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Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: preliminary results.

Abstract

BACKGROUND

In cartilage repair, bioregenerative approaches using tissue engineering techniques have tried to achieve a close resemblance to hyaline cartilage, which might be visualized using advanced magnetic resonance imaging.

PURPOSE

To compare cartilage repair tissue at the femoral condyle noninvasively after matrix-associated autologous chondrocyte transplantation using Hyalograft C, a hyaluronic-based scaffold, to cartilage repair tissue after transplantation using CaReS, a collagen-based scaffold, with magnetic resonance imaging using morphologic scoring and T2 mapping.

STUDY DESIGN

Cohort study; Level of evidence, 3.

METHODS

Twenty patients after matrix-associated autologous chondrocyte transplantation (Hyalograft C, n = 10; CaReS, n = 10) underwent 3-T magnetic resonance imaging 24 months after surgery. Groups were matched by age and defect size/localization. For clinical outcome, the Brittberg score was assessed. Morphologic analysis was applied using the magnetic resonance observation of cartilage repair tissue score, and global and zonal biochemical T2 mapping was performed to reflect biomechanical properties with regard to collagen matrix/content and hydration.

RESULTS

The clinical outcome was comparable in each group. The magnetic resonance observation of cartilage repair tissue score showed slightly but not significantly (P= .210) better results in the CaReS group (76.5) compared to the Hyalograft C group (70.0), with significantly better (P= .004) constitution of the surface of the repair tissue in the CaReS group. Global T2 relaxation times (milliseconds) for healthy surrounding cartilage were comparable in both groups (Hyalograft C, 49.9; CaReS, 51.9; P= .398), whereas cartilage repair tissue showed significantly higher results in the CaReS group (Hyalograft C, 48.2; CaReS, 55.5; P= .011). Zonal evaluation showed no significant differences (P > or = .05).

CONCLUSION

Most morphologic parameters provided comparable results for both repair tissues. However, differences in the surface and higher T2 values for the cartilage repair tissue that was based on a collagen scaffold (CaReS), compared to the hyaluronic-based scaffold, indicated differences in the composition of the repair tissue even 2 years postimplantation.

CLINICAL RELEVANCE

In the follow-up of cartilage repair procedures using matrix-associated autologous chondrocyte transplantation, differences due to scaffolds have to be taken into account.

Links

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  • Authors+Show Affiliations

    ,

    MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria. welsch@bwh.harvard.edu

    , , , , ,

    Source

    MeSH

    Adult
    Cartilage, Articular
    Chondrocytes
    Cohort Studies
    Collagen
    Humans
    Hyaluronic Acid
    Knee Joint
    Orthopedic Procedures
    Reconstructive Surgical Procedures
    Tissue Scaffolds
    Transplantation, Autologous
    Treatment Outcome
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20335510

    Citation

    Welsch, Goetz Hannes, et al. "Evaluation of Cartilage Repair Tissue After Matrix-associated Autologous Chondrocyte Transplantation Using a Hyaluronic-based or a Collagen-based Scaffold With Morphological MOCART Scoring and Biochemical T2 Mapping: Preliminary Results." The American Journal of Sports Medicine, vol. 38, no. 5, 2010, pp. 934-42.
    Welsch GH, Mamisch TC, Zak L, et al. Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: preliminary results. Am J Sports Med. 2010;38(5):934-42.
    Welsch, G. H., Mamisch, T. C., Zak, L., Blanke, M., Olk, A., Marlovits, S., & Trattnig, S. (2010). Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: preliminary results. The American Journal of Sports Medicine, 38(5), pp. 934-42. doi:10.1177/0363546509354971.
    Welsch GH, et al. Evaluation of Cartilage Repair Tissue After Matrix-associated Autologous Chondrocyte Transplantation Using a Hyaluronic-based or a Collagen-based Scaffold With Morphological MOCART Scoring and Biochemical T2 Mapping: Preliminary Results. Am J Sports Med. 2010;38(5):934-42. PubMed PMID: 20335510.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: preliminary results. AU - Welsch,Goetz Hannes, AU - Mamisch,Tallal Charles, AU - Zak,Lukas, AU - Blanke,Matthias, AU - Olk,Alexander, AU - Marlovits,Stefan, AU - Trattnig,Siegfried, Y1 - 2010/03/24/ PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/7/30/medline SP - 934 EP - 42 JF - The American journal of sports medicine JO - Am J Sports Med VL - 38 IS - 5 N2 - BACKGROUND: In cartilage repair, bioregenerative approaches using tissue engineering techniques have tried to achieve a close resemblance to hyaline cartilage, which might be visualized using advanced magnetic resonance imaging. PURPOSE: To compare cartilage repair tissue at the femoral condyle noninvasively after matrix-associated autologous chondrocyte transplantation using Hyalograft C, a hyaluronic-based scaffold, to cartilage repair tissue after transplantation using CaReS, a collagen-based scaffold, with magnetic resonance imaging using morphologic scoring and T2 mapping. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Twenty patients after matrix-associated autologous chondrocyte transplantation (Hyalograft C, n = 10; CaReS, n = 10) underwent 3-T magnetic resonance imaging 24 months after surgery. Groups were matched by age and defect size/localization. For clinical outcome, the Brittberg score was assessed. Morphologic analysis was applied using the magnetic resonance observation of cartilage repair tissue score, and global and zonal biochemical T2 mapping was performed to reflect biomechanical properties with regard to collagen matrix/content and hydration. RESULTS: The clinical outcome was comparable in each group. The magnetic resonance observation of cartilage repair tissue score showed slightly but not significantly (P= .210) better results in the CaReS group (76.5) compared to the Hyalograft C group (70.0), with significantly better (P= .004) constitution of the surface of the repair tissue in the CaReS group. Global T2 relaxation times (milliseconds) for healthy surrounding cartilage were comparable in both groups (Hyalograft C, 49.9; CaReS, 51.9; P= .398), whereas cartilage repair tissue showed significantly higher results in the CaReS group (Hyalograft C, 48.2; CaReS, 55.5; P= .011). Zonal evaluation showed no significant differences (P > or = .05). CONCLUSION: Most morphologic parameters provided comparable results for both repair tissues. However, differences in the surface and higher T2 values for the cartilage repair tissue that was based on a collagen scaffold (CaReS), compared to the hyaluronic-based scaffold, indicated differences in the composition of the repair tissue even 2 years postimplantation. CLINICAL RELEVANCE: In the follow-up of cartilage repair procedures using matrix-associated autologous chondrocyte transplantation, differences due to scaffolds have to be taken into account. SN - 1552-3365 UR - https://www.unboundmedicine.com/medline/citation/20335510/Evaluation_of_cartilage_repair_tissue_after_matrix_associated_autologous_chondrocyte_transplantation_using_a_hyaluronic_based_or_a_collagen_based_scaffold_with_morphological_MOCART_scoring_and_biochemical_T2_mapping:_preliminary_results_ L2 - http://journals.sagepub.com/doi/full/10.1177/0363546509354971?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -