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Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan.

Abstract

Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case-control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0.87, 0.70 and 0.11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0.56 (0.33, 0.94), 0.69 (0.38, 1.25) and 0.48 (0.23, 0.99), respectively (P for trend = 0.10). In conclusion, in the present case-control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD.

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  • Authors+Show Affiliations

    ,

    Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. kenmrkm@m.u-tokyo.ac.jp

    , , , , , , , , , , , , , ,

    Source

    The British journal of nutrition 104:5 2010 Sep pg 757-64

    MeSH

    Aged
    Case-Control Studies
    Diet
    Diet Surveys
    Female
    Folic Acid
    Humans
    Japan
    Male
    Middle Aged
    Odds Ratio
    Parkinson Disease
    Riboflavin
    Risk Factors
    Surveys and Questionnaires
    Vitamin B 12
    Vitamin B 6
    Vitamin B Complex

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20338075

    Citation

    Murakami, Kentaro, et al. "Dietary Intake of Folate, Vitamin B6, Vitamin B12 and Riboflavin and Risk of Parkinson's Disease: a Case-control Study in Japan." The British Journal of Nutrition, vol. 104, no. 5, 2010, pp. 757-64.
    Murakami K, Miyake Y, Sasaki S, et al. Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan. Br J Nutr. 2010;104(5):757-64.
    Murakami, K., Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., ... Nagai, M. (2010). Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan. The British Journal of Nutrition, 104(5), pp. 757-64. doi:10.1017/S0007114510001005.
    Murakami K, et al. Dietary Intake of Folate, Vitamin B6, Vitamin B12 and Riboflavin and Risk of Parkinson's Disease: a Case-control Study in Japan. Br J Nutr. 2010;104(5):757-64. PubMed PMID: 20338075.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan. AU - Murakami,Kentaro, AU - Miyake,Yoshihiro, AU - Sasaki,Satoshi, AU - Tanaka,Keiko, AU - Fukushima,Wakaba, AU - Kiyohara,Chikako, AU - Tsuboi,Yoshio, AU - Yamada,Tatsuo, AU - Oeda,Tomoko, AU - Miki,Takami, AU - Kawamura,Nobutoshi, AU - Sakae,Nobutaka, AU - Fukuyama,Hidenao, AU - Hirota,Yoshio, AU - Nagai,Masaki, AU - ,, Y1 - 2010/03/26/ PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2010/9/24/medline SP - 757 EP - 64 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 104 IS - 5 N2 - Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved in the regulation of homocysteine metabolism might decrease the risk of PD through decreasing plasma homocysteine. However, epidemiological evidence for the association of dietary B vitamins with PD is sparse, particularly in non-Western populations. We conducted a hospital-based case-control study in Japan to examine associations between dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and the risk of PD. Patients with PD diagnosed using the UK PD Society Brain Bank criteria (n 249) and controls without neurodegenerative diseases (n 368) were recruited. Dietary intake during the preceding month was assessed at the time of study recruitment using a validated, self-administered, semi-quantitative, comprehensive diet history questionnaire. After adjustment for potential dietary and non-dietary confounding factors, intake of folate, vitamin B12 and riboflavin was not associated with the risk of PD (P for trend = 0.87, 0.70 and 0.11, respectively). However, low intake of vitamin B6 was associated with an increased risk of PD, independent of potential dietary and non-dietary confounders. Multivariate OR (95 % CI) for PD in the first, second, third and fourth quartiles of vitamin B6 were 1 (reference), 0.56 (0.33, 0.94), 0.69 (0.38, 1.25) and 0.48 (0.23, 0.99), respectively (P for trend = 0.10). In conclusion, in the present case-control study in Japan, low intake of vitamin B6, but not of folate, vitamin B12 or riboflavin, was independently associated with an increased risk of PD. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/20338075/Dietary_intake_of_folate_vitamin_B6_vitamin_B12_and_riboflavin_and_risk_of_Parkinson's_disease:_a_case_control_study_in_Japan_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510001005/type/journal_article DB - PRIME DP - Unbound Medicine ER -