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Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes.
Am J Clin Nutr. 2010 May; 91(5):1394-401.AJ

Abstract

BACKGROUND

In vitro and animal studies have suggested that soy protein and isoflavones have favorable effects on glucose and insulin regulation, but intervention studies in humans are limited, and the results are controversial.

OBJECTIVE

We investigated whether soy protein with isoflavones and soy isoflavone extracts could improve glycemic control and insulin sensitivity in postmenopausal women with early hyperglycemia.

DESIGN

This was a randomized, double-blind, placebo-controlled trial that included 180 postmenopausal Hong Kong Chinese women with prediabetes or early untreated diabetes. After a 2-wk adaptation period, participants were randomly assigned to 1 of 3 arms to receive 15 g soy protein and 100 mg isoflavones, 15 g milk protein and 100 mg isoflavones, or 15 g milk protein on a daily basis for 6 mo.

RESULTS

Three- or 6-mo treatments with soy protein with or without isoflavone supplementation did not result in favorable changes in the descriptors for glycemic control and insulin resistance, namely fasting and 2-h postload glucose, fasting and postload insulin, glycated serum protein, and homeostasis model assessment for insulin resistance and beta-cell function.

CONCLUSIONS

This 6-mo randomized controlled trial did not support the hypothesis that soy protein with or without isoflavone supplementation had favorable effects on glycemic control and insulin sensitivity among postmenopausal Chinese women. The favorable change in postload glucose needs to be further confirmed.

Authors+Show Affiliations

Centre of Research and Promotion of Women's Health, School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20335543

Citation

Liu, Zhao-min, et al. "Effects of Soy Protein and Isoflavones On Glycemic Control and Insulin Sensitivity: a 6-mo Double-blind, Randomized, Placebo-controlled Trial in Postmenopausal Chinese Women With Prediabetes or Untreated Early Diabetes." The American Journal of Clinical Nutrition, vol. 91, no. 5, 2010, pp. 1394-401.
Liu ZM, Chen YM, Ho SC, et al. Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. Am J Clin Nutr. 2010;91(5):1394-401.
Liu, Z. M., Chen, Y. M., Ho, S. C., Ho, Y. P., & Woo, J. (2010). Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. The American Journal of Clinical Nutrition, 91(5), 1394-401. https://doi.org/10.3945/ajcn.2009.28813
Liu ZM, et al. Effects of Soy Protein and Isoflavones On Glycemic Control and Insulin Sensitivity: a 6-mo Double-blind, Randomized, Placebo-controlled Trial in Postmenopausal Chinese Women With Prediabetes or Untreated Early Diabetes. Am J Clin Nutr. 2010;91(5):1394-401. PubMed PMID: 20335543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. AU - Liu,Zhao-min, AU - Chen,Yu-ming, AU - Ho,Suzanne C, AU - Ho,Yee Ping, AU - Woo,Jean, Y1 - 2010/03/24/ PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/5/29/medline SP - 1394 EP - 401 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 91 IS - 5 N2 - BACKGROUND: In vitro and animal studies have suggested that soy protein and isoflavones have favorable effects on glucose and insulin regulation, but intervention studies in humans are limited, and the results are controversial. OBJECTIVE: We investigated whether soy protein with isoflavones and soy isoflavone extracts could improve glycemic control and insulin sensitivity in postmenopausal women with early hyperglycemia. DESIGN: This was a randomized, double-blind, placebo-controlled trial that included 180 postmenopausal Hong Kong Chinese women with prediabetes or early untreated diabetes. After a 2-wk adaptation period, participants were randomly assigned to 1 of 3 arms to receive 15 g soy protein and 100 mg isoflavones, 15 g milk protein and 100 mg isoflavones, or 15 g milk protein on a daily basis for 6 mo. RESULTS: Three- or 6-mo treatments with soy protein with or without isoflavone supplementation did not result in favorable changes in the descriptors for glycemic control and insulin resistance, namely fasting and 2-h postload glucose, fasting and postload insulin, glycated serum protein, and homeostasis model assessment for insulin resistance and beta-cell function. CONCLUSIONS: This 6-mo randomized controlled trial did not support the hypothesis that soy protein with or without isoflavone supplementation had favorable effects on glycemic control and insulin sensitivity among postmenopausal Chinese women. The favorable change in postload glucose needs to be further confirmed. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20335543/Effects_of_soy_protein_and_isoflavones_on_glycemic_control_and_insulin_sensitivity:_a_6_mo_double_blind_randomized_placebo_controlled_trial_in_postmenopausal_Chinese_women_with_prediabetes_or_untreated_early_diabetes_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28813 DB - PRIME DP - Unbound Medicine ER -