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Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women.
Am J Clin Nutr. 2010 May; 91(5):1268-72.AJ

Abstract

BACKGROUND

Many women use multivitamins in the belief that these supplements will prevent chronic diseases such as cancer and cardiovascular disease. However, whether the use of multivitamins affects the risk of breast cancer is unclear.

OBJECTIVE

We prospectively examined the association between multivitamin use and the incidence of invasive breast cancer in the Swedish Mammography Cohort.

DESIGN

In 1997, 35,329 cancer-free women completed a self-administered questionnaire that solicited information on multivitamin use as well as other breast cancer risk factors. Relative risks (RRs) and 95% CIs were calculated by using Cox proportional hazard models and adjusted for breast cancer risk factors.

RESULTS

During a mean follow-up of 9.5 y, 974 women were diagnosed with incident breast cancer. Multivitamin use was associated with a statistically significant increased risk of breast cancer. The multivariable RR of women who reported the use of multivitamins was 1.19 (95% CI: 1.04, 1.37). The association did not differ significantly by hormone receptor status of the breast tumor.

CONCLUSIONS

These results suggest that multivitamin use is associated with an increased risk of breast cancer. This observed association is of concern and merits further investigation.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20335555

Citation

Larsson, Susanna C., et al. "Multivitamin Use and Breast Cancer Incidence in a Prospective Cohort of Swedish Women." The American Journal of Clinical Nutrition, vol. 91, no. 5, 2010, pp. 1268-72.
Larsson SC, Akesson A, Bergkvist L, et al. Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women. Am J Clin Nutr. 2010;91(5):1268-72.
Larsson, S. C., Akesson, A., Bergkvist, L., & Wolk, A. (2010). Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women. The American Journal of Clinical Nutrition, 91(5), 1268-72. https://doi.org/10.3945/ajcn.2009.28837
Larsson SC, et al. Multivitamin Use and Breast Cancer Incidence in a Prospective Cohort of Swedish Women. Am J Clin Nutr. 2010;91(5):1268-72. PubMed PMID: 20335555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women. AU - Larsson,Susanna C, AU - Akesson,Agneta, AU - Bergkvist,Leif, AU - Wolk,Alicja, Y1 - 2010/03/24/ PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/5/29/medline SP - 1268 EP - 72 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 91 IS - 5 N2 - BACKGROUND: Many women use multivitamins in the belief that these supplements will prevent chronic diseases such as cancer and cardiovascular disease. However, whether the use of multivitamins affects the risk of breast cancer is unclear. OBJECTIVE: We prospectively examined the association between multivitamin use and the incidence of invasive breast cancer in the Swedish Mammography Cohort. DESIGN: In 1997, 35,329 cancer-free women completed a self-administered questionnaire that solicited information on multivitamin use as well as other breast cancer risk factors. Relative risks (RRs) and 95% CIs were calculated by using Cox proportional hazard models and adjusted for breast cancer risk factors. RESULTS: During a mean follow-up of 9.5 y, 974 women were diagnosed with incident breast cancer. Multivitamin use was associated with a statistically significant increased risk of breast cancer. The multivariable RR of women who reported the use of multivitamins was 1.19 (95% CI: 1.04, 1.37). The association did not differ significantly by hormone receptor status of the breast tumor. CONCLUSIONS: These results suggest that multivitamin use is associated with an increased risk of breast cancer. This observed association is of concern and merits further investigation. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20335555/Multivitamin_use_and_breast_cancer_incidence_in_a_prospective_cohort_of_Swedish_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28837 DB - PRIME DP - Unbound Medicine ER -