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308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized study.
Br J Dermatol. 2010 Jul; 163(1):188-92.BJ

Abstract

BACKGROUND

The 308-nm excimer laser and 308-nm excimer lamp have both been shown to be effective in treating vitiligo but a direct comparison has never been performed.

OBJECTIVES

To test the equivalence of these two devices for treating nonsegmental vitiligo.

PATIENTS AND METHODS

A randomized monocentric study was undertaken. One lesion was treated with the 308-nm excimer laser and its counterpart with the 308-nm excimer lamp. Lesions were treated twice weekly with the same dose on both sides for a total of 24 sessions. The evaluation was done by two independent physicians blinded to the treatment on direct light and ultraviolet light photos.

RESULTS

Twenty patients were included: 17 completed the study and 104 lesions were treated. The two treatments showed similar results in terms of efficacy for a repigmentation of at least 50% (P = 0.006). The lamp induced more erythema than the laser.

CONCLUSIONS

The 308-nm excimer lamp and laser showed a similar efficacy in treating vitiligo. For the same fluence, the lamp induced more erythema suggesting photobiological differences between the two devices.

Authors+Show Affiliations

Department of Dermatology, University Hospital of Nice, Rte de St-Antoine de Ginestiere, 06200 Nice, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20346025

Citation

Le Duff, F, et al. "308-nm Excimer Lamp Vs. 308-nm Excimer Laser for Treating Vitiligo: a Randomized Study." The British Journal of Dermatology, vol. 163, no. 1, 2010, pp. 188-92.
Le Duff F, Fontas E, Giacchero D, et al. 308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized study. Br J Dermatol. 2010;163(1):188-92.
Le Duff, F., Fontas, E., Giacchero, D., Sillard, L., Lacour, J. P., Ortonne, J. P., & Passeron, T. (2010). 308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized study. The British Journal of Dermatology, 163(1), 188-92. https://doi.org/10.1111/j.1365-2133.2010.09778.x
Le Duff F, et al. 308-nm Excimer Lamp Vs. 308-nm Excimer Laser for Treating Vitiligo: a Randomized Study. Br J Dermatol. 2010;163(1):188-92. PubMed PMID: 20346025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized study. AU - Le Duff,F, AU - Fontas,E, AU - Giacchero,D, AU - Sillard,L, AU - Lacour,J-P, AU - Ortonne,J-P, AU - Passeron,T, Y1 - 2010/03/23/ PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/12/24/medline SP - 188 EP - 92 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 163 IS - 1 N2 - BACKGROUND: The 308-nm excimer laser and 308-nm excimer lamp have both been shown to be effective in treating vitiligo but a direct comparison has never been performed. OBJECTIVES: To test the equivalence of these two devices for treating nonsegmental vitiligo. PATIENTS AND METHODS: A randomized monocentric study was undertaken. One lesion was treated with the 308-nm excimer laser and its counterpart with the 308-nm excimer lamp. Lesions were treated twice weekly with the same dose on both sides for a total of 24 sessions. The evaluation was done by two independent physicians blinded to the treatment on direct light and ultraviolet light photos. RESULTS: Twenty patients were included: 17 completed the study and 104 lesions were treated. The two treatments showed similar results in terms of efficacy for a repigmentation of at least 50% (P = 0.006). The lamp induced more erythema than the laser. CONCLUSIONS: The 308-nm excimer lamp and laser showed a similar efficacy in treating vitiligo. For the same fluence, the lamp induced more erythema suggesting photobiological differences between the two devices. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/20346025/308_nm_excimer_lamp_vs__308_nm_excimer_laser_for_treating_vitiligo:_a_randomized_study_ L2 - https://doi.org/10.1111/j.1365-2133.2010.09778.x DB - PRIME DP - Unbound Medicine ER -