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Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine.
Int J Neuropsychopharmacol. 2010 Nov; 13(10):1315-27.IJ

Abstract

In laboratory animals, exposure to priming injections of 3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following extinction of MDMA self-administration. This study aimed to evaluate whether the magnitude of drug seeking was related to latency to acquisition of MDMA self-administration and increases in striatal dopamine, as measured by in-vivo microdialysis. Rats were given daily access to MDMA self-administration until they earned a total of 240 infusions (total intake of 165 mg/kg MDMA). Twelve of the 20 rats acquired self-administration within the temporal limits of the study and the latency to meet the criterion ranged from 9 d to 37 d. An experimenter-administered injection of MDMA (10.0 mg/kg i.p.) produced drug seeking in these rats, and the number of responses was significantly higher than responses produced by rats that failed to meet the criterion or by yoked control rats that received the drug passively. For rats that met the criterion, drug seeking was negatively correlated with the number of days to self-administer the criterion number of MDMA infusions and positively correlated with MDMA-produced dopamine in the dorsal striatum. Importantly, MDMA-produced dopamine overflow was greater for the rats that met the criterion. These findings suggest that drug seeking is influenced by initial sensitivity to the reinforcing effects of MDMA and to drug-produced increases in striatal dopamine.

Authors+Show Affiliations

Victoria University of Wellington, School of Psychology, Wellington, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20334725

Citation

Colussi-Mas, Joyce, et al. "Drug Seeking in Response to a Priming Injection of MDMA in Rats: Relationship to Initial Sensitivity to Self-administered MDMA and Dorsal Striatal Dopamine." The International Journal of Neuropsychopharmacology, vol. 13, no. 10, 2010, pp. 1315-27.
Colussi-Mas J, Wise RJ, Howard A, et al. Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine. Int J Neuropsychopharmacol. 2010;13(10):1315-27.
Colussi-Mas, J., Wise, R. J., Howard, A., & Schenk, S. (2010). Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine. The International Journal of Neuropsychopharmacology, 13(10), 1315-27. https://doi.org/10.1017/S1461145710000283
Colussi-Mas J, et al. Drug Seeking in Response to a Priming Injection of MDMA in Rats: Relationship to Initial Sensitivity to Self-administered MDMA and Dorsal Striatal Dopamine. Int J Neuropsychopharmacol. 2010;13(10):1315-27. PubMed PMID: 20334725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug seeking in response to a priming injection of MDMA in rats: relationship to initial sensitivity to self-administered MDMA and dorsal striatal dopamine. AU - Colussi-Mas,Joyce, AU - Wise,Richard J, AU - Howard,Alex, AU - Schenk,Susan, Y1 - 2010/03/25/ PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2011/3/19/medline SP - 1315 EP - 27 JF - The international journal of neuropsychopharmacology JO - Int. J. Neuropsychopharmacol. VL - 13 IS - 10 N2 - In laboratory animals, exposure to priming injections of 3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following extinction of MDMA self-administration. This study aimed to evaluate whether the magnitude of drug seeking was related to latency to acquisition of MDMA self-administration and increases in striatal dopamine, as measured by in-vivo microdialysis. Rats were given daily access to MDMA self-administration until they earned a total of 240 infusions (total intake of 165 mg/kg MDMA). Twelve of the 20 rats acquired self-administration within the temporal limits of the study and the latency to meet the criterion ranged from 9 d to 37 d. An experimenter-administered injection of MDMA (10.0 mg/kg i.p.) produced drug seeking in these rats, and the number of responses was significantly higher than responses produced by rats that failed to meet the criterion or by yoked control rats that received the drug passively. For rats that met the criterion, drug seeking was negatively correlated with the number of days to self-administer the criterion number of MDMA infusions and positively correlated with MDMA-produced dopamine in the dorsal striatum. Importantly, MDMA-produced dopamine overflow was greater for the rats that met the criterion. These findings suggest that drug seeking is influenced by initial sensitivity to the reinforcing effects of MDMA and to drug-produced increases in striatal dopamine. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/20334725/Drug_seeking_in_response_to_a_priming_injection_of_MDMA_in_rats:_relationship_to_initial_sensitivity_to_self_administered_MDMA_and_dorsal_striatal_dopamine_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145710000283 DB - PRIME DP - Unbound Medicine ER -