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Intestinal spirochetosis in children: five new cases and a 20-year review of the literature.
Pediatr Dev Pathol. 2010 Nov-Dec; 13(6):471-5.PD

Abstract

Intestinal spirochetosis (IS) is an unusual infection in children, one with no standard therapeutic options. This article reports the findings on 5 new cases in conjunction with a 20-year review of the pediatric literature. The diagnosis of IS in children requires a high degree of suspicion by the physician, as many cases present with abdominal pain, chronic diarrhea, and/or hematochezia associated with a normal endoscopic examination. Silver stains (Dieterle or Whartin-Starry) are the preferred confirmatory stains on tissue sections. Giemsa (Diff-Quik) and periodic acid-Schiff stains may also be of value. Current literature favors the use of metronidazole in adult patients with IS, yet little information is available regarding treatment options in pediatric cases. This review indicates that a macrolide antibiotic with or without metronidazole may represent the best therapeutic choice for children. Further investigations are needed to determine the correlation between IS and coexisting gastrointestinal diseases and/or immunodeficiencies.

Authors+Show Affiliations

Clinical Laboratory, Phoenix Children's Hospital, Phoenix, AZ 85016, USA. dcarpentieri@phoenixchildrens.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

20331366

Citation

Carpentieri, David F., et al. "Intestinal Spirochetosis in Children: Five New Cases and a 20-year Review of the Literature." Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, vol. 13, no. 6, 2010, pp. 471-5.
Carpentieri DF, Souza-Morones S, Gardetto JS, et al. Intestinal spirochetosis in children: five new cases and a 20-year review of the literature. Pediatr Dev Pathol. 2010;13(6):471-5.
Carpentieri, D. F., Souza-Morones, S., Gardetto, J. S., Ross, H. M., Downey, K., Ingebo, K., & Siaw, E. (2010). Intestinal spirochetosis in children: five new cases and a 20-year review of the literature. Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 13(6), 471-5. https://doi.org/10.2350/09-10-0725-CR.1
Carpentieri DF, et al. Intestinal Spirochetosis in Children: Five New Cases and a 20-year Review of the Literature. Pediatr Dev Pathol. 2010 Nov-Dec;13(6):471-5. PubMed PMID: 20331366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal spirochetosis in children: five new cases and a 20-year review of the literature. AU - Carpentieri,David F, AU - Souza-Morones,Stephanie, AU - Gardetto,Jennifer S, AU - Ross,Hillary M, AU - Downey,Katherine, AU - Ingebo,Kristy, AU - Siaw,Emmanuel, Y1 - 2010/03/23/ PY - 2010/3/25/entrez PY - 2010/3/25/pubmed PY - 2011/4/16/medline SP - 471 EP - 5 JF - Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society JO - Pediatr Dev Pathol VL - 13 IS - 6 N2 - Intestinal spirochetosis (IS) is an unusual infection in children, one with no standard therapeutic options. This article reports the findings on 5 new cases in conjunction with a 20-year review of the pediatric literature. The diagnosis of IS in children requires a high degree of suspicion by the physician, as many cases present with abdominal pain, chronic diarrhea, and/or hematochezia associated with a normal endoscopic examination. Silver stains (Dieterle or Whartin-Starry) are the preferred confirmatory stains on tissue sections. Giemsa (Diff-Quik) and periodic acid-Schiff stains may also be of value. Current literature favors the use of metronidazole in adult patients with IS, yet little information is available regarding treatment options in pediatric cases. This review indicates that a macrolide antibiotic with or without metronidazole may represent the best therapeutic choice for children. Further investigations are needed to determine the correlation between IS and coexisting gastrointestinal diseases and/or immunodeficiencies. SN - 1093-5266 UR - https://www.unboundmedicine.com/medline/citation/20331366/Intestinal_spirochetosis_in_children:_five_new_cases_and_a_20_year_review_of_the_literature_ DB - PRIME DP - Unbound Medicine ER -