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Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
Pharmacol Biochem Behav. 2010 Jun; 95(4):434-42.PB

Abstract

The antidepressant action of cannabis as well as the interaction between antidepressants and the endocannabinoid system has been reported. This study was conducted to assess the antidepressant-like activity of Delta(9)-THC and other cannabinoids. Cannabinoids were initially evaluated in the mouse tetrad assay to determine doses that do not induce hypothermia or catalepsy. The automated mouse forced swim (FST) and tail suspension (TST) tests were used to determine antidepressant action. At doses lacking hypothermic and cataleptic effects (1.25, 2.5, and 5 mg/kg, i.p.), both Delta(9)-THC and Delta(8)-THC showed a U-shaped dose response with only Delta(9)-THC showing significant antidepressant-like effects at 2.5 mg/kg (p<0.05) in the FST. The cannabinoids cannabigerol (CBG) and cannabinol (CBN) did not produce antidepressant-like actions up to 80 mg/kg in the mouse FST, while cannabichromene (CBC) and cannabidiol (CBD) exhibited significant effect at 20 and 200mg/kg, respectively (p<0.01). The antidepressant-like action of Delta(9)-THC and CBC was further confirmed in the TST. Delta(9)-THC exhibited the same U-shaped dose response with significant antidepressant-like action at 2.5 mg/kg (p<0.05) while CBC resulted in a significant dose-dependent decrease in immobility at 40 and 80 mg/kg doses (p<0.01). Results of this study show that Delta(9)-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis.

Authors+Show Affiliations

Pharmacology Department, School of Pharmacy, University of Mississippi, University, MS 38677, USA. aalfy2001@olemiss.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20332000

Citation

El-Alfy, Abir T., et al. "Antidepressant-like Effect of Delta9-tetrahydrocannabinol and Other Cannabinoids Isolated From Cannabis Sativa L." Pharmacology, Biochemistry, and Behavior, vol. 95, no. 4, 2010, pp. 434-42.
El-Alfy AT, Ivey K, Robinson K, et al. Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacol Biochem Behav. 2010;95(4):434-42.
El-Alfy, A. T., Ivey, K., Robinson, K., Ahmed, S., Radwan, M., Slade, D., Khan, I., ElSohly, M., & Ross, S. (2010). Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology, Biochemistry, and Behavior, 95(4), 434-42. https://doi.org/10.1016/j.pbb.2010.03.004
El-Alfy AT, et al. Antidepressant-like Effect of Delta9-tetrahydrocannabinol and Other Cannabinoids Isolated From Cannabis Sativa L. Pharmacol Biochem Behav. 2010;95(4):434-42. PubMed PMID: 20332000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. AU - El-Alfy,Abir T, AU - Ivey,Kelly, AU - Robinson,Keisha, AU - Ahmed,Safwat, AU - Radwan,Mohamed, AU - Slade,Desmond, AU - Khan,Ikhlas, AU - ElSohly,Mahmoud, AU - Ross,Samir, Y1 - 2010/03/21/ PY - 2010/01/13/received PY - 2010/03/05/revised PY - 2010/03/13/accepted PY - 2010/3/25/entrez PY - 2010/3/25/pubmed PY - 2010/8/19/medline SP - 434 EP - 42 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 95 IS - 4 N2 - The antidepressant action of cannabis as well as the interaction between antidepressants and the endocannabinoid system has been reported. This study was conducted to assess the antidepressant-like activity of Delta(9)-THC and other cannabinoids. Cannabinoids were initially evaluated in the mouse tetrad assay to determine doses that do not induce hypothermia or catalepsy. The automated mouse forced swim (FST) and tail suspension (TST) tests were used to determine antidepressant action. At doses lacking hypothermic and cataleptic effects (1.25, 2.5, and 5 mg/kg, i.p.), both Delta(9)-THC and Delta(8)-THC showed a U-shaped dose response with only Delta(9)-THC showing significant antidepressant-like effects at 2.5 mg/kg (p<0.05) in the FST. The cannabinoids cannabigerol (CBG) and cannabinol (CBN) did not produce antidepressant-like actions up to 80 mg/kg in the mouse FST, while cannabichromene (CBC) and cannabidiol (CBD) exhibited significant effect at 20 and 200mg/kg, respectively (p<0.01). The antidepressant-like action of Delta(9)-THC and CBC was further confirmed in the TST. Delta(9)-THC exhibited the same U-shaped dose response with significant antidepressant-like action at 2.5 mg/kg (p<0.05) while CBC resulted in a significant dose-dependent decrease in immobility at 40 and 80 mg/kg doses (p<0.01). Results of this study show that Delta(9)-THC and other cannabinoids exert antidepressant-like actions, and thus may contribute to the overall mood-elevating properties of cannabis. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/20332000/Antidepressant_like_effect_of_delta9_tetrahydrocannabinol_and_other_cannabinoids_isolated_from_Cannabis_sativa_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(10)00073-0 DB - PRIME DP - Unbound Medicine ER -