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Chosen factors of T and B cell apoptosis in hypertrophic adenoid in children with otitis media with effusion.
Int J Pediatr Otorhinolaryngol. 2010 Jun; 74(6):698-700.IJ

Abstract

Evaluation of lymphocyte homeostasis within the chronically inflamed adenoid, closely related to the functioning of the immune system, may have a role in qualifying children for adenoidectomy. Apoptosis is a major process maintaining balance between tonsillar lymphocytes. The Fas receptor and Bcl-2 protein family which show pro-apoptotic and anti-apoptotic actions are of particular significance in apoptosis induction. Adenoid excised due to hypertrophy with or without chronic otitis media with effusion was used as study material. Flow cytometry was used to assess the percentages of apoptotic lymphocytes and CD4(+), CD8(+), CD19(+) cells with CD95(+) antigen and Bcl-2 protein in the group of children who underwent adenoidectomy due to adenoid hypertrophy and accompanying otitis media with effusion. The percentages of CD4(+)Bcl-2(+), CD8(+)Bcl-2(+) and CD19(+)Bcl-2(+) lymphocytes in the group of children with adenoid hypertrophy and acute otitis media were lower as compared to the reference group. However, the percentages of CD4(+), CD8(+) and CD19(+) cells with CD95(+) antigen were higher in the study group comparing to the reference group. The tendency of reduced percentages of T and B lymphocytes with Bcl-2 expression and elevated percentages of these cells with CD95(+) expression within the adenoid may reflect local immunity disorders.

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Authors+Show Affiliations

Zelazowska-Rutkowska B
Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 17, 15-274 Białystok, Poland. zelazowskab@wp.pl
Wysocka J
No affiliation info available
Skotnicka B
No affiliation info available

MeSH

AdenoidectomyAdenoidsAdolescentAntigens, CDApoptosisB-LymphocytesChildChild, PreschoolFlow CytometryHomeostasisHumansHypertrophyInfantOtitis Media with EffusionPalatine TonsilT-Lymphocytes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20338643

Citation

Zelazowska-Rutkowska, Beata, et al. "Chosen Factors of T and B Cell Apoptosis in Hypertrophic Adenoid in Children With Otitis Media With Effusion." International Journal of Pediatric Otorhinolaryngology, vol. 74, no. 6, 2010, pp. 698-700.
Zelazowska-Rutkowska B, Wysocka J, Skotnicka B. Chosen factors of T and B cell apoptosis in hypertrophic adenoid in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2010;74(6):698-700.
Zelazowska-Rutkowska, B., Wysocka, J., & Skotnicka, B. (2010). Chosen factors of T and B cell apoptosis in hypertrophic adenoid in children with otitis media with effusion. International Journal of Pediatric Otorhinolaryngology, 74(6), 698-700. https://doi.org/10.1016/j.ijporl.2010.02.024
Zelazowska-Rutkowska B, Wysocka J, Skotnicka B. Chosen Factors of T and B Cell Apoptosis in Hypertrophic Adenoid in Children With Otitis Media With Effusion. Int J Pediatr Otorhinolaryngol. 2010;74(6):698-700. PubMed PMID: 20338643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chosen factors of T and B cell apoptosis in hypertrophic adenoid in children with otitis media with effusion. AU - Zelazowska-Rutkowska,Beata, AU - Wysocka,Jolanta, AU - Skotnicka,Bozena, Y1 - 2010/03/24/ PY - 2009/11/08/received PY - 2010/02/15/revised PY - 2010/02/18/accepted PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2010/9/2/medline SP - 698 EP - 700 JF - International journal of pediatric otorhinolaryngology JO - Int J Pediatr Otorhinolaryngol VL - 74 IS - 6 N2 - Evaluation of lymphocyte homeostasis within the chronically inflamed adenoid, closely related to the functioning of the immune system, may have a role in qualifying children for adenoidectomy. Apoptosis is a major process maintaining balance between tonsillar lymphocytes. The Fas receptor and Bcl-2 protein family which show pro-apoptotic and anti-apoptotic actions are of particular significance in apoptosis induction. Adenoid excised due to hypertrophy with or without chronic otitis media with effusion was used as study material. Flow cytometry was used to assess the percentages of apoptotic lymphocytes and CD4(+), CD8(+), CD19(+) cells with CD95(+) antigen and Bcl-2 protein in the group of children who underwent adenoidectomy due to adenoid hypertrophy and accompanying otitis media with effusion. The percentages of CD4(+)Bcl-2(+), CD8(+)Bcl-2(+) and CD19(+)Bcl-2(+) lymphocytes in the group of children with adenoid hypertrophy and acute otitis media were lower as compared to the reference group. However, the percentages of CD4(+), CD8(+) and CD19(+) cells with CD95(+) antigen were higher in the study group comparing to the reference group. The tendency of reduced percentages of T and B lymphocytes with Bcl-2 expression and elevated percentages of these cells with CD95(+) expression within the adenoid may reflect local immunity disorders. SN - 1872-8464 UR - https://www.unboundmedicine.com/medline/citation/20338643/Chosen_factors_of_T_and_B_cell_apoptosis_in_hypertrophic_adenoid_in_children_with_otitis_media_with_effusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(10)00093-5 DB - PRIME DP - Unbound Medicine ER -