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Chitosomes as drug delivery systems for C-phycocyanin: preparation and characterization.
Int J Pharm. 2010 Jun 15; 392(1-2):92-100.IJ

Abstract

The aim of this work was to investigate chitosomes, i.e. liposomes coated by a polyelectrolyte complex between chitosan (CH) and xantan gum (XG), as potential delivery system for oral administration of the protein C-phycocyanin. To this purpose several CH-XG-microcomplexes were prepared in aqueous lactic acid at different chitosan-xanthan gum percent ratios and rheological properties of the microcomplexes were studied to analyse the contribution of chitosan and xanthan gum in the reaction of microcomplexation. After establishing the best microcomplexes, chitosomes were prepared by coating C-phycocyanin loaded liposomes with the CH-XG hydrogels using spray-drying or freeze-drying. The chitosomes were characterized in terms of morphology, size distribution, zeta potential, swelling properties, drug release, and mucoadhesive properties. Rheological studies showed the influence of xanthan gum in the microcomplex properties. Moreover, obtained results demonstrated the effects of formulation and process variables on particle size, drug content, swelling, drug release, and especially on the mucoadhesiveness of C-PC chitosomes of CH-XG. In particular, chitosomes prepared by spray-drying technique using CH-XG in 0.5/8.0 (w/w) ratio showed a regular surface and a drug release characteristic for a Fickian diffusion of the active ingredient. The in vitro mucoadhesive study revealed that the spray-drying method is advantageous to prepare C-phycocyanin loaded chitosomes with excellent mucoadhesive properties for colonic drug delivery.

Authors+Show Affiliations

Dipartamento Farmaco Chimico Tecnologico, Universita'degli Studi di Cagliari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20338230

Citation

Manconi, M, et al. "Chitosomes as Drug Delivery Systems for C-phycocyanin: Preparation and Characterization." International Journal of Pharmaceutics, vol. 392, no. 1-2, 2010, pp. 92-100.
Manconi M, Mura S, Manca ML, et al. Chitosomes as drug delivery systems for C-phycocyanin: preparation and characterization. Int J Pharm. 2010;392(1-2):92-100.
Manconi, M., Mura, S., Manca, M. L., Fadda, A. M., Dolz, M., Hernandez, M. J., Casanovas, A., & Díez-Sales, O. (2010). Chitosomes as drug delivery systems for C-phycocyanin: preparation and characterization. International Journal of Pharmaceutics, 392(1-2), 92-100. https://doi.org/10.1016/j.ijpharm.2010.03.038
Manconi M, et al. Chitosomes as Drug Delivery Systems for C-phycocyanin: Preparation and Characterization. Int J Pharm. 2010 Jun 15;392(1-2):92-100. PubMed PMID: 20338230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitosomes as drug delivery systems for C-phycocyanin: preparation and characterization. AU - Manconi,M, AU - Mura,S, AU - Manca,M L, AU - Fadda,A M, AU - Dolz,M, AU - Hernandez,M J, AU - Casanovas,A, AU - Díez-Sales,O, Y1 - 2010/03/23/ PY - 2009/12/14/received PY - 2010/03/13/accepted PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2010/9/8/medline SP - 92 EP - 100 JF - International journal of pharmaceutics JO - Int J Pharm VL - 392 IS - 1-2 N2 - The aim of this work was to investigate chitosomes, i.e. liposomes coated by a polyelectrolyte complex between chitosan (CH) and xantan gum (XG), as potential delivery system for oral administration of the protein C-phycocyanin. To this purpose several CH-XG-microcomplexes were prepared in aqueous lactic acid at different chitosan-xanthan gum percent ratios and rheological properties of the microcomplexes were studied to analyse the contribution of chitosan and xanthan gum in the reaction of microcomplexation. After establishing the best microcomplexes, chitosomes were prepared by coating C-phycocyanin loaded liposomes with the CH-XG hydrogels using spray-drying or freeze-drying. The chitosomes were characterized in terms of morphology, size distribution, zeta potential, swelling properties, drug release, and mucoadhesive properties. Rheological studies showed the influence of xanthan gum in the microcomplex properties. Moreover, obtained results demonstrated the effects of formulation and process variables on particle size, drug content, swelling, drug release, and especially on the mucoadhesiveness of C-PC chitosomes of CH-XG. In particular, chitosomes prepared by spray-drying technique using CH-XG in 0.5/8.0 (w/w) ratio showed a regular surface and a drug release characteristic for a Fickian diffusion of the active ingredient. The in vitro mucoadhesive study revealed that the spray-drying method is advantageous to prepare C-phycocyanin loaded chitosomes with excellent mucoadhesive properties for colonic drug delivery. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/20338230/Chitosomes_as_drug_delivery_systems_for_C_phycocyanin:_preparation_and_characterization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(10)00212-7 DB - PRIME DP - Unbound Medicine ER -