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Gender differences in serum leptin concentrations from umbilical cord blood of newborn infants born to nondiabetic, gestational diabetic and type-2 diabetic mothers.
Int J Diabetes Dev Ctries 2009; 29(4):155-8IJ

Abstract

To investigate gender differences, if any, in leptin concentrations from umbilical cord blood of new born infants of mothers with type 2 diabetes mellitus (DM), gestational diabetes mellitus (GDM), and Non diabetic (ND) at delivery. Serum leptin concentrations were measured in 105 newborns (53 males and 52 females in the three groups). Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded within 48 hours after delivery. Pearson correlation coefficient was used to explore the relationship between serum leptin concentrations and anthropometric measures of the fetus and their mother. Both Serum leptin level and serum C-peptide was measured by chemiluminescence based ELISA. The median range of leptin concentration in cord blood was ND group: Male [13.91 (3.22 - 47.63)], Female [16.88 (2 - 43.65)]; GDM group: Male [32 (7 - 76.00)], Female [36.73 (4.80 - 81.20)]; DM group: Male [20.90 (2 -76.00)], Female [32 {2.58 - 80.67)]. Cord serum leptin levels correlated with birth weight(r=0.587, p=0.0001), ponderal index (PI) (r=.319, p=0.024)of the babies and body mass index (BMI) (r=-0.299, p=0.035) of their mothers but did not correlate with gestational age, cord serum C-peptide concentration or placental weight at delivery. Leptin concentrations were higher in the female fetus in comparison to the male fetus. Birth weight of the female fetuses were also higher than that of male fetus. We found that there are very strong associations between cord leptin concentrations at delivery and birth weight, ponderal index of the baby, body mass index of the mothers with Type 2 DM. We also found that high leptin levels could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation or adipose tissue is the major determinant of circulating leptin levels.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20336197

Citation

Jahan, Samsad, et al. "Gender Differences in Serum Leptin Concentrations From Umbilical Cord Blood of Newborn Infants Born to Nondiabetic, Gestational Diabetic and Type-2 Diabetic Mothers." International Journal of Diabetes in Developing Countries, vol. 29, no. 4, 2009, pp. 155-8.
Jahan S, Zinnat R, Hassan Z, et al. Gender differences in serum leptin concentrations from umbilical cord blood of newborn infants born to nondiabetic, gestational diabetic and type-2 diabetic mothers. Int J Diabetes Dev Ctries. 2009;29(4):155-8.
Jahan, S., Zinnat, R., Hassan, Z., Biswas, K. B., & Habib, S. H. (2009). Gender differences in serum leptin concentrations from umbilical cord blood of newborn infants born to nondiabetic, gestational diabetic and type-2 diabetic mothers. International Journal of Diabetes in Developing Countries, 29(4), pp. 155-8. doi:10.4103/0973-3930.57346.
Jahan S, et al. Gender Differences in Serum Leptin Concentrations From Umbilical Cord Blood of Newborn Infants Born to Nondiabetic, Gestational Diabetic and Type-2 Diabetic Mothers. Int J Diabetes Dev Ctries. 2009;29(4):155-8. PubMed PMID: 20336197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender differences in serum leptin concentrations from umbilical cord blood of newborn infants born to nondiabetic, gestational diabetic and type-2 diabetic mothers. AU - Jahan,Samsad, AU - Zinnat,Rahelee, AU - Hassan,Zahid, AU - Biswas,Kazal Boron, AU - Habib,Samira Humaira, PY - 2008/07/08/received PY - 2009/09/12/accepted PY - 2010/3/26/entrez PY - 2010/3/26/pubmed PY - 2010/3/26/medline KW - Newborn infants KW - Serum leptin KW - Type 2 Diabetic KW - Umbilical cord blood KW - gestational diabetes mellitus KW - non diabetic SP - 155 EP - 8 JF - International journal of diabetes in developing countries JO - Int J Diabetes Dev Ctries VL - 29 IS - 4 N2 - To investigate gender differences, if any, in leptin concentrations from umbilical cord blood of new born infants of mothers with type 2 diabetes mellitus (DM), gestational diabetes mellitus (GDM), and Non diabetic (ND) at delivery. Serum leptin concentrations were measured in 105 newborns (53 males and 52 females in the three groups). Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded within 48 hours after delivery. Pearson correlation coefficient was used to explore the relationship between serum leptin concentrations and anthropometric measures of the fetus and their mother. Both Serum leptin level and serum C-peptide was measured by chemiluminescence based ELISA. The median range of leptin concentration in cord blood was ND group: Male [13.91 (3.22 - 47.63)], Female [16.88 (2 - 43.65)]; GDM group: Male [32 (7 - 76.00)], Female [36.73 (4.80 - 81.20)]; DM group: Male [20.90 (2 -76.00)], Female [32 {2.58 - 80.67)]. Cord serum leptin levels correlated with birth weight(r=0.587, p=0.0001), ponderal index (PI) (r=.319, p=0.024)of the babies and body mass index (BMI) (r=-0.299, p=0.035) of their mothers but did not correlate with gestational age, cord serum C-peptide concentration or placental weight at delivery. Leptin concentrations were higher in the female fetus in comparison to the male fetus. Birth weight of the female fetuses were also higher than that of male fetus. We found that there are very strong associations between cord leptin concentrations at delivery and birth weight, ponderal index of the baby, body mass index of the mothers with Type 2 DM. We also found that high leptin levels could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation or adipose tissue is the major determinant of circulating leptin levels. SN - 1998-3832 UR - https://www.unboundmedicine.com/medline/citation/20336197/Gender_differences_in_serum_leptin_concentrations_from_umbilical_cord_blood_of_newborn_infants_born_to_nondiabetic_gestational_diabetic_and_type_2_diabetic_mothers_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20336197/ DB - PRIME DP - Unbound Medicine ER -