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A prospective study of dietary fat consumption and endometriosis risk.
Hum Reprod 2010; 25(6):1528-35HR

Abstract

BACKGROUND

Endometriosis is a prevalent but enigmatic gynecologic disorder for which few modifiable risk factors have been identified. Fish oil consumption has been associated with symptom improvement in studies of women with primary dysmenorrhea and with decreased endometriosis risk in autotransplantation animal studies.

METHODS

To investigate the relation between dietary fat intake and the risk of endometriosis, we analyzed 12 years of prospective data from the Nurses' Health Study II that began in 1989. Dietary fat was assessed via food frequency questionnaire in 1991, 1995 and 1999. We used Cox proportional hazards models adjusted for total energy intake, parity, race and body mass index at age 18, and assessed cumulatively averaged fat intake across the three diet questionnaires.

RESULTS

During the 586 153 person-years of follow-up, 1199 cases of laparoscopically confirmed endometriosis were reported. Although total fat consumption was not associated with endometriosis risk, those women in the highest fifth of long-chain omega-3 fatty acid consumption were 22% less likely to be diagnosed with endometriosis compared with those with the lowest fifth of intake [95% confidence interval (CI) = 0.62-0.99; P-value, test for linear trend (Pt) = 0.03]. In addition, those in the highest quintile of trans-unsaturated fat intake were 48% more likely to be diagnosed with endometriosis (95% CI = 1.17-1.88; Pt = 0.001).

CONCLUSION

These data suggest that specific types of dietary fat are associated with the incidence of laparoscopically confirmed endometriosis, and that these relations may indicate modifiable risk. This evidence additionally provides another disease association that supports efforts to remove trans fat from hydrogenated oils from the food supply.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115-5804, USA. stacey.missmer@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20332166

Citation

Missmer, Stacey A., et al. "A Prospective Study of Dietary Fat Consumption and Endometriosis Risk." Human Reproduction (Oxford, England), vol. 25, no. 6, 2010, pp. 1528-35.
Missmer SA, Chavarro JE, Malspeis S, et al. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod. 2010;25(6):1528-35.
Missmer, S. A., Chavarro, J. E., Malspeis, S., Bertone-Johnson, E. R., Hornstein, M. D., Spiegelman, D., ... Hankinson, S. E. (2010). A prospective study of dietary fat consumption and endometriosis risk. Human Reproduction (Oxford, England), 25(6), pp. 1528-35. doi:10.1093/humrep/deq044.
Missmer SA, et al. A Prospective Study of Dietary Fat Consumption and Endometriosis Risk. Hum Reprod. 2010;25(6):1528-35. PubMed PMID: 20332166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of dietary fat consumption and endometriosis risk. AU - Missmer,Stacey A, AU - Chavarro,Jorge E, AU - Malspeis,Susan, AU - Bertone-Johnson,Elizabeth R, AU - Hornstein,Mark D, AU - Spiegelman,Donna, AU - Barbieri,Robert L, AU - Willett,Walter C, AU - Hankinson,Susan E, Y1 - 2010/03/23/ PY - 2010/3/25/entrez PY - 2010/3/25/pubmed PY - 2010/8/18/medline SP - 1528 EP - 35 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 25 IS - 6 N2 - BACKGROUND: Endometriosis is a prevalent but enigmatic gynecologic disorder for which few modifiable risk factors have been identified. Fish oil consumption has been associated with symptom improvement in studies of women with primary dysmenorrhea and with decreased endometriosis risk in autotransplantation animal studies. METHODS: To investigate the relation between dietary fat intake and the risk of endometriosis, we analyzed 12 years of prospective data from the Nurses' Health Study II that began in 1989. Dietary fat was assessed via food frequency questionnaire in 1991, 1995 and 1999. We used Cox proportional hazards models adjusted for total energy intake, parity, race and body mass index at age 18, and assessed cumulatively averaged fat intake across the three diet questionnaires. RESULTS: During the 586 153 person-years of follow-up, 1199 cases of laparoscopically confirmed endometriosis were reported. Although total fat consumption was not associated with endometriosis risk, those women in the highest fifth of long-chain omega-3 fatty acid consumption were 22% less likely to be diagnosed with endometriosis compared with those with the lowest fifth of intake [95% confidence interval (CI) = 0.62-0.99; P-value, test for linear trend (Pt) = 0.03]. In addition, those in the highest quintile of trans-unsaturated fat intake were 48% more likely to be diagnosed with endometriosis (95% CI = 1.17-1.88; Pt = 0.001). CONCLUSION: These data suggest that specific types of dietary fat are associated with the incidence of laparoscopically confirmed endometriosis, and that these relations may indicate modifiable risk. This evidence additionally provides another disease association that supports efforts to remove trans fat from hydrogenated oils from the food supply. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/20332166/A_prospective_study_of_dietary_fat_consumption_and_endometriosis_risk_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deq044 DB - PRIME DP - Unbound Medicine ER -