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Type 1 interferon signature in the scalp lesions of alopecia areata.
Br J Dermatol. 2010 Jul; 163(1):57-62.BJ

Abstract

BACKGROUND

Autoimmune attack of the bulbar region of anagen phase hair follicles by CD8+ T cells and Th1 cytokines has been proposed to result in hair loss in alopecia areata (AA). The initiating stimuli are unknown. As interferon-alpha therapy may trigger AA, we propose that type 1 interferons are involved in the induction of disease.

OBJECTIVES

To compare lesional scalp from patients with AA with scalp lesions of cutaneous diseases associated with local type 1 interferon-related protein expression.

METHODS

Lesional scalp of patients with AA, discoid lupus erythematosus, lichen planopilaris and androgenetic alopecia was examined by immunohistochemistry for expression of the type 1 interferon-inducible myxovirus protein A (MxA), the chemokine receptor CXCR3, and the cytotoxic proteins granzyme B (GrB) and T-cell intracytoplasmic antigen 1 (TiA-1).

RESULTS

MxA was expressed in the intradermal and subcutaneous compartments of the hair follicle including sebaceous glands in inflammatory AA similar to lesions of cicatricial alopecia (discoid lupus erythematosus, lichen planopilaris) but not in the epidermal compartment of AA, and not at all in noninflammatory AA or androgenetic alopecia. The location of CXCR3-expressing cells correlated with MxA expression. The inflammatory cells around the hair follicle in AA included a lower number of GrB+ and TiA-1+ cells compared with cicatricial alopecia and demonstrated predominant TiA-1+ expression.

CONCLUSIONS

We demonstrate the expression of type 1 interferon-related proteins in the inflammatory lesions of AA. The distribution pattern of the interferon signature and cytotoxicity-associated proteins in AA differs from cicatricial alopecia.

Authors+Show Affiliations

Department of Dermatology & Skin Science and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20346028

Citation

Ghoreishi, M, et al. "Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata." The British Journal of Dermatology, vol. 163, no. 1, 2010, pp. 57-62.
Ghoreishi M, Martinka M, Dutz JP. Type 1 interferon signature in the scalp lesions of alopecia areata. Br J Dermatol. 2010;163(1):57-62.
Ghoreishi, M., Martinka, M., & Dutz, J. P. (2010). Type 1 interferon signature in the scalp lesions of alopecia areata. The British Journal of Dermatology, 163(1), 57-62. https://doi.org/10.1111/j.1365-2133.2010.09775.x
Ghoreishi M, Martinka M, Dutz JP. Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata. Br J Dermatol. 2010;163(1):57-62. PubMed PMID: 20346028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 1 interferon signature in the scalp lesions of alopecia areata. AU - Ghoreishi,M, AU - Martinka,M, AU - Dutz,J P, Y1 - 2010/03/19/ PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/12/24/medline SP - 57 EP - 62 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 163 IS - 1 N2 - BACKGROUND: Autoimmune attack of the bulbar region of anagen phase hair follicles by CD8+ T cells and Th1 cytokines has been proposed to result in hair loss in alopecia areata (AA). The initiating stimuli are unknown. As interferon-alpha therapy may trigger AA, we propose that type 1 interferons are involved in the induction of disease. OBJECTIVES: To compare lesional scalp from patients with AA with scalp lesions of cutaneous diseases associated with local type 1 interferon-related protein expression. METHODS: Lesional scalp of patients with AA, discoid lupus erythematosus, lichen planopilaris and androgenetic alopecia was examined by immunohistochemistry for expression of the type 1 interferon-inducible myxovirus protein A (MxA), the chemokine receptor CXCR3, and the cytotoxic proteins granzyme B (GrB) and T-cell intracytoplasmic antigen 1 (TiA-1). RESULTS: MxA was expressed in the intradermal and subcutaneous compartments of the hair follicle including sebaceous glands in inflammatory AA similar to lesions of cicatricial alopecia (discoid lupus erythematosus, lichen planopilaris) but not in the epidermal compartment of AA, and not at all in noninflammatory AA or androgenetic alopecia. The location of CXCR3-expressing cells correlated with MxA expression. The inflammatory cells around the hair follicle in AA included a lower number of GrB+ and TiA-1+ cells compared with cicatricial alopecia and demonstrated predominant TiA-1+ expression. CONCLUSIONS: We demonstrate the expression of type 1 interferon-related proteins in the inflammatory lesions of AA. The distribution pattern of the interferon signature and cytotoxicity-associated proteins in AA differs from cicatricial alopecia. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/20346028/Type_1_interferon_signature_in_the_scalp_lesions_of_alopecia_areata_ L2 - https://doi.org/10.1111/j.1365-2133.2010.09775.x DB - PRIME DP - Unbound Medicine ER -