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Reconsolidation of a cocaine-associated stimulus requires amygdalar protein kinase A.
J Neurosci. 2010 Mar 24; 30(12):4401-7.JN

Abstract

Drug addiction is a chronic disorder associated with recurrent craving and relapse often precipitated by the presence of drug-associated stimuli. Pharmacological and behavioral treatments that disrupt drug-associated stimulus memories could be beneficial in the treatment of addictive disorders. Memory restabilization (or reconsolidation) following retrieval of drug-paired stimuli depends upon the amygdala. Here we assessed whether amygdalar PKA is required for the reconsolidation of an appetitive, cocaine-paired stimulus. Rats were trained to lever press for intravenous cocaine infusions paired with a light/tone conditioned stimulus. After 12 d of acquisition, rats either underwent lever extinction (8-12 d) followed by light/tone reactivation and subsequent cue-induced and cocaine-induced (15 mg/kg, i.p.) reinstatement testing or were subsequently tested to assess the ability of the light/tone stimulus to serve as a conditioned reinforcer in the acquisition of a new instrumental response (nose poking). Bilateral intra-amygdalar infusions of the PKA inhibitor Rp-cAMPS (18 microg per side) given immediately following light/tone stimulus reactivation decreased subsequent cue-induced reinstatement and responding with a conditioned reinforcer, while having no effect on cocaine-induced reinstatement. Intra-amygdalar infusions of Rp-cAMPS made 3 h following reactivation or immediately following no stimulus reactivation had no effect on subsequent cue-induced reinstatement. These data show that memory reconsolidation for a cocaine-paired stimulus is retrieval dependent and time limited and critically depends upon amygdalar PKA.

Authors+Show Affiliations

Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20335476

Citation

Sanchez, Hayde, et al. "Reconsolidation of a Cocaine-associated Stimulus Requires Amygdalar Protein Kinase A." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 30, no. 12, 2010, pp. 4401-7.
Sanchez H, Quinn JJ, Torregrossa MM, et al. Reconsolidation of a cocaine-associated stimulus requires amygdalar protein kinase A. J Neurosci. 2010;30(12):4401-7.
Sanchez, H., Quinn, J. J., Torregrossa, M. M., & Taylor, J. R. (2010). Reconsolidation of a cocaine-associated stimulus requires amygdalar protein kinase A. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 30(12), 4401-7. https://doi.org/10.1523/JNEUROSCI.3149-09.2010
Sanchez H, et al. Reconsolidation of a Cocaine-associated Stimulus Requires Amygdalar Protein Kinase A. J Neurosci. 2010 Mar 24;30(12):4401-7. PubMed PMID: 20335476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reconsolidation of a cocaine-associated stimulus requires amygdalar protein kinase A. AU - Sanchez,Hayde, AU - Quinn,Jennifer J, AU - Torregrossa,Mary M, AU - Taylor,Jane R, PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/4/21/medline SP - 4401 EP - 7 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 30 IS - 12 N2 - Drug addiction is a chronic disorder associated with recurrent craving and relapse often precipitated by the presence of drug-associated stimuli. Pharmacological and behavioral treatments that disrupt drug-associated stimulus memories could be beneficial in the treatment of addictive disorders. Memory restabilization (or reconsolidation) following retrieval of drug-paired stimuli depends upon the amygdala. Here we assessed whether amygdalar PKA is required for the reconsolidation of an appetitive, cocaine-paired stimulus. Rats were trained to lever press for intravenous cocaine infusions paired with a light/tone conditioned stimulus. After 12 d of acquisition, rats either underwent lever extinction (8-12 d) followed by light/tone reactivation and subsequent cue-induced and cocaine-induced (15 mg/kg, i.p.) reinstatement testing or were subsequently tested to assess the ability of the light/tone stimulus to serve as a conditioned reinforcer in the acquisition of a new instrumental response (nose poking). Bilateral intra-amygdalar infusions of the PKA inhibitor Rp-cAMPS (18 microg per side) given immediately following light/tone stimulus reactivation decreased subsequent cue-induced reinstatement and responding with a conditioned reinforcer, while having no effect on cocaine-induced reinstatement. Intra-amygdalar infusions of Rp-cAMPS made 3 h following reactivation or immediately following no stimulus reactivation had no effect on subsequent cue-induced reinstatement. These data show that memory reconsolidation for a cocaine-paired stimulus is retrieval dependent and time limited and critically depends upon amygdalar PKA. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/20335476/Reconsolidation_of_a_cocaine_associated_stimulus_requires_amygdalar_protein_kinase_A_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=20335476 DB - PRIME DP - Unbound Medicine ER -