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The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis.
J Periodontal Res. 2010 Jun; 45(3):396-403.JP

Abstract

BACKGROUND AND OBJECTIVE

Periodontitis is influenced by specific host-dependent immune responses. Periodontopathogens induce innate immune responses, amongst others, via toll-like receptor 2 (TLR2), resulting in activation of the nuclear transcription factor nuclear factor-kappaB (NF-kappaB). The aim of this case-control study was to evaluate links between genetic variants of these genes and chronic/aggressive periodontitis in a multivariate model.

MATERIAL AND METHODS

A total of 141 patients with periodontitis (63 with chronic periodontitis and 78 with aggressive periodontitis) and 81 controls without periodontitis were included in the study. Polymorphisms in TLR2 (Arg677Trp, Arg753Gln) and in NF-kappaB (-94ins/delATTG) were determined by restriction fragment length polymorphism and fragment length analyses, respectively. Subgingival bacterial colonization was evaluated using a PCR/DNA probe test (micro-Ident).

RESULTS

Although there was no association of the TLR2 polymorphism Arg753Gln with periodontitis, heterozygous carriers (Arg/Gln) were at a higher risk for colonization with bacteria of the 'red complex' (corrected p-value = 0.042). The del/del genotype of the NF-kappaB polymorphism was associated with aggressive periodontitis considering age, gender, smoking and approximal plaque index as potential confounders (odds ratio = 2.81, p = 0.035, 95% confidence interval: 1.08-7.33). del/del carriers had a higher risk for subgingival colonization with Aggregatibacter actinomycetemcomitans (odds ratio = 2.36, p = 0.030, 95% confidence interval: 1.09-5.1; adjusted for age, gender, smoking and pocket depth(bacteria)).

CONCLUSIONS

The del/del genotype of NF-kappaB was shown to be associated with the occurrence of aggressive periodontitis.

Authors+Show Affiliations

Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Martin-Luther University Halle-Wittenberg, Halle, Germany. susanne.schulz@medizin.uni-halle.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20337891

Citation

Schulz, S, et al. "The Del/del Genotype of the Nuclear factor-kappaB -94ATTG Polymorphism and Its Relation to Aggressive Periodontitis." Journal of Periodontal Research, vol. 45, no. 3, 2010, pp. 396-403.
Schulz S, Hierse L, Altermann W, et al. The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis. J Periodontal Res. 2010;45(3):396-403.
Schulz, S., Hierse, L., Altermann, W., Klapproth, J., Zimmermann, U., Reichert, Y., Gläser, C., Kluttig, A., Stein, J. M., Schaller, H. G., & Reichert, S. (2010). The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis. Journal of Periodontal Research, 45(3), 396-403. https://doi.org/10.1111/j.1600-0765.2009.01251.x
Schulz S, et al. The Del/del Genotype of the Nuclear factor-kappaB -94ATTG Polymorphism and Its Relation to Aggressive Periodontitis. J Periodontal Res. 2010;45(3):396-403. PubMed PMID: 20337891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis. AU - Schulz,S, AU - Hierse,L, AU - Altermann,W, AU - Klapproth,J, AU - Zimmermann,U, AU - Reichert,Y, AU - Gläser,C, AU - Kluttig,A, AU - Stein,J M, AU - Schaller,H-G, AU - Reichert,S, Y1 - 2010/03/09/ PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2010/9/30/medline SP - 396 EP - 403 JF - Journal of periodontal research JO - J Periodontal Res VL - 45 IS - 3 N2 - BACKGROUND AND OBJECTIVE: Periodontitis is influenced by specific host-dependent immune responses. Periodontopathogens induce innate immune responses, amongst others, via toll-like receptor 2 (TLR2), resulting in activation of the nuclear transcription factor nuclear factor-kappaB (NF-kappaB). The aim of this case-control study was to evaluate links between genetic variants of these genes and chronic/aggressive periodontitis in a multivariate model. MATERIAL AND METHODS: A total of 141 patients with periodontitis (63 with chronic periodontitis and 78 with aggressive periodontitis) and 81 controls without periodontitis were included in the study. Polymorphisms in TLR2 (Arg677Trp, Arg753Gln) and in NF-kappaB (-94ins/delATTG) were determined by restriction fragment length polymorphism and fragment length analyses, respectively. Subgingival bacterial colonization was evaluated using a PCR/DNA probe test (micro-Ident). RESULTS: Although there was no association of the TLR2 polymorphism Arg753Gln with periodontitis, heterozygous carriers (Arg/Gln) were at a higher risk for colonization with bacteria of the 'red complex' (corrected p-value = 0.042). The del/del genotype of the NF-kappaB polymorphism was associated with aggressive periodontitis considering age, gender, smoking and approximal plaque index as potential confounders (odds ratio = 2.81, p = 0.035, 95% confidence interval: 1.08-7.33). del/del carriers had a higher risk for subgingival colonization with Aggregatibacter actinomycetemcomitans (odds ratio = 2.36, p = 0.030, 95% confidence interval: 1.09-5.1; adjusted for age, gender, smoking and pocket depth(bacteria)). CONCLUSIONS: The del/del genotype of NF-kappaB was shown to be associated with the occurrence of aggressive periodontitis. SN - 1600-0765 UR - https://www.unboundmedicine.com/medline/citation/20337891/The_del/del_genotype_of_the_nuclear_factor_kappaB__94ATTG_polymorphism_and_its_relation_to_aggressive_periodontitis_ L2 - https://doi.org/10.1111/j.1600-0765.2009.01251.x DB - PRIME DP - Unbound Medicine ER -