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Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes.
Clin J Am Soc Nephrol. 2010 Apr; 5(4):673-82.CJ

Abstract

BACKGROUND AND OBJECTIVES

Prevalence of chronic kidney disease (CKD) in people with diagnosed diabetes is known to be high, but little is known about the prevalence of CKD in those with undiagnosed diabetes or prediabetes. We aimed to estimate and compare the community prevalence of CKD among people with diagnosed diabetes, undiagnosed diabetes, prediabetes, or no diabetes.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

The 1999 through 2006 National Health and Nutrition Examination Survey is a representative survey of the civilian, noninstitutionalized US population. Participants who were aged > or =20 years; responded to the diabetes questionnaire; and had fasting plasma glucose (FPG), serum creatinine, and urinary albumin-creatinine ratio measurements were included (N = 8188). Diabetes status was defined as follows: Diagnosed diabetes, self-reported provider diagnosis (n = 826); undiagnosed diabetes, FPG > or =126 mg/dl without self-reported diagnosis (n = 299); prediabetes, FPG > or =100 and <126 mg/dl (n = 2272); and no diabetes, FPG <100 mg/dl (n = 4791). Prevalence of CKD was defined by estimated GFR 15 to 59 ml/min per 1.73 m(2) or albumin-creatinine ratio > or =30 mg/g; adjustment was performed with multivariable logistic regression.

RESULTS

Fully 39.6% of people with diagnosed and 41.7% with undiagnosed diabetes had CKD; 17.7% with prediabetes and 10.6% without diabetes had CKD. Age-, gender-, and race/ethnicity-adjusted prevalence of CKD was 32.9, 24.2, 17.1, and 11.8%, for diagnosed, undiagnosed, pre-, and no diabetes, respectively. Among those with CKD, 39.1% had undiagnosed or prediabetes.

CONCLUSIONS

CKD prevalence is high among people with undiagnosed diabetes and prediabetes. These individuals might benefit from interventions aimed at preventing development and/or progression of both CKD and diabetes.

Authors+Show Affiliations

San Francisco General Hospital and University of California, San Francisco, 1001 Potrero Avenue, Building 10, Floor 3, San Francisco, CA 94110, USA. plantingal@medsfgh.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20338960

Citation

Plantinga, Laura C., et al. "Prevalence of Chronic Kidney Disease in US Adults With Undiagnosed Diabetes or Prediabetes." Clinical Journal of the American Society of Nephrology : CJASN, vol. 5, no. 4, 2010, pp. 673-82.
Plantinga LC, Crews DC, Coresh J, et al. Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes. Clin J Am Soc Nephrol. 2010;5(4):673-82.
Plantinga, L. C., Crews, D. C., Coresh, J., Miller, E. R., Saran, R., Yee, J., Hedgeman, E., Pavkov, M., Eberhardt, M. S., Williams, D. E., & Powe, N. R. (2010). Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes. Clinical Journal of the American Society of Nephrology : CJASN, 5(4), 673-82. https://doi.org/10.2215/CJN.07891109
Plantinga LC, et al. Prevalence of Chronic Kidney Disease in US Adults With Undiagnosed Diabetes or Prediabetes. Clin J Am Soc Nephrol. 2010;5(4):673-82. PubMed PMID: 20338960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of chronic kidney disease in US adults with undiagnosed diabetes or prediabetes. AU - Plantinga,Laura C, AU - Crews,Deidra C, AU - Coresh,Josef, AU - Miller,Edgar R,3rd AU - Saran,Rajiv, AU - Yee,Jerry, AU - Hedgeman,Elizabeth, AU - Pavkov,Meda, AU - Eberhardt,Mark S, AU - Williams,Desmond E, AU - Powe,Neil R, AU - ,, Y1 - 2010/03/25/ PY - 2010/3/27/entrez PY - 2010/3/27/pubmed PY - 2010/7/7/medline SP - 673 EP - 82 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 5 IS - 4 N2 - BACKGROUND AND OBJECTIVES: Prevalence of chronic kidney disease (CKD) in people with diagnosed diabetes is known to be high, but little is known about the prevalence of CKD in those with undiagnosed diabetes or prediabetes. We aimed to estimate and compare the community prevalence of CKD among people with diagnosed diabetes, undiagnosed diabetes, prediabetes, or no diabetes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The 1999 through 2006 National Health and Nutrition Examination Survey is a representative survey of the civilian, noninstitutionalized US population. Participants who were aged > or =20 years; responded to the diabetes questionnaire; and had fasting plasma glucose (FPG), serum creatinine, and urinary albumin-creatinine ratio measurements were included (N = 8188). Diabetes status was defined as follows: Diagnosed diabetes, self-reported provider diagnosis (n = 826); undiagnosed diabetes, FPG > or =126 mg/dl without self-reported diagnosis (n = 299); prediabetes, FPG > or =100 and <126 mg/dl (n = 2272); and no diabetes, FPG <100 mg/dl (n = 4791). Prevalence of CKD was defined by estimated GFR 15 to 59 ml/min per 1.73 m(2) or albumin-creatinine ratio > or =30 mg/g; adjustment was performed with multivariable logistic regression. RESULTS: Fully 39.6% of people with diagnosed and 41.7% with undiagnosed diabetes had CKD; 17.7% with prediabetes and 10.6% without diabetes had CKD. Age-, gender-, and race/ethnicity-adjusted prevalence of CKD was 32.9, 24.2, 17.1, and 11.8%, for diagnosed, undiagnosed, pre-, and no diabetes, respectively. Among those with CKD, 39.1% had undiagnosed or prediabetes. CONCLUSIONS: CKD prevalence is high among people with undiagnosed diabetes and prediabetes. These individuals might benefit from interventions aimed at preventing development and/or progression of both CKD and diabetes. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/20338960/Prevalence_of_chronic_kidney_disease_in_US_adults_with_undiagnosed_diabetes_or_prediabetes_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=20338960 DB - PRIME DP - Unbound Medicine ER -