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Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake.
J Nutr. 2010 May; 140(5):1023-8.JN

Abstract

We assessed the dose-response relations within a low range of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and fish intake on fatal coronary heart disease (CHD) and nonfatal myocardial infarction (MI). In a Dutch population-based cohort study, EPA+DHA and fish intake were assessed at baseline among 21,342 participants aged 20-65 y with no history of MI or stroke. Hazard ratios were calculated with Cox proportional-hazard models. During 9-14 y of follow-up (mean 11.3 y), 647 participants (3%) died, of which 82 of CHD. Fatal CHD mainly comprised MI (64 cases). In total, 252 participants survived an MI. Median intakes in quartiles of EPA+DHA were 40, 84, 151, and 234 mg/d. Medians of fish consumption in quartiles were 1.1, 4.2, 10.7, and 17.3 g/d. Compared with the lowest quartile of EPA+DHA, participants in the top quartile had a 49% lower risk of fatal CHD (95% CI: 6-73%) and a 62% lower risk of fatal MI (95% CI: 23-81%). We observed inverse dose-response relations for EPA+DHA intake and fatal CHD (P-trend = 0.05) and fatal MI (P-trend = 0.01). Results were similar for fish consumption. Nonfatal MI was not associated with EPA+DHA or fish intake. In conclusion, in populations with a low fish consumption, EPA+DHA and fish may lower fatal CHD and MI risk in a dose-responsive manner. Low intakes of EPA+DHA or fish do not seem to protect against nonfatal MI.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, 6700 EV, Wageningen, The Netherlands. janette.degoede@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20335635

Citation

de Goede, Janette, et al. "Marine (n-3) Fatty Acids, Fish Consumption, and the 10-year Risk of Fatal and Nonfatal Coronary Heart Disease in a Large Population of Dutch Adults With Low Fish Intake." The Journal of Nutrition, vol. 140, no. 5, 2010, pp. 1023-8.
de Goede J, Geleijnse JM, Boer JM, et al. Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. J Nutr. 2010;140(5):1023-8.
de Goede, J., Geleijnse, J. M., Boer, J. M., Kromhout, D., & Verschuren, W. M. (2010). Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. The Journal of Nutrition, 140(5), 1023-8. https://doi.org/10.3945/jn.109.119271
de Goede J, et al. Marine (n-3) Fatty Acids, Fish Consumption, and the 10-year Risk of Fatal and Nonfatal Coronary Heart Disease in a Large Population of Dutch Adults With Low Fish Intake. J Nutr. 2010;140(5):1023-8. PubMed PMID: 20335635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. AU - de Goede,Janette, AU - Geleijnse,Johanna M, AU - Boer,Jolanda M A, AU - Kromhout,Daan, AU - Verschuren,W M Monique, Y1 - 2010/03/24/ PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/5/5/medline SP - 1023 EP - 8 JF - The Journal of nutrition JO - J. Nutr. VL - 140 IS - 5 N2 - We assessed the dose-response relations within a low range of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and fish intake on fatal coronary heart disease (CHD) and nonfatal myocardial infarction (MI). In a Dutch population-based cohort study, EPA+DHA and fish intake were assessed at baseline among 21,342 participants aged 20-65 y with no history of MI or stroke. Hazard ratios were calculated with Cox proportional-hazard models. During 9-14 y of follow-up (mean 11.3 y), 647 participants (3%) died, of which 82 of CHD. Fatal CHD mainly comprised MI (64 cases). In total, 252 participants survived an MI. Median intakes in quartiles of EPA+DHA were 40, 84, 151, and 234 mg/d. Medians of fish consumption in quartiles were 1.1, 4.2, 10.7, and 17.3 g/d. Compared with the lowest quartile of EPA+DHA, participants in the top quartile had a 49% lower risk of fatal CHD (95% CI: 6-73%) and a 62% lower risk of fatal MI (95% CI: 23-81%). We observed inverse dose-response relations for EPA+DHA intake and fatal CHD (P-trend = 0.05) and fatal MI (P-trend = 0.01). Results were similar for fish consumption. Nonfatal MI was not associated with EPA+DHA or fish intake. In conclusion, in populations with a low fish consumption, EPA+DHA and fish may lower fatal CHD and MI risk in a dose-responsive manner. Low intakes of EPA+DHA or fish do not seem to protect against nonfatal MI. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20335635/Marine__n_3__fatty_acids_fish_consumption_and_the_10_year_risk_of_fatal_and_nonfatal_coronary_heart_disease_in_a_large_population_of_Dutch_adults_with_low_fish_intake_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.119271 DB - PRIME DP - Unbound Medicine ER -