Tags

Type your tag names separated by a space and hit enter

FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.
Am J Clin Nutr. 2010 May; 91(5):1368-76.AJ

Abstract

BACKGROUND

The genes encoding Delta(5)- and Delta(6)-desaturases (FADS1 FADS2 gene cluster) were reported to be associated with n-3 (omega-3) and n-6 (omega-6) fatty acid proportions in human plasma, tissues, and milk. Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from alpha-linolenic acid through a pathway involving these desaturases.

OBJECTIVE

We evaluated whether FADS gene variants modify the effect of maternal fish and fish-oil intake on plasma and milk DHA proportions.

DESIGN

FADS1 rs174561, FADS2 rs174575, and intergenic rs3834458 single nucleotide polymorphisms were genotyped in 309 women from the KOALA Birth Cohort Study in The Netherlands. Plasma was collected at 36 wk of pregnancy, and milk was collected at 1 mo postpartum. Fish and fish-oil intake was assessed by using a food-frequency questionnaire at 34 wk of pregnancy and updated for the week of milk collection. Gene-diet interactions were tested by linear regression analysis.

RESULTS

DHA proportions were lower in women homozygous for the minor allele than in women who were homozygous for the major allele (DHA proportions in plasma phospholipids: P < 0.01; DHA proportions in milk: P < 0.05). Fish intake ranged from 0 to 2.5 portions of fatty fish/wk, and 12 women took fish-oil supplements during pregnancy. DHA proportions in plasma phospholipids increased with increasing fish and fish-oil intake, irrespective of the genotype. DHA proportions in milk increased only with fish and fish-oil intake in the major-allele carriers.

CONCLUSION

Lower proportions of DHA in milk from women who were homozygous for the minor allele could not be compensated for by increasing fish and fish-oil intake, possibly because of limited incorporation into milk.

Authors+Show Affiliations

Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20335541

Citation

Moltó-Puigmartí, Carolina, et al. "FADS1 FADS2 Gene Variants Modify the Association Between Fish Intake and the Docosahexaenoic Acid Proportions in Human Milk." The American Journal of Clinical Nutrition, vol. 91, no. 5, 2010, pp. 1368-76.
Moltó-Puigmartí C, Plat J, Mensink RP, et al. FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. Am J Clin Nutr. 2010;91(5):1368-76.
Moltó-Puigmartí, C., Plat, J., Mensink, R. P., Müller, A., Jansen, E., Zeegers, M. P., & Thijs, C. (2010). FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. The American Journal of Clinical Nutrition, 91(5), 1368-76. https://doi.org/10.3945/ajcn.2009.28789
Moltó-Puigmartí C, et al. FADS1 FADS2 Gene Variants Modify the Association Between Fish Intake and the Docosahexaenoic Acid Proportions in Human Milk. Am J Clin Nutr. 2010;91(5):1368-76. PubMed PMID: 20335541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. AU - Moltó-Puigmartí,Carolina, AU - Plat,Jogchum, AU - Mensink,Ronald P, AU - Müller,André, AU - Jansen,Eugène, AU - Zeegers,Maurice P, AU - Thijs,Carel, Y1 - 2010/03/24/ PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/5/29/medline SP - 1368 EP - 76 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 91 IS - 5 N2 - BACKGROUND: The genes encoding Delta(5)- and Delta(6)-desaturases (FADS1 FADS2 gene cluster) were reported to be associated with n-3 (omega-3) and n-6 (omega-6) fatty acid proportions in human plasma, tissues, and milk. Docosahexaenoic acid (DHA) can be supplied especially by dietary fish or fish oil and synthesized from alpha-linolenic acid through a pathway involving these desaturases. OBJECTIVE: We evaluated whether FADS gene variants modify the effect of maternal fish and fish-oil intake on plasma and milk DHA proportions. DESIGN: FADS1 rs174561, FADS2 rs174575, and intergenic rs3834458 single nucleotide polymorphisms were genotyped in 309 women from the KOALA Birth Cohort Study in The Netherlands. Plasma was collected at 36 wk of pregnancy, and milk was collected at 1 mo postpartum. Fish and fish-oil intake was assessed by using a food-frequency questionnaire at 34 wk of pregnancy and updated for the week of milk collection. Gene-diet interactions were tested by linear regression analysis. RESULTS: DHA proportions were lower in women homozygous for the minor allele than in women who were homozygous for the major allele (DHA proportions in plasma phospholipids: P < 0.01; DHA proportions in milk: P < 0.05). Fish intake ranged from 0 to 2.5 portions of fatty fish/wk, and 12 women took fish-oil supplements during pregnancy. DHA proportions in plasma phospholipids increased with increasing fish and fish-oil intake, irrespective of the genotype. DHA proportions in milk increased only with fish and fish-oil intake in the major-allele carriers. CONCLUSION: Lower proportions of DHA in milk from women who were homozygous for the minor allele could not be compensated for by increasing fish and fish-oil intake, possibly because of limited incorporation into milk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20335541/FADS1_FADS2_gene_variants_modify_the_association_between_fish_intake_and_the_docosahexaenoic_acid_proportions_in_human_milk_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28789 DB - PRIME DP - Unbound Medicine ER -