH. CONCLUSION: Risks of fatal and nonfatal cardiovascular events, diabetes mellitus, hypertension and LVH were similar for the three definitions of metabolic syndrome. However, the AHA and IDF definitions are more sensitive than that of ATPIII in identifying metabolic syndrome condition. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/20308922/Impact_of_different_definitions_of_the_metabolic_syndrome_on_the_prevalence_of_organ_damage_cardiometabolic_risk_and_cardiovascular_events_ L2 - https://doi.org/10.1097/HJH.0b013e328337a9e3 DB - PRIME DP - Unbound Medicine ER -