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The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy.
Pediatr Allergy Immunol 2010; 21(4 Pt 1):577-85PA

Abstract

Infants diagnosed with allergy to cow's milk protein (CMP) are fed extensively hydrolysed cow's milk formulas, modified soy formulas or even amino acid-based formulas. Hydrolysed rice protein infant formulas have become available and have been shown to be well tolerated by these infants. A prospective open, randomized clinical study to compare the clinical tolerance of a new hydrolysed rice protein formula (HRPF) with an extensively hydrolysed CMP formula (EHF) in the feeding of infants with IgE-mediated cow's milk allergy. Ninety-two infants (46 boys and 46 girls, mean age 4.3 months, range 1.1-10.1 months) diagnosed with IgE-mediated cow's milk allergy were enrolled in the study. Clinical tolerance to the formula products was tested. Clinical evaluation included skin prick tests with whole cow's milk, soya and rice as well as antigens of CMP (beta-lactoglobulin, alpha-lactalbumin, casein and bovine seroalbumin), HRPF and EHF and specific IgE determinations to CMP using CAP technology. Patients were randomized to receive either an EHF based on CMP or a new HRPF. Follow-up was at 3, 6, 12, 18 and 24 months. Growth parameters were measured at each visit. One infant showed immediate allergic reaction to EHF, but no reaction was shown by any infant in the HRPF group. The number of infants who did not become tolerant to CMP during the study was not statistically different between the two groups. Measurement of IgE levels of infants allergic to CMP during the study showed no significant differences between the two formula groups. Growth parameters were in the normal range and similar between groups. In this study, the HRPF was well tolerated by infants with moderate to severe symptoms of IgE-mediated CMP allergy. Children receiving this formula showed similar growth and development of clinical tolerance to those receiving an EHF. In accordance with current guidelines, this HRPF was tolerated by more than 90% of children with CMP allergy and therefore could provide an adequate and safe alternative to CMP-hydrolysed formulas for these infants.

Authors+Show Affiliations

Allergy Department, University Children's Hospital La Paz, Madrid, Spain. martareche@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20337976

Citation

Reche, M, et al. "The Effect of a Partially Hydrolysed Formula Based On Rice Protein in the Treatment of Infants With Cow's Milk Protein Allergy." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 21, no. 4 Pt 1, 2010, pp. 577-85.
Reche M, Pascual C, Fiandor A, et al. The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy. Pediatr Allergy Immunol. 2010;21(4 Pt 1):577-85.
Reche, M., Pascual, C., Fiandor, A., Polanco, I., Rivero-Urgell, M., Chifre, R., ... Martín-Esteban, M. (2010). The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 21(4 Pt 1), pp. 577-85. doi:10.1111/j.1399-3038.2010.00991.x.
Reche M, et al. The Effect of a Partially Hydrolysed Formula Based On Rice Protein in the Treatment of Infants With Cow's Milk Protein Allergy. Pediatr Allergy Immunol. 2010;21(4 Pt 1):577-85. PubMed PMID: 20337976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy. AU - Reche,M, AU - Pascual,C, AU - Fiandor,A, AU - Polanco,I, AU - Rivero-Urgell,M, AU - Chifre,R, AU - Johnston,S, AU - Martín-Esteban,M, Y1 - 2010/03/10/ PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2011/2/26/medline SP - 577 EP - 85 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 21 IS - 4 Pt 1 N2 - Infants diagnosed with allergy to cow's milk protein (CMP) are fed extensively hydrolysed cow's milk formulas, modified soy formulas or even amino acid-based formulas. Hydrolysed rice protein infant formulas have become available and have been shown to be well tolerated by these infants. A prospective open, randomized clinical study to compare the clinical tolerance of a new hydrolysed rice protein formula (HRPF) with an extensively hydrolysed CMP formula (EHF) in the feeding of infants with IgE-mediated cow's milk allergy. Ninety-two infants (46 boys and 46 girls, mean age 4.3 months, range 1.1-10.1 months) diagnosed with IgE-mediated cow's milk allergy were enrolled in the study. Clinical tolerance to the formula products was tested. Clinical evaluation included skin prick tests with whole cow's milk, soya and rice as well as antigens of CMP (beta-lactoglobulin, alpha-lactalbumin, casein and bovine seroalbumin), HRPF and EHF and specific IgE determinations to CMP using CAP technology. Patients were randomized to receive either an EHF based on CMP or a new HRPF. Follow-up was at 3, 6, 12, 18 and 24 months. Growth parameters were measured at each visit. One infant showed immediate allergic reaction to EHF, but no reaction was shown by any infant in the HRPF group. The number of infants who did not become tolerant to CMP during the study was not statistically different between the two groups. Measurement of IgE levels of infants allergic to CMP during the study showed no significant differences between the two formula groups. Growth parameters were in the normal range and similar between groups. In this study, the HRPF was well tolerated by infants with moderate to severe symptoms of IgE-mediated CMP allergy. Children receiving this formula showed similar growth and development of clinical tolerance to those receiving an EHF. In accordance with current guidelines, this HRPF was tolerated by more than 90% of children with CMP allergy and therefore could provide an adequate and safe alternative to CMP-hydrolysed formulas for these infants. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/20337976/The_effect_of_a_partially_hydrolysed_formula_based_on_rice_protein_in_the_treatment_of_infants_with_cow's_milk_protein_allergy_ L2 - https://doi.org/10.1111/j.1399-3038.2010.00991.x DB - PRIME DP - Unbound Medicine ER -