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Tandem reactions of N'-(2-alkynylbenzylidene)hydrazides with silyl enolates: a facile route to H-pyrazolo[5,1-a]isoquinolines.
J Comb Chem. 2010 May 10; 12(3):374-8.JC

Abstract

A silver triflate-catalyzed tandem reaction of N'-(2-alkynylbenzylidene)hydrazide with silyl enolate is described, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good to excellent yields. Intramolecular cyclization, nucleophilic addition, condensation, and aromatization may be involved in the reaction process.

Authors+Show Affiliations

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20337469

Citation

Yu, Xingxin, et al. "Tandem Reactions of N'-(2-alkynylbenzylidene)hydrazides With Silyl Enolates: a Facile Route to H-pyrazolo[5,1-a]isoquinolines." Journal of Combinatorial Chemistry, vol. 12, no. 3, 2010, pp. 374-8.
Yu X, Chen Z, Yang X, et al. Tandem reactions of N'-(2-alkynylbenzylidene)hydrazides with silyl enolates: a facile route to H-pyrazolo[5,1-a]isoquinolines. J Comb Chem. 2010;12(3):374-8.
Yu, X., Chen, Z., Yang, X., & Wu, J. (2010). Tandem reactions of N'-(2-alkynylbenzylidene)hydrazides with silyl enolates: a facile route to H-pyrazolo[5,1-a]isoquinolines. Journal of Combinatorial Chemistry, 12(3), 374-8. https://doi.org/10.1021/cc1000314
Yu X, et al. Tandem Reactions of N'-(2-alkynylbenzylidene)hydrazides With Silyl Enolates: a Facile Route to H-pyrazolo[5,1-a]isoquinolines. J Comb Chem. 2010 May 10;12(3):374-8. PubMed PMID: 20337469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tandem reactions of N'-(2-alkynylbenzylidene)hydrazides with silyl enolates: a facile route to H-pyrazolo[5,1-a]isoquinolines. AU - Yu,Xingxin, AU - Chen,Zhiyuan, AU - Yang,Xiaodi, AU - Wu,Jie, PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2010/10/12/medline SP - 374 EP - 8 JF - Journal of combinatorial chemistry JO - J Comb Chem VL - 12 IS - 3 N2 - A silver triflate-catalyzed tandem reaction of N'-(2-alkynylbenzylidene)hydrazide with silyl enolate is described, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good to excellent yields. Intramolecular cyclization, nucleophilic addition, condensation, and aromatization may be involved in the reaction process. SN - 1520-4774 UR - https://www.unboundmedicine.com/medline/citation/20337469/Tandem_reactions_of_N'__2_alkynylbenzylidene_hydrazides_with_silyl_enolates:_a_facile_route_to_H_pyrazolo[51_a]isoquinolines_ L2 - https://doi.org/10.1021/cc1000314 DB - PRIME DP - Unbound Medicine ER -